Reactome | p-Y397-PTK2 [cytosol]

p-Y397-PTK2 [cytosol]

Stable Identifier

R-HSA-354068

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-Y397-FAK1, auto phosphorylated FAK 1

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Locations in the PathwayBrowser for interactor UniProt:Q9H3S7 PTPN23

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External Reference Information

External Reference

UniProt:Q05397 PTK2

Gene Names

PTK2, FAK, FAK1

Chain

initiator methionine:, chain:2-1052

Reference Genes

BioGPS Gene:5747 PTK2

COSMIC (genes):PTK2 PTK2

CTD Gene:5747 PTK2

dbSNP Gene:5747 PTK2

ENSEMBL:ENSG00000169398 PTK2

HGNC:9611 PTK2

KEGG:hsa:5747 PTK2

Monarch:5747 PTK2

NCBI Gene:5747 PTK2

OMIM:600758 PTK2

UCSC:Q05397 PTK2

Reference Transcript

Other Identifiers

11716373_a_at

11716374_s_at

11747793_a_at

17081737

207821_PM_s_at

207821_s_at

208820_PM_at

208820_at

241387_PM_at

241387_at

241453_PM_at

241453_at

312_s_at

3156306

3156308

3156309

3156310

3156313

3156315

3156316

3156317

3156318

3156322

3156324

3156328

3156329

3156335

3156336

3156337

3156338

3156339

3156341

3156342

3156345

3156346

3156347

3156348

3156351

3156354

3156355

3156356

3156357

3156358

3156360

3156361

3156362

3156364

3156365

3156366

3156367

3156368

3156369

3156371

3156372

3156373

3156375

3156377

3156378

3156379

3156383

3156387

3156388

3156392

3156393

3156396

3156397

3156400

3156402

3156403

3156404

3156410

3156417

3156418

3156419

3156420

3156424

3156425

3156426

3156432

3156433

3156434

3156435

3156437

3156446

3156456

3156457

3156463

3156464

3156465

36117_at

52392_s_at

5747

71472_at

72349_at

73996_at

8153223

A_23_P22096

A_23_P324679

A_23_P72050

A_33_P3416707

GE581949

GE79453

GE85906

GO:0001525

GO:0001725

GO:0001890

GO:0001932

GO:0001934

GO:0002376

GO:0003007

GO:0003779

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0004725

GO:0005178

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0005925

GO:0005938

GO:0006468

GO:0007163

GO:0007172

GO:0007173

GO:0007179

GO:0007229

GO:0007411

GO:0008092

GO:0008284

GO:0008360

GO:0008432

GO:0010594

GO:0010632

GO:0010634

GO:0010718

GO:0010759

GO:0010763

GO:0016301

GO:0016477

GO:0016740

GO:0016787

GO:0018108

GO:0019901

GO:0019903

GO:0022408

GO:0030010

GO:0030054

GO:0030155

GO:0030335

GO:0033628

GO:0035995

GO:0036064

GO:0038007

GO:0038096

GO:0042127

GO:0042169

GO:0042995

GO:0043066

GO:0043087

GO:0043197

GO:0043226

GO:0043231

GO:0045667

GO:0045860

GO:0046777

GO:0048010

GO:0048013

GO:0048471

GO:0048856

GO:0048870

GO:0051128

GO:0051239

GO:0051493

GO:0051893

GO:0051897

GO:0060396

GO:0065003

GO:0065008

GO:0070161

GO:0090303

GO:0098772

GO:0120041

GO:0140096

GO:0140677

GO:1900024

GO:1902531

GO:2000060

GO:2000811

HMNXSV003030583

Hs.126421.0.A1_3p_at

Hs.126421.0.A1_3p_x_at

Hs.224812.0.A1_3p_at

Hs.740.1.S2_3p_at

Hs.740.1.S2_3p_x_at

ILMN_1676305

ILMN_1714364

PH_hs_0025321

g5032000_3p_a_at

Participates

as a component of

as an output of

Phosphorylation of PTK2 (FAK) on tyrosine-397 in response to turbulent blood flow (Homo sapiens)

