Autophosphorylation of PTK2 at Y397

Stable Identifier
R-HSA-354073
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Autophosphorylation of PTK2 at Y397
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The co-localization of PTK2/FAK with integrins in focal adhesions and the actin cytoskeleton is essential for the activation and phosphorylation of PTK2/FAK.
PTK2/FAK has six tyrosine phosphorylation sites and tyrosine 397 is the main auto-phosphorylation site present upstream of the kinase domain.
Literature References
PubMed ID Title Journal Year
11476890 Biochemical signals and biological responses elicited by the focal adhesion kinase

Schaller, MD

Biochim Biophys Acta 2001
16919435 Integrin-regulated FAK-Src signaling in normal and cancer cells

Mitra, SK, Schlaepfer, DD

Curr Opin Cell Biol 2006
Participants
Input
Output
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as an event of
Catalyst Activity

protein tyrosine kinase activity of Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane]

Physical Entity
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
Autophosphorylation of PTK2 at Y397 (Bos taurus)
Autophosphorylation of PTK2 at Y397 (Caenorhabditis elegans)
Autophosphorylation of PTK2 at Y397 (Canis familiaris)
Autophosphorylation of PTK2 at Y397 (Gallus gallus)
Autophosphorylation of PTK2 at Y397 (Mus musculus)
Autophosphorylation of PTK2 at Y397 (Rattus norvegicus)
Autophosphorylation of PTK2 at Y397 (Sus scrofa)
Authored
Garapati, P V  (2008-06-16)
Reviewed
Shattil, SJ  (2008-09-16)
Created
Garapati, P V  (2008-06-16)
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