Translocation of PTK2 to Focal complexes

Stable Identifier
R-HSA-354066
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Translocation of PTK2 to Focal complexes
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As integrins do not have an intrinsic catalytic activity, the signals initiated by the ECM-integrin interactions are transduced into cells through the integrin bound protein-tyrosine kinases. PTK2 (protein-tyrosine kinase 2, also known as Focal adhesion kinase 1; FADK1, FAK) is one of the protein tyrosine kinases that plays a prominent role in integrin signaling. PTK2 has been implicated in controlling cell motility and transmitting a cell survival signal from ECM.

PTK2 is recruited to sites of integrin clustering by directly binding to integrin associated c-Src.
Literature References
PubMed ID Title Journal Year
11476890 Biochemical signals and biological responses elicited by the focal adhesion kinase

Schaller, MD

Biochim Biophys Acta 2001
16919435 Integrin-regulated FAK-Src signaling in normal and cancer cells

Mitra, SK, Schlaepfer, DD

Curr Opin Cell Biol 2006
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Orthologous Events
Translocation of PTK2 to Focal complexes (Bos taurus)
Translocation of PTK2 to Focal complexes (Caenorhabditis elegans)
Translocation of PTK2 to Focal complexes (Canis familiaris)
Translocation of PTK2 to Focal complexes (Gallus gallus)
Translocation of PTK2 to Focal complexes (Mus musculus)
Translocation of PTK2 to Focal complexes (Rattus norvegicus)
Authored
Garapati, P V  (2008-06-16)
Reviewed
Shattil, SJ  (2008-09-16)
Created
Garapati, P V  (2008-06-16)
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