This entity regulates

Positively

PTK2 (FAK) and Gq/11 enhance the degradation of NFKBIA (IkBalpha), phosphorylation of RELA (p65) on serine-536, and translocation of p-S536-RELA:NFKB1 (p65:p50) to the nucleus (Homo sapiens)

Other forms of this molecule

p-6Y-PTK2 [cytosol]

PTK2 [cytosol]

PTK2(1-772) [cytosol]

PTK2(773-1052) [cytosol]

p-5Y-PTK2 [cytosol]

p-5Y,S732-PTK2 [cytosol]

p-6Y,S732-PTK2 [cytosol]

pY-PTK2 [cytosol]

p-Y194,Y397-PTK2 [cytosol]

p-Y194,Y397,Y576,Y577-PTK2 [cytosol]

Inferred To

Ghost homologue of p-Y397-PTK2 [cytosol] (Danio rerio)

Ghost homologue of p-Y397-PTK2 [cytosol] (Drosophila melanogaster)

Ghost homologue of p-Y397-PTK2 [cytosol] (Sus scrofa)

Ghost homologue of p-Y397-PTK2 [cytosol] (Xenopus tropicalis)

phospho-PTK2 [cytosol] (Canis familiaris)

phospho-p-Y397-PTK2 [cytosol] (Bos taurus)

phospho-p-Y397-PTK2 [cytosol] (Caenorhabditis elegans)

phospho-p-Y397-PTK2 [cytosol] (Gallus gallus)

phospho-p-Y397-PTK2 [cytosol] (Mus musculus)

phospho-p-Y397-PTK2 [cytosol] (Rattus norvegicus)

Modified Residues

Name

O4'-phospho-L-tyrosine at 397

Coordinate

397

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001186578.1, XP_016869162.1, NP_722560.1

ZINC - World Drugs

FAK1_HUMAN

Guide to Pharmacology - Targets

2180

OpenTargets

ENSG00000169398

ENSEMBL

ENSP00000341189, ENST00000340930, ENSP00000429911, ENST00000395218, ENSP00000378644, ENSP00000429474, ENST00000522684, ENST00000521059

ZINC - FDA approved

FAK1_HUMAN

ZINC - Substances

FAK1_HUMAN

ZINC - Biogenic

FAK1_HUMAN

ZINC target

Q05397

PRO

Q05397

GlyGen

Q05397

PDB

4K9Y, 6PW8, 4GU9, 1K04, 4GU6, 1OW7, 1OW6, 2ETM, 3B71, 7PI4, 6LES, 4NY0, 6YR9, 3S9O, 1K05, 7W8I, 6YOJ, 7W8B, 1OW8, 6YT6, 4KAO, 6I8Z, 7W7Z, 7W9U, 3BZ3, 4I4F, 4KAB, 6YVY, 4I4E, 3PXK, 4EBV, 4EBW, 6YQ1, 4K8A, 6YVS, 6YXV, 1MP8, 2IJM, 4Q9S

