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ACTN1 [cytosol]
Stable Identifier
R-HSA-354096
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Alpha-actinin 1
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Cell junction organization (Homo sapiens)
Cell-extracellular matrix interactions (Homo sapiens)
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components (Homo sapiens)
PARVB interacts with Alpha-actinin (Homo sapiens)
ACTN1 [cytosol] (Homo sapiens)
PARVB:alpha actinin [cytosol] (Homo sapiens)
ACTN1 [cytosol] (Homo sapiens)
Nephrin family interactions (Homo sapiens)
Interaction of nephrin with adherens junction-associated proteins (Homo sapiens)
Nephrin dimer:adherins junction-associated proteins [plasma membrane] (Homo sapiens)
adherens junction-associated proteins [cytosol] (Homo sapiens)
Alpha-actinin [cytosol] (Homo sapiens)
ACTN1 [cytosol] (Homo sapiens)
adherens junction-associated proteins [cytosol] (Homo sapiens)
Alpha-actinin [cytosol] (Homo sapiens)
ACTN1 [cytosol] (Homo sapiens)
Extracellular matrix organization (Homo sapiens)
Non-integrin membrane-ECM interactions (Homo sapiens)
Syndecan interactions (Homo sapiens)
Syndecan-4 binds ACTN1 (Homo sapiens)
ACTN1 [cytosol] (Homo sapiens)
Syndecan-4:ACTN1 [plasma membrane] (Homo sapiens)
ACTN1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RHOBTB GTPase Cycle (Homo sapiens)
RHOBTB2 GTPase cycle (Homo sapiens)
RHOBTB2 binds interacting proteins at the endosome membrane (Homo sapiens)
RHOBTB2 interacting proteins [cytosol] (Homo sapiens)
ACTN1 [cytosol] (Homo sapiens)
RHOBTB2:GTP:RHOBTB2 interacting proteins [endosome membrane] (Homo sapiens)
RHOBTB2 interacting proteins [cytosol] (Homo sapiens)
ACTN1 [cytosol] (Homo sapiens)
RHOD GTPase cycle (Homo sapiens)
RHOD binds effectors at the plasma membrane (Homo sapiens)
RHOD plasma membrane effectors [cytosol] (Homo sapiens)
ACTN1 [cytosol] (Homo sapiens)
RHOD:GTP:RHOD plasma membrane effectors [plasma membrane] (Homo sapiens)
RHOD plasma membrane effectors [cytosol] (Homo sapiens)
ACTN1 [cytosol] (Homo sapiens)
RHOF GTPase cycle (Homo sapiens)
RHOF binds effectors at the plasma membrane (Homo sapiens)
RHOF effectors [cytosol] (Homo sapiens)
ACTN1 [cytosol] (Homo sapiens)
RHOF:GTP:RHOF effectors [plasma membrane] (Homo sapiens)
RHOF effectors [cytosol] (Homo sapiens)
ACTN1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P12814 ACTN1
Gene Names
ACTN1
Chain
chain:1-892
Reference Genes
BioGPS Gene:87 ACTN1
COSMIC (genes):ACTN1 ACTN1
CTD Gene:87 ACTN1
dbSNP Gene:87 ACTN1
ENSEMBL:ENSG00000072110 ACTN1
ENSEMBL_homo_sapiens_GENE:ENSG00000072110.16 ACTN1
HGNC:163 ACTN1
KEGG Gene (Homo sapiens):87 ACTN1
Monarch:87 ACTN1
NCBI Gene:87 ACTN1
OMIM:102575 ACTN1
UCSC:P12814 ACTN1
Reference Transcript
RefSeq:NM_001130004.1 ACTN1
RefSeq:NM_001130005.1 ACTN1
RefSeq:NM_001102.3 ACTN1
Other Identifiers
11728374_s_at
11728375_x_at
11743969_s_at
11743970_x_at
11751116_a_at
11751117_x_at
208636_PM_at
208636_at
208637_PM_x_at
208637_x_at
211160_PM_x_at
211160_x_at
3569815
3569816
