Reactome | LYN [cytosol]

LYN [cytosol]

Stable Identifier

R-HSA-354251

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tyrosine-protein kinase LYN, LYN_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:Q8R5G7

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External Reference Information

External Reference

UniProt:P07948 LYN

Gene Names

LYN, JTK8

Chain

initiator methionine:, chain:2-512

Reference Genes

COSMIC (genes):LYN LYN

dbSNP Gene:4067 LYN

ENSEMBL:ENSG00000254087 LYN

Participates

as a component of

as an input of

PIK3R1:PIK3CA,B,D (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated (Homo sapiens)
Growth hormone receptor binds Lyn (Homo sapiens)
GPVI binds Fyn and Lyn (Homo sapiens)

as a candidate of

FYN-like kinases [cytosol] (Homo sapiens)

as a member of

Other forms of this molecule

MyrG2-PalmC3-LYN [plasma membrane]

p-Y397-LYN [plasma membrane]

p-Y397-LYN [cytosol]

LYN [plasma membrane]

MyrG2-PalmC3-LYN [endocytic vesicle membrane]

MyrG2-PalmC3-LYN [lysosomal membrane]

Inferred To

Lyn [cytosol] (Mus musculus)

Lyn [cytosol] (Rattus norvegicus)

Ghost homologue of LYN [cytosol] (Danio rerio)

LYN [cytosol] (Bos taurus)

LYN [cytosol] (Caenorhabditis elegans)

LYN [cytosol] (Canis familiaris)

LYN [cytosol] (Drosophila melanogaster)

LYN [cytosol] (Gallus gallus)

LYN [cytosol] (Sus scrofa)

LYN [cytosol] (Xenopus tropicalis)

