Reactome | ACTN1 [cytosol]

ACTN1 [cytosol]

Stable Identifier

R-HSA-354096

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Alpha-actinin 1

Locations in the PathwayBrowser for interactor UniProt:P00973 OAS1

Expand all

External Reference Information

External Reference

UniProt:P12814 ACTN1

Gene Names

ACTN1

Chain

chain:1-892

Reference Genes

BioGPS Gene:87 ACTN1

COSMIC (genes):ACTN1 ACTN1

CTD Gene:87 ACTN1

dbSNP Gene:87 ACTN1

ENSEMBL:ENSG00000072110 ACTN1

HGNC:163 ACTN1

KEGG:hsa:87 ACTN1

Monarch:87 ACTN1

NCBI Gene:87 ACTN1

OMIM:102575 ACTN1

UCSC:P12814 ACTN1

Reference Transcript

Other Identifiers

11728374_s_at

11728375_x_at

11743969_s_at

11743970_x_at

11751116_a_at

11751117_x_at

200943_PM_at

200943_at

208636_PM_at

208636_at

208637_PM_x_at

208637_x_at

211160_PM_x_at

211160_x_at

3552005

3569813

3569815

3569816

3569817

3569818

3569819

3569820

3569821

3569822

3569823

3569825

3569826

3569827

3569828

3569829

3569830

3569831

3569832

3569834

3569835

3569836

3569837

3569838

3569840

3569841

3569842

3569843

3569844

3569846

3569847

3569848

3569849

3569850

3569851

3569855

3569856

3569857

3569858

3569859

3569860

3569862

3569864

3569865

3569866

3569869

3569871

3569872

3569873

3569881

3569893

3569898

3569899

3569902

3569903

3569904

3569905

3569906

3569907

3569908

3569909

3569910

3932273

3932288

39329_at

39330_s_at

3945053

3996710

7979824

A_23_P105957

A_24_P107695

GE512729

GE61093

GE84738

GO:0001725

GO:0001726

GO:0003723

GO:0003725

GO:0003779

GO:0005178

GO:0005198

GO:0005509

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0005903

GO:0005911

GO:0005916

GO:0005925

GO:0006355

GO:0007010

GO:0007015

GO:0008092

GO:0017166

GO:0030017

GO:0030018

GO:0030036

GO:0030054

GO:0030154

GO:0030220

GO:0030374

GO:0030864

GO:0031093

GO:0031143

GO:0034330

GO:0036344

GO:0042803

GO:0042981

GO:0042995

GO:0043226

GO:0044325

GO:0045893

GO:0046872

GO:0048041

GO:0048856

GO:0051015

GO:0051017

GO:0051639

GO:0055001

GO:0060090

GO:0070062

GO:0070161

GO:0098978

GO:0099173

GO:0099186

GO:0140110

HMNXSV003005404

Hs.119000.1.S2_3p_at

ILMN_2232177

M95178_at

PH_hs_0027789

PH_hs_0031573

TC14001255.hg

TC14002059.hg

g13097755_3p_a_at

Participates

as a candidate of

as a component of

as an input of

as a member of

Alpha-actinin [cytosol] (Homo sapiens)

Other forms of this molecule

ACTN1 [platelet alpha granule lumen]

ACTN1 [extracellular region]

Inferred To

atn-1 [cytosol] (Caenorhabditis elegans)

ain1 [cytosol] (Schizosaccharomyces pombe)

abpD [cytosol] (Dictyostelium discoideum)

ACTN1 [cytosol] (Bos taurus)

ACTN1 [cytosol] (Canis familiaris)

ACTN1 [cytosol] (Dictyostelium discoideum)

ACTN1 [cytosol] (Drosophila melanogaster)

ACTN1 [cytosol] (Gallus gallus)

ACTN1 [cytosol] (Mus musculus)

ACTN1 [cytosol] (Sus scrofa)

Homologues of ACTN1 [cytosol] (Dictyostelium discoideum)

Homologues of ACTN1 [cytosol] (Drosophila melanogaster)

Actn1 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001123476.1, NP_001093.1, NP_001123477.1

OpenTargets

ENSG00000072110

ENSEMBL

ENST00000394419, ENSP00000377941, ENST00000193403, ENST00000538545, ENSP00000414272, ENSP00000439828, ENST00000438964, ENSP00000193403