3569817
3569818
3569819
3569820
3569821
3569822
3569823
3569825
3569827
3569830
3569832
3569834
3569835
3569836
3569840
3569841
3569842
3569846
3569847
3569849
3569850
3569859
3569860
3569862
3569864
3569866
3569869
3569871
3569873
3569908
3569909
3569910
39329_at
39330_s_at
7979824
87
A_23_P105957
A_24_P107695
GE61093
GO:0001725
GO:0001726
GO:0003723
GO:0003725
GO:0003779
GO:0005178
GO:0005198
GO:0005509
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005829
GO:0005856
GO:0005884
GO:0005886
GO:0005903
GO:0005911
GO:0005916
GO:0005925
GO:0006351
GO:0006355
GO:0007010
GO:0007015
GO:0007155
GO:0008092
GO:0012501
GO:0015629
GO:0016020
GO:0017166
GO:0030017
GO:0030018
GO:0030036
GO:0030054
GO:0030154
GO:0030220
GO:0030374
GO:0030864
GO:0031093
GO:0031143
GO:0031410
GO:0034330
GO:0036344
GO:0042803
GO:0042981
GO:0042995
GO:0043226
GO:0044325
GO:0045893
GO:0046872
GO:0048041
GO:0048856
GO:0051015
GO:0051017
GO:0051639
GO:0055001
GO:0070062
GO:0070161
GO:0098978
GO:0099173
GO:0099186
GO:0140110
HMNXSV003005404
Hs.119000.1.S2_3p_at
ILMN_2232177
M95178_at
PH_hs_0027789
PH_hs_0031573
TC14001255.hg
TC14002059.hg
g13097755_3p_a_at
Participates
as a candidate of
RHOBTB2 interacting proteins [cytosol] (Homo sapiens)
RHOD plasma membrane effectors [cytosol] (Homo sapiens)
RHOF effectors [cytosol] (Homo sapiens)
as a component of
Syndecan-4:ACTN1 [plasma membrane] (Homo sapiens)
PARVB:alpha actinin [cytosol] (Homo sapiens)
as an input of
Syndecan-4 binds ACTN1 (Homo sapiens)
PARVB interacts with Alpha-actinin (Homo sapiens)
as a member of
Alpha-actinin [cytosol] (Homo sapiens)
Other forms of this molecule
ACTN1 [platelet alpha granule lumen]
ACTN1 [extracellular region]
Inferred To
atn-1 [cytosol]
(Caenorhabditis elegans)
ain1 [cytosol]
(Schizosaccharomyces pombe)
abpD [cytosol]
(Dictyostelium discoideum)
ACTN1 [cytosol]
(Bos taurus)
ACTN1 [cytosol]
(Canis familiaris)
ACTN1 [cytosol]
(Dictyostelium discoideum)
ACTN1 [cytosol]
(Drosophila melanogaster)
ACTN1 [cytosol]
(Gallus gallus)
ACTN1 [cytosol]
(Mus musculus)
ACTN1 [cytosol]
(Sus scrofa)
Homologues of ACTN1 [cytosol]
(Dictyostelium discoideum)
Homologues of ACTN1 [cytosol]
(Drosophila melanogaster)
Actn1 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_001123477.1
,
NP_001123476.1
,
NP_001093.1
OpenTargets
ENSG00000072110
GeneCards
P12814
HPA
ENSG00000072110-ACTN1
Ensembl
ENSG00000072110
,
ENSP00000193403
,
ENSP00000414272
,
ENSP00000377941
,
ENST00000538545
,
ENST00000438964
,
ENSP00000439828
,
ENST00000193403
,
ENST00000394419
PRO
P12814
Pharos - Targets
P12814
Orphanet
21974
PDB
2EYI
,
2EYN
,
2N8Z
,
2N8Y
Interactors (42)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NPC6 MYOZ2
0.805
11
UniProt:Q8IY33 MILK2
0.718
6
UniProt:Q7L775 EPMIP
0.718
6
UniProt:Q9NWQ9 CN119
0.666
4
UniProt:Q9NP98 MYOZ1
0.666
4
UniProt:P00973 OAS1
1
OAS1 [cytosol]
(R-HSA-947486)
0.666
4
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
19
UniProt:P27958-PRO_0000037577
0.611
7
UniProt:Q9Y223 GNE
9
GNE V572L [cytosol]
(R-HSA-4088323)
GNE M712T [cytosol]
(R-HSA-4088386)
