Reactome | FLNB [cytosol]

FLNB [cytosol]

Stable Identifier

R-HSA-354163

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Filamin-B

Locations in the PathwayBrowser for interactor UniProt:Q9Y6R4 M3K4

Expand all

External Reference Information

External Reference

UniProt:O75369 FLNB

Gene Names

FLNB, FLN1L, FLN3, TABP, TAP

Chain

chain:1-2602

Reference Genes

BioGPS Gene:2317 FLNB

COSMIC (genes):FLNB FLNB

CTD Gene:2317 FLNB

dbSNP Gene:2317 FLNB

ENSEMBL:ENSG00000136068 FLNB

ENSEMBL_homo_sapiens_GENE:ENSG00000136068.16 FLNB

HGNC:3755 FLNB

KEGG Gene (Homo sapiens):2317 FLNB

Monarch:2317 FLNB

NCBI Gene:2317 FLNB

OMIM:603381 FLNB

UCSC:O75369 FLNB

Reference Transcript

Other Identifiers

11754357_a_at

11756230_a_at

16942103

208613_PM_s_at

208613_s_at

208614_PM_s_at

208614_s_at

2317

2625917

2625918

2625957

2625961

2625962

2625967

2625968

2625971

2625972

2625975

2625978

2625979

2625981

2625986

2625988

2625990

2625993

2625994

2625995

2625996

2626003

2626008

2626009

2626010

2626012

2626013

2626016

2626019

2626021

2626023

2626024

2626025

2626027

2626028

2626030

2626032

2626034

2626035

2626036

2626037

2626040

2626042

2626045

2626046

2626047

2626049

2626052

2626055

2626064

2626065

2626067

2626069

2626070

2626071

2626072

2626073

2626074

2626075

3415097

3415100

3656900

3656901

38078_at

8080714

A_14_P120947

A_23_P211878

GE54373

GO:0001725

GO:0002376

GO:0003334

GO:0003382

GO:0003723

GO:0003779

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0005903

GO:0005925

GO:0005938

GO:0007010

GO:0007165

GO:0007517

GO:0007519

GO:0008092

GO:0015629

GO:0016020

GO:0023052

GO:0030018

GO:0030036

GO:0030154

GO:0031410

GO:0042802

GO:0043226

GO:0043232

GO:0045296

GO:0045335

GO:0048856

GO:0051015

GO:0070062

GO:0071346

GO:0098542

HMNXSV003029787

HMNXSV003056778

Hs.81008.0.A1_3p_a_at

ILMN_1664922

M62994_at

PH_hs_0004652

TC03000375.hg

g349450_3p_a_at

Participates

as a component of

ISGylated Filamin B [cytosol] (Homo sapiens)

as an input of

ISGylation of host protein filamin B (Homo sapiens)

Inferred To

cher [cytosol] (Drosophila melanogaster)

fln-1 [cytosol] (Caenorhabditis elegans)

Flnb [cytosol] (Mus musculus)

Flnb [cytosol] (Rattus norvegicus)

abpC [cytosol] (Dictyostelium discoideum)

FLNB [cytosol] (Bos taurus)

FLNB [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001448.2, NP_001157791.1, NP_001157789.1, NP_001157790.1

OpenTargets

ENSG00000136068

HPA

ENSG00000136068-FLNB

GeneCards

O75369

Ensembl

ENST00000490882, ENST00000295956, ENSG00000136068, ENSP00000351339, ENSP00000420213, ENST00000429972, ENSP00000295956, ENST00000358537, ENSP00000415599

PRO

O75369

Pharos - Targets

O75369

Orphanet

16059

PDB

2E9I, 2DMC, 2WA7, 2DMB, 2DLG, 2WA6, 2EE9, 2WA5, 2EEC, 3FER, 2DIC, 2EEB, 2DI9, 2DI8, 5DCP, 2EE6, 2DIB, 2E9J, 4B7L, 2EEA, 2DIA, 2EED, 2DJ4

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	21
UniProt:P05161 ISG15	4	ISG15 [nucleoplasm] (R-HSA-5653665) K164-PCNA-G157-ISG15 [nucleoplasm] (R-HSA-5653745) ISG15 [cytosol] (R-HSA-936552) K168-PCNA-G157-ISG15 [nucleoplasm] (R-HSA-5653744)	0.591	4
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.564	2
UniProt:P21333 FLNA	3	FLNA [extracellular region] (R-HSA-350712) p-S2152-FLNA [cytosol] (R-HSA-5669246) FLNA [cytosol] (R-HSA-210019)	0.543	5
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P49768 PSEN1	6	PSEN1(1-467) [plasma membrane] (R-HSA-201606) PSEN1(299-467) [azurophil granule membrane] (R-HSA-6799234) PSEN1(1-467) [azurophil granule membrane] (R-HSA-6799235) PSEN1(1-298) [azurophil granule membrane] (R-HSA-6799209) PSEN1(1-298) [plasma membrane] (R-HSA-2534298) PSEN1(299-467) [plasma membrane] (R-HSA-2534245)	0.508	2
UniProt:P49810 PSEN2	2	PSEN2(1-297) [plasma membrane] (R-HSA-201599) PSEN2(298-448) [plasma membrane] (R-HSA-9013329)	0.508	2
UniProt:Q9Y6R4 M3K4			0.499	2
UniProt:Q13233 MAP3K1	2	MAP3K1 [cytosol] (R-HSA-166866) p-T1400,T1412-MAP3K1 [cytosol] (R-HSA-2685607)	0.499	2
UniProt:P63000 RAC1	6	RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076) RAC1 [cytosol] (R-HSA-442615) RAC1 [plasma membrane] (R-HSA-351141)	0.499	2
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE			0.462	2
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE			0.462	2

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