ZINC - Investigational

FAK1_HUMAN

ZINC - Metabolites

FAK1_HUMAN

HPA

ENSG00000169398-PTK2

Pharos - Targets

Q05397

ZINC - Predictions - Purchasable

FAK1_HUMAN

HMDB Protein

HMDBP01281

Interactors (32)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49023 PXN	4	p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [plasma membrane] (R-HSA-180493) PXN [cytosol] (R-HSA-210014) p-Y31,Y118-PXN [cytosol] (R-HSA-5218693)	0.942	19
UniProt:P12931 SRC	6	MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-SRC [plasma membrane] (R-HSA-8876922) p-Y419-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690)	0.924	9
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.751	13
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.745	7
UniProt:P05480 Src	13	SRC-2 [cytosol] (R-MMU-191648) phospho-MyrG-p-Y419-SRC [plasma membrane] (R-MMU-1810408) SRC-1 [plasma membrane] (R-MMU-65043) phospho-MyrG,p-Y530-SRC [plasma membrane] (R-MMU-377598) phospho-p-Y419-SRC [cytosol] (R-MMU-377592) Src [cytosol] (R-MMU-418782) phospho-p-Y419-SRC-1 [plasma membrane] (R-MMU-112331) MyrG-SRC [plasma membrane] (R-MMU-8876922) phospho-p-Y419-SRC [cytosol] (R-MMU-8964276) SRC [cytosol] (R-MMU-9628701) MyrG-p-Y424-Src [plasma membrane] (R-MMU-9011258) Activated Src [nucleoplasm] (R-MMU-8937700) p-Y416-Src [cytosol] (R-MMU-8964306)	0.683	5
UniProt:O43294 TGFI1			0.678	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.659	4
UniProt:O60711 LPXN			0.659	4
UniProt:Q9H3S7 PTPN23	1	PTPN23 [nucleoplasm] (R-HSA-9008924)	0.639	4
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.635	3
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.632	3
UniProt:Q96SB4 SRPK1	2	SRPK1 [nucleoplasm] (R-HSA-9821984) SRPK1 [cytosol] (R-HSA-9729349)	0.59	2
UniProt:P56945 BCAR1	4	BCAR1 [cytosol] (R-HSA-201625) p-Y165,Y664-BCAR1 [cytosol] (R-HSA-8848723) p-Y12-BCAR1 [cytosol] (R-HSA-5218739) p-Y-BCAR1 [cytosol] (R-HSA-372645)	0.589	2
UniProt:P07948 LYN	7	LYN [cytosol] (R-HSA-354251) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875) p-Y397-LYN [plasma membrane] (R-HSA-2454229) p-Y397-LYN [cytosol] (R-HSA-8942608) LYN [plasma membrane] (R-HSA-197943) MyrG2-PalmC3-LYN [endocytic vesicle membrane] (R-HSA-9705728) MyrG2-PalmC3-LYN [lysosomal membrane] (R-HSA-9707903)	0.573	2
UniProt:Q9NP31 SH2D2A	1	SH2D2A [cytosol] (R-HSA-4420125)	0.57	3
UniProt:Q14451 GRB7	1	GRB7 [cytosol] (R-HSA-204819)	0.57	3
UniProt:P29350-3 PTPN6			0.57	3
UniProt:Q68CZ2 TNS3	1	TNS3 [cytosol] (R-HSA-8875524)	0.556	3
UniProt:P06241 FYN	6	FYN [cytosol] (R-HSA-200917) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y531-FYN [cytosol] (R-HSA-391819) p-S21,Y420-FYN [cytosol] (R-HSA-5218745)	0.547	3
UniProt:Q824H6 Q824H6			0.543	3
UniProt:P78396 CCNA1	3	PolyUb-CCNA1 [nucleoplasm] (R-HSA-6783068) CCNA1 [cytosol] (R-HSA-157446) CCNA1 [nucleoplasm] (R-HSA-68891)	0.536	2
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.536	2
UniProt:P42224 STAT1	8	STAT1 [cytosol] (R-HSA-629622) p-Y701-STAT1 [cytosol] (R-HSA-3132766) p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624) p-Y701-STAT1 [cytosol] (R-HSA-8951202) p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905) p-Y701,S727-STAT1 [cytosol] (R-HSA-9850842) p-STAT1 [cytosol] (R-HSA-8950418) p-STAT1 [nucleoplasm] (R-HSA-8987140)	0.536	3
UniProt:P05120 SERPINB2	2	SERPINB2 [plasma membrane] (R-HSA-159004) SERPINB2 [extracellular region] (R-HSA-158997)	0.527	2
UniProt:P16144 ITGB4	1	ITGB4 [plasma membrane] (R-HSA-215947)	0.524	7
UniProt:Q62219 TGFI1			0.524	3
UniProt:P08631-2 HCK			0.508	2
UniProt:P29317 EPHA2	2	p-Y588,Y594-EPHA2 [plasma membrane] (R-HSA-3928380) EPHA2 [plasma membrane] (R-HSA-211422)	0.488	3
UniProt:Q8TEW6 DOK4	1	DOK4 [cytosol] (R-HSA-8847701)	0.488	2
UniProt:O60880 SH2D1A	1	SH2D1A [cytosol] (R-HSA-5685108)	0.488	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	10
UniProt:Q80ZW7 Q80ZW7			0.463	2

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