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LMNB1(232-586) [nuclear envelope]
Stable Identifier
R-HSA-352248
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nuclear envelope
Synonyms
Lamin B1 fragment (232-586)
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Apoptotic execution phase (Homo sapiens)
Apoptotic cleavage of cellular proteins (Homo sapiens)
Breakdown of the nuclear lamina (Homo sapiens)
Caspase-mediated cleavage of Lamin B1 (Homo sapiens)
LMNB1(232-586) [nuclear envelope] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20700 LMNB1
Gene Names
LMNB1, LMN2, LMNB
Chain
initiator methionine:, chain:2-583, propeptide:584-586
Reference Genes
BioGPS Gene:4001 LMNB1
COSMIC (genes):LMNB1 LMNB1
CTD Gene:4001 LMNB1
dbSNP Gene:4001 LMNB1
ENSEMBL:ENSG00000113368 LMNB1
ENSEMBL_homo_sapiens_GENE:ENSG00000113368.12 LMNB1
HGNC:6637 LMNB1
KEGG Gene (Homo sapiens):4001 LMNB1
Monarch:4001 LMNB1
NCBI Gene:4001 LMNB1
OMIM:150340 LMNB1
UCSC:P20700 LMNB1
Reference Transcript
RefSeq:NM_005573.3 LMNB1
Other Identifiers
11732533_a_at
11744888_a_at
11744889_a_at
11750441_a_at
11750442_s_at
16988703
203276_PM_at
203276_at
2827186
2827187
2827188
2827189
2827192
2827193
2827195
2827196
2827199
2827202
2827203
2827204
2827205
2827207
2827208
2827209
2827210
37985_at
4001
8107706
A_14_P108109
A_23_P258493
GO:0003677
GO:0003690
GO:0005198
GO:0005200
GO:0005515
GO:0005634
GO:0005635
GO:0005637
GO:0005638
GO:0005652
GO:0005654
GO:0005856
GO:0005882
GO:0006325
GO:0006998
GO:0007010
GO:0007097
GO:0016020
GO:0016363
GO:0031507
GO:0031965
GO:0034399
GO:0043226
GO:0043274
GO:0051664
GO:0061024
GO:0090435
GO:1990837
HMNXSV003035906
M34458_rna1_s_at
PH_hs_0004988
PH_hs_0040083
TC05000604.hg
g5031876_3p_at
g5031876_3p_x_at
Participates
as an output of
Caspase-mediated cleavage of Lamin B1 (Homo sapiens)
Other forms of this molecule
LMNB1 [nucleoplasm]
LMNB1(1-231) [nuclear envelope]
LMNB1 [cytosol]
p-S395, S405-LMNB1 [nucleoplasm]
p-S23, S395, S405-LMNB1 [nucleoplasm]
LMNB1(2-586) [nuclear envelope]
p-S23,S393-LMNB1 [nucleoplasm]
Inferred To
ifa-1 [nuclear envelope]
(Caenorhabditis elegans)
ifp-1 [nuclear envelope]
(Caenorhabditis elegans)
Lmnb1 [nuclear envelope]
(Mus musculus)
Lmnb1 [nuclear envelope]
(Rattus norvegicus)
ifd-2 [nuclear envelope]
(Caenorhabditis elegans)
yuri [nuclear envelope]
(Drosophila melanogaster)
LamC [nuclear envelope]
(Drosophila melanogaster)
ifd-1 [nuclear envelope]
(Caenorhabditis elegans)
Homologues of LMNB1(232-586) [nuclear envelope]
(Caenorhabditis elegans)
Homologues of LMNB1(232-586) [nuclear envelope]
(Drosophila melanogaster)
Lam [nuclear envelope]
(Drosophila melanogaster)
ifc-1 [nuclear envelope]
(Caenorhabditis elegans)
ifc-2 [nuclear envelope]
(Caenorhabditis elegans)
ifb-2 [nuclear envelope]
(Caenorhabditis elegans)
LMNB1 [nuclear envelope]
(Bos taurus)
LMNB1 [nuclear envelope]
(Canis familiaris)
LMNB1 [nuclear envelope]
(Sus scrofa)
ifb-1 [nuclear envelope]
(Caenorhabditis elegans)
LMNB1(232-586) [nuclear envelope]
(Gallus gallus)
ifa-3 [nuclear envelope]
(Caenorhabditis elegans)
lmnb1 [nuclear envelope]
(Danio rerio)
lmnb1 [nuclear envelope]
(Xenopus tropicalis)