GNE R263L [cytosol]
(R-HSA-4088402)
GNE R266W [cytosol]
(R-HSA-4088372)
GNE R266Q [cytosol]
(R-HSA-4088390)
GNE A631V [cytosol]
(R-HSA-4088376)
GNE M171V [cytosol]
(R-HSA-4088351)
GNE C303V [cytosol]
(R-HSA-4088366)
GNE [cytosol]
(R-HSA-3781927)
0.591
3
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.569
6
UniProt:Q8N3V7 SYNPO
0.564
2
UniProt:P05198 EIF2S1
2
p-S52-EIF2S1 [cytosol]
(R-HSA-381060)
EIF2S1 [cytosol]
(R-HSA-72510)
0.556
3
UniProt:B2R8Y4 B2R8Y4
0.556
3
UniProt:P63172 DYNLT1
3
DYNLT1 [secretory granule lumen]
(R-HSA-6801497)
DYNLT1 [extracellular region]
(R-HSA-6806509)
DYNLT1 [ficolin-1-rich granule lumen]
(R-HSA-6801487)
0.556
3
UniProt:P50479 PDLI4
0.556
3
UniProt:P35609 ACTN2
3
ACTN2 [cytosol]
(R-HSA-390562)
ACTN2 [platelet alpha granule lumen]
(R-HSA-349727)
ACTN2 [extracellular region]
(R-HSA-349725)
0.556
3
UniProt:Q6ZUT1 NKAP1
0.556
3
UniProt:Q92624 APBP2
0.556
3
UniProt:A0A0S2Z4Y0 A0A0S2Z4Y0
0.556
3
UniProt:Q9H987-2 SYNPO2L
0.556
3
UniProt:Q8TBB1 LNX1
1
LNX1 [cytosol]
(R-HSA-8851641)
0.556
3
UniProt:P10599 TXN
4
2xHC-TXN [nucleoplasm]
(R-HSA-9617733)
TXN [nucleoplasm]
(R-HSA-9617732)
2xHC-TXN [cytosol]
(R-HSA-73668)
TXN [cytosol]
(R-HSA-66000)
0.556
3
UniProt:O95257 GA45G
0.556
3
UniProt:Q8NA61 CBY2
0.556
3
UniProt:P00973-2 OAS1
0.556
3
UniProt:Q08043 ACTN3
1
ACTN3 [cytosol]
(R-HSA-390565)
0.556
3
UniProt:Q8NC69 KCTD6
1
KCTD6 [cytosol]
(R-HSA-8863321)
0.556
3
UniProt:O75604 USP2
2
USP2 [cytosol]
(R-HSA-5212661)
USP2 [nucleoplasm]
(R-HSA-5689946)
0.556
3
UniProt:P12814 ACTN1
3
ACTN1 [cytosol]
(R-HSA-354096)
ACTN1 [platelet alpha granule lumen]
(R-HSA-349724)
ACTN1 [extracellular region]
(R-HSA-349722)
0.553
2
UniProt:Q8VC66 ADIP
0.544
3
UniProt:P03372 ESR1
10
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.527
3
UniProt:Q92731 ESR2
5
PalmS-ESR2 [cytosol]
(R-HSA-9020979)
Me-PalmS-ESR2 [plasma membrane]
(R-HSA-9637787)
PalmS-ESR2 [plasma membrane]
(R-HSA-9021059)
ESR2 [nucleoplasm]
(R-HSA-446165)
ESR2 [cytosol]
(R-HSA-9020970)
0.527
2
UniProt:Q9NR12 PDLIM7
1
PDLIM7 [cytosol]
(R-HSA-8855085)
0.527
5
UniProt:P12931 SRC
6
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
SRC [cytosol]
(R-HSA-9628701)
p-Y419-SRC [cytosol]
(R-HSA-8964276)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
0.524
2
UniProt:Q9UQM7 CAMK2A
6
p-T286-CAMK2A [plasma membrane]
(R-HSA-432796)
p-T286-CAMK2A [nucleoplasm]
(R-HSA-444797)
p-T286-CAMK2A [endocytic vesicle membrane]
(R-HSA-416999)
p-T286,T305,T306-CAMK2A [cytosol]
(R-HSA-4332334)
CAMK2A [cytosol]
(R-HSA-4332329)
p-T286-CAMK2A [cytosol]
(R-HSA-445368)
0.519
2
UniProt:Q9BYB0 SHANK3
1
SHANK3 [cytosol]
(R-HSA-6794277)
0.508
2
UniProt:Q13936 CACNA1C
1
CACNA1C [plasma membrane]
(R-HSA-265551)
0.508
2
UniProt:Q15599 NHRF2
0.508
2
UniProt:Q96QS3 ARX
0.508
2
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE
0.462
2
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE
0.462
2
UniProt:P08567 PLEK
2
PLEK [extracellular region]
(R-HSA-350741)
PLEK [cytosol]
(R-HSA-350715)
0.462
2
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