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Breakdown of the nuclear lamina
Stable Identifier
R-HSA-352238
Type
Pathway
Species
Homo sapiens
Compartment
nuclear envelope
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Apoptotic execution phase (Homo sapiens)
Apoptotic cleavage of cellular proteins (Homo sapiens)
Breakdown of the nuclear lamina (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
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|
PNG
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Activated caspases cleave nuclear lamins causing the irreversible breakdown of the nuclear lamina.
Literature References
PubMed ID
Title
Journal
Year
12655297
Many cuts to ruin: a comprehensive update of caspase substrates
Janicke, RU
,
Schulze-Osthoff, K
,
Fischer, U
Cell Death Differ
2003
Participants
Events
Caspase-6 translocates to the nucleus
(Homo sapiens)
Caspase-mediated cleavage of Lamin A
(Homo sapiens)
Caspase-mediated cleavage of Lamin B1
(Homo sapiens)
Participates
as an event of
Apoptotic cleavage of cellular proteins (Homo sapiens)
Orthologous Events
Breakdown of the nuclear lamina (Bos taurus)
Breakdown of the nuclear lamina (Canis familiaris)
Breakdown of the nuclear lamina (Danio rerio)
Breakdown of the nuclear lamina (Gallus gallus)
Breakdown of the nuclear lamina (Mus musculus)
Breakdown of the nuclear lamina (Rattus norvegicus)
Breakdown of the nuclear lamina (Sus scrofa)
Breakdown of the nuclear lamina (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000407
Authored
Schulze-Osthoff, K (2008-05-18)
Reviewed
Ranganathan, S (2008-06-11)
Created
Matthews, L (2008-06-02)
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