ifa-4 [nuclear envelope]
(Caenorhabditis elegans)
lmn-1 [nuclear envelope]
(Caenorhabditis elegans)
mua-6 [nuclear envelope]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_005564.1
OpenTargets
ENSG00000113368
HPA
ENSG00000113368-LMNB1
GeneCards
P20700
Ensembl
ENSP00000261366
,
ENST00000261366
,
ENSG00000113368
PRO
P20700
Pharos - Targets
P20700
Orphanet
16365
PDB
3UMN
,
3TYY
,
7DTG
,
5BNW
,
3JT0
,
5VVX
,
2KPW
Interactors (23)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P02545 LMNA
3
LMNA(1-646) [nuclear envelope]
(R-HSA-535479)
LMNA(1-567)-RAF1(279-648) fusion [cytosol]
(R-HSA-6802399)
LMNA(1-567)-p-RAF1(279-648) fusion [cytosol]
(R-HSA-6802537)
0.933
23
UniProt:Q03252 LMNB2
0.85
8
UniProt:P52294 KPNA1
2
KPNA1 [cytosol]
(R-HSA-180612)
KPNA1 [nucleoplasm]
(R-HSA-188865)
0.742
5
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.706
21
UniProt:P02545-1 LMNA
7
p-S22, S392-LMNA-1 [nucleoplasm]
(R-HSA-8868349)
p-S22, S395-LMNA-1 [nucleoplasm]
(R-HSA-5229021)
p-S395-LMNA-1 [nucleoplasm]
(R-HSA-5228743)
LMNA-1 [cytosol]
(R-HSA-2995371)
LMNA(231-664) [nuclear envelope]
(R-HSA-352249)
LMNA(1-230) [nuclear envelope]
(R-HSA-352253)
Lamin A [nucleoplasm]
(R-HSA-264866)
0.677
5
UniProt:Q9GZQ8 MAP1LC3B
3
MAP1LC3B [autophagosome membrane]
(R-HSA-5683641)
MAP1LC3B(2-121) [cytosol]
(R-HSA-5682674)
MAP1LC3B [cytosol]
(R-HSA-5205651)
0.675
14
UniProt:O60684 KPNA6
2
KPNA6 [nucleoplasm]
(R-HSA-9734665)
KPNA6 [cytosol]
(R-HSA-9734672)
0.666
4
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.623
4
UniProt:P02545-2 LMNA
5
LMNA-2 [nuclear envelope]
(R-HSA-912378)
p-S22, S395-LMNA-2 [nucleoplasm]
(R-HSA-5229019)
p-S395-LMNA-2 [nucleoplasm]
(R-HSA-5228740)
Lamin C [nucleoplasm]
(R-HSA-264872)
LMNA-2 [cytosol]
(R-HSA-2995387)
0.601
19
UniProt:O95295 SNAPIN
2
SNAPIN [Golgi membrane]
(R-HSA-434344)
SNAPIN [cytoplasmic vesicle membrane]
(R-HSA-434204)
0.556
3
UniProt:Q9NPF5 DMAP1
1
DMAP1 [nucleoplasm]
(R-HSA-212166)
0.556
3
UniProt:A6NC98 CC88B
0.556
3
UniProt:Q9H3R5 CENPH
2
CENPH [nucleoplasm]
(R-HSA-606314)
CENPH [cytosol]
(R-HSA-375294)
0.556
3
UniProt:Q96KQ4 PPP1R13B
1
PPP1R13B [nucleoplasm]
(R-HSA-6799775)
0.556
3
UniProt:O15131 KPNA5
2
KPNA5 [nucleoplasm]
(R-HSA-1176068)
KPNA5 [cytosol]
(R-HSA-1176062)
0.556
3
UniProt:Q7KZS0 Q7KZS0
0.556
3
UniProt:Q8WWB5 PIHD2
0.556
3
UniProt:Q8TC57 M1AP
0.556
3
UniProt:Q9Y6X4 FAM169A
1
FAM169A [cytosol]
(R-HSA-9715125)
0.556
3
UniProt:Q05BL1 Q05BL1
0.556
3
UniProt:Q05322 VP24
0.499
6
UniProt:P36956-PRO_0000314029 SREBF1
0.489
2
UniProt:P06748 NPM1
11
monoSUMO1-K263-NPM1 [nucleoplasm]
(R-HSA-4086039)
polySUMO2,3-K263-NPM1 [nucleoplasm]
(R-HSA-4086056)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm]
(R-HSA-9725010)
NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730703)
NPM1(1-117)-ALK(1068-1620) fusion [cytosol]
(R-HSA-9730697)
NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699861)
NPM1(1-117)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9699834)
NPM1 [granular component]
(R-HSA-9017702)
NPM1 [nucleoplasm]
(R-HSA-606320)
NPM1 [cytosol]
(R-HSA-3008211)
p-S4-NPM1 [cytosol]
(R-HSA-6801679)
0.483
2
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