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Interaction of SOS with GRB2 bound to FADK1
Stable Identifier
R-HSA-354165
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Platelet Aggregation (Plug Formation) (Homo sapiens)
Integrin signaling (Homo sapiens)
GRB2:SOS provides linkage to MAPK signaling for Integrins (Homo sapiens)
Interaction of SOS with GRB2 bound to FADK1 (Homo sapiens)
Signal Transduction (Homo sapiens)
Integrin signaling (Homo sapiens)
GRB2:SOS provides linkage to MAPK signaling for Integrins (Homo sapiens)
Interaction of SOS with GRB2 bound to FADK1 (Homo sapiens)
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Son of sevenless protein homolog 1(SOS) is an activating nucleotide exchange factor for H-Ras (p21Ras). SOS is brought close to the H-Ras by interacting with the FADK1 bound GRB2.
Participants
Input
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane]
(Homo sapiens)
SOS1 [cytosol]
(Homo sapiens)
Output
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane]
(Homo sapiens)
Participates
as an event of
GRB2:SOS provides linkage to MAPK signaling for Integrins (Homo sapiens)
Orthologous Events
Interaction of SOS with GRB2 bound to FADK1 (Bos taurus)
Interaction of SOS with GRB2 bound to FADK1 (Caenorhabditis elegans)
Interaction of SOS with GRB2 bound to FADK1 (Canis familiaris)
Interaction of SOS with GRB2 bound to FADK1 (Gallus gallus)
Interaction of SOS with GRB2 bound to FADK1 (Mus musculus)
Interaction of SOS with GRB2 bound to FADK1 (Rattus norvegicus)
Interaction of SOS with GRB2 bound to FADK1 (Sus scrofa)
Authored
Garapati, P V (2008-06-16)
Reviewed
Shattil, SJ (2008-09-16)
Created
Garapati, P V (2008-06-16)
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