HPA

ENSG00000072110-ACTN1

PRO

P12814

Pharos - Targets

P12814

GlyGen

P12814

Orphanet

ACTN1

PDB

2EYI, 2N8Y, 2N8Z, 2EYN

Interactors (42)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NPC6 MYOZ2			0.805	11
UniProt:Q7L775 EPMIP			0.718	6
UniProt:Q8IY33 MILK2			0.718	6
UniProt:P00973 OAS1	1	OAS1 [cytosol] (R-HSA-947486)	0.666	4
UniProt:Q9NP98 MYOZ1			0.666	4
UniProt:Q9NWQ9 CN119			0.666	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	19
UniProt:P27958-PRO_0000037577			0.611	7
UniProt:Q9Y223 GNE	9	GNE V572L [cytosol] (R-HSA-4088323) GNE M712T [cytosol] (R-HSA-4088386) GNE R263L [cytosol] (R-HSA-4088402) GNE R266W [cytosol] (R-HSA-4088372) GNE R266Q [cytosol] (R-HSA-4088390) GNE A631V [cytosol] (R-HSA-4088376) GNE M171V [cytosol] (R-HSA-4088351) GNE C303V [cytosol] (R-HSA-4088366) GNE [cytosol] (R-HSA-3781927)	0.591	3
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.569	6
UniProt:Q8N3V7 SYNPO			0.564	2
UniProt:O75604 USP2	2	USP2 [cytosol] (R-HSA-5212661) USP2 [nucleoplasm] (R-HSA-5689946)	0.556	3
UniProt:P10599 TXN	4	TXN [cytosol] (R-HSA-66000) 2xHC-TXN [cytosol] (R-HSA-73668) TXN [nucleoplasm] (R-HSA-9617732) 2xHC-TXN [nucleoplasm] (R-HSA-9617733)	0.556	3
UniProt:Q8NC69 KCTD6	1	KCTD6 [cytosol] (R-HSA-8863321)	0.556	3
UniProt:Q08043 ACTN3	1	ACTN3 [cytosol] (R-HSA-390565)	0.556	3
UniProt:P00973-2 OAS1			0.556	3
UniProt:Q8NA61 CBY2			0.556	3
UniProt:O95257 GA45G			0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:Q9H987-2 SYNPO2L			0.556	3
UniProt:A0A0S2Z4Y0 A0A0S2Z4Y0			0.556	3
UniProt:Q92624 APBP2			0.556	3
UniProt:Q6ZUT1 NKAP1			0.556	3
UniProt:P35609 ACTN2	3	ACTN2 [cytosol] (R-HSA-390562) ACTN2 [platelet alpha granule lumen] (R-HSA-349727) ACTN2 [extracellular region] (R-HSA-349725)	0.556	3
UniProt:P50479 PDLI4			0.556	3
UniProt:P63172 DYNLT1	3	DYNLT1 [ficolin-1-rich granule lumen] (R-HSA-6801487) DYNLT1 [extracellular region] (R-HSA-6806509) DYNLT1 [secretory granule lumen] (R-HSA-6801497)	0.556	3
UniProt:B2R8Y4 B2R8Y4			0.556	3
UniProt:P05198 EIF2S1	2	EIF2S1 [cytosol] (R-HSA-72510) p-S52-EIF2S1 [cytosol] (R-HSA-381060)	0.556	3
UniProt:P12814 ACTN1	3	ACTN1 [cytosol] (R-HSA-354096) ACTN1 [platelet alpha granule lumen] (R-HSA-349724) ACTN1 [extracellular region] (R-HSA-349722)	0.553	2
UniProt:Q8VC66 ADIP			0.544	3
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.527	3
UniProt:Q9NR12 PDLIM7	1	PDLIM7 [cytosol] (R-HSA-8855085)	0.527	5
UniProt:Q92731 ESR2	5	ESR2 [cytosol] (R-HSA-9020970) ESR2 [nucleoplasm] (R-HSA-446165) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787) PalmS-ESR2 [plasma membrane] (R-HSA-9021059) PalmS-ESR2 [cytosol] (R-HSA-9020979)	0.527	2
UniProt:P12931 SRC	6	MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-SRC [plasma membrane] (R-HSA-8876922) p-Y419-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690)	0.524	2
UniProt:Q9UQM7 CAMK2A	6	p-T286-CAMK2A [cytosol] (R-HSA-445368) CAMK2A [cytosol] (R-HSA-4332329) p-T286-CAMK2A [endocytic vesicle membrane] (R-HSA-416999) p-T286,T305,T306-CAMK2A [cytosol] (R-HSA-4332334) p-T286-CAMK2A [nucleoplasm] (R-HSA-444797) p-T286-CAMK2A [plasma membrane] (R-HSA-432796)	0.519	2
UniProt:Q96QS3 ARX			0.508	2
UniProt:Q15599 NHRF2			0.508	2
UniProt:Q13936 CACNA1C	1	CACNA1C [plasma membrane] (R-HSA-265551)	0.508	2
UniProt:Q9BYB0 SHANK3	1	SHANK3 [cytosol] (R-HSA-6794277)	0.508	2
UniProt:P08567 PLEK	2	PLEK [extracellular region] (R-HSA-350741) PLEK [cytosol] (R-HSA-350715)	0.462	2
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE			0.462	2
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE			0.462	2

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