Recruitment of GRB2 to p-PTK2

Stable Identifier
R-HSA-354087
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Recruitment of GRB2 to p-PTK2
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Phosphorylated tyrosine 925 in the FAT domain of PTK2/FAK creates a docking site for the SH2 domain of GRB2 and recruits the GRB2/SOS complex. PTK2 may use this mechanism to activate Ras and the MAP kinase pathway.
Literature References
Participants
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Output
Participates
as an event of
Orthologous Events
Recruitment of GRB2 to p-PTK2 (Bos taurus)
Recruitment of GRB2 to p-PTK2 (Caenorhabditis elegans)
Recruitment of GRB2 to p-PTK2 (Canis familiaris)
Recruitment of GRB2 to p-PTK2 (Gallus gallus)
Recruitment of GRB2 to p-PTK2 (Mus musculus)
Recruitment of GRB2 to p-PTK2 (Rattus norvegicus)
Recruitment of GRB2 to p-PTK2 (Sus scrofa)
Authored
Garapati, P V  (2008-06-16)
Reviewed
Shattil, SJ  (2008-09-16)
Created
Garapati, P V  (2008-06-16)
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