Interactors (44)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.82	7
UniProt:P27958 POLG	1	POLG [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HCV-8854138)	0.704	4
UniProt:P12931 SRC	6	MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-SRC [plasma membrane] (R-HSA-8876922) p-Y419-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690)	0.669	4
UniProt:Q9WMX2 POLG			0.667	3
UniProt:Q9HCN6 GP6	1	GP6 [plasma membrane] (R-HSA-114574)	0.641	5
UniProt:Q9NWQ8 PAG1	2	PAG1 [plasma membrane] (R-HSA-180500) p-Y317-PAG1 [plasma membrane] (R-HSA-180494)	0.641	16
UniProt:Q13444 ADAM15	1	ADAM15 [plasma membrane] (R-HSA-708329)	0.609	2
UniProt:Q07666 KHDRBS1	3	p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm] (R-HSA-8848970) p-Y435,Y440,Y443-KHDRBS1 [cytosol] (R-HSA-8848995) KHDRBS1 [nucleoplasm] (R-HSA-8848941)	0.609	2
UniProt:Q8NDB2 BANK1			0.591	3
UniProt:O92972 POLG			0.589	2
UniProt:Q05397 PTK2	11	p-6Y-PTK2 [cytosol] (R-HSA-354128) p-Y397-PTK2 [cytosol] (R-HSA-354068) PTK2 [cytosol] (R-HSA-201621) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2(773-1052) [cytosol] (R-HSA-202829) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) pY-PTK2 [cytosol] (R-HSA-9632393) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613)	0.573	2
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL [cytosol] (R-HSA-112199) p-Y371-CBL [cytosol] (R-HSA-182940) p-Y700,Y731,Y774-CBL [cytosol] (R-HSA-912656)	0.564	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.564	2
UniProt:O43184 ADAM12	1	ADAM12 [plasma membrane] (R-HSA-179792)	0.558	2
UniProt:Q8R5G7	1	Arap3 [cytosol] (R-MMU-195185)	0.558	2
UniProt:P22575 TIP			0.558	3
UniProt:P37840 SNCA	5	SNCA [cytosol] (R-HSA-5658500) p-S129-SNCA [cytosol] (R-HSA-9836432) Ub-SNCA [cytosol] (R-HSA-5660754) SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569)	0.556	3
UniProt:Q9BS26 ERP44	2	ERP44 [extracellular region] (R-HSA-6806302) ERP44 [specific granule lumen] (R-HSA-6799567)	0.556	3
UniProt:P27986-2 PIK3R1			0.556	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:P07602 PSAP	11	PSAP(326-340) [extracellular region] (R-HSA-5336179) PSAP(?-?) [extracellular region] (R-HSA-5336190) PSAP(17-524) [azurophil granule membrane] (R-HSA-6799212) PSAP(17-524) [plasma membrane] (R-HSA-6806262) PSAP(195-273) [lysosomal lumen] (R-HSA-9840336) PSAP [lysosomal lumen] (R-HSA-9840325) PSAP(60-142) [lysosomal lumen] (R-HSA-351333) PSAP(311-391) [lysosomal membrane] (R-HSA-1605602) PSAP(405-486) [lysosomal lumen] (R-HSA-9840328) PSAP(311-391) [lysosomal lumen] (R-HSA-9851355) PSAP(60-142) [extracellular region] (R-HSA-351338)	0.556	3
UniProt:P01023 A2M	2	A2M [extracellular region] (R-HSA-49291) A2M [platelet alpha granule lumen] (R-HSA-139834)	0.556	3
UniProt:Q96GW7 BCAN	20	D2,4,4(S)3-BCAN(361-911) [extracellular region] (R-HSA-3791190) CSE-BCAN(361-911) [extracellular region] (R-HSA-3791188) C6S-BCAN(361-911) [extracellular region] (R-HSA-3791186) C4S-BCAN(361-911) [extracellular region] (R-HSA-3791182) D2,4(S)2-BCAN(361-911) [extracellular region] (R-HSA-3791181) D4S-BCAN(361-911) [extracellular region] (R-HSA-3791193) D4S-BCAN(23-360) [extracellular region] (R-HSA-3791191) D2,4(S)2-BCAN(23-360) [extracellular region] (R-HSA-3791189) C6S-BCAN(23-360) [extracellular region] (R-HSA-3791184) D2,4,4(S)3-BCAN(23-360) [extracellular region] (R-HSA-3791180) C4S-BCAN(23-360) [extracellular region] (R-HSA-3791179) CSE-BCAN(23-360) [extracellular region] (R-HSA-3791192) D2,4(S)2-BCAN(23-395) [extracellular region] (R-HSA-3791174) D2,4,4(S)3-BCAN(23-395) [extracellular region] (R-HSA-3791127) C6S-BCAN(23-395) [extracellular region] (R-HSA-3791162) C4S-BCAN(23-395) [extracellular region] (R-HSA-3791130) D4S-BCAN(23-395) [extracellular region] (R-HSA-3791147) CSE-BCAN(23-395) [extracellular region] (R-HSA-3791131) C4S-BCAN(396-911) [extracellular region] (R-HSA-3791157) D2,4,4(S)3-BCAN(396-911) [extracellular region] (R-HSA-3791170)	0.556	3
UniProt:Q96L34 MARK4	1	MARK4 [cytosol] (R-HSA-5626653)	0.556	3
UniProt:P51608 MECP2			0.556	3
UniProt:P50570-2 DNM2			0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [plasma membrane] (R-HSA-5658225) SPRED1 [cytosol] (R-HSA-5654207)	0.556	3
UniProt:P46527 CDKN1B	8	p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) CDKN1B [nucleoplasm] (R-HSA-182563) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) CDKN1B [cytosol] (R-HSA-198622) p-T157-CDKN1B [cytosol] (R-HSA-198629) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-S10 CDKN1B [cytosol] (R-HSA-9632829)	0.544	2
UniProt:O95684 CEP43	3	FGFR1OP(2-163)-FGFR1(429-822) fusion [cytosol] (R-HSA-1604533) FGFR1OP(2-163)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1838994) FGFR1OP [cytosol] (R-HSA-380309)	0.527	2
UniProt:P08631 HCK	2	p-HCK [cytosol] (R-HSA-9676060) HCK [cytosol] (R-HSA-167708)	0.527	3
UniProt:P06239 LCK	4	LCK [cytosol] (R-HSA-167609) p-Y394-LCK [cytosol] (R-HSA-202308) p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [plasma membrane] (R-HSA-8857940)	0.527	2
UniProt:P09769 FGR	3	FGR [cytosol] (R-HSA-432116) FGR [secretory granule lumen] (R-HSA-6804974) FGR [extracellular region] (R-HSA-6806524)	0.527	3
UniProt:Q9NQW6 ANLN	1	ANLN [cytosol] (R-HSA-9690261)	0.527	2
UniProt:Q9HCN6-1 GP6			0.524	2
UniProt:Q15642 TRIP10	1	TRIP10 [cytosol] (R-HSA-195120)	0.508	2
UniProt:P16671 CD36	5	4xPalmC-CD36 [plasma membrane] (R-HSA-51645) 4xPalmC-CD36 [specific granule membrane] (R-HSA-6806151) 4xPalmC-CD36 [endocytic vesicle membrane] (R-HSA-2239449) CD36 [phagocytic vesicle] (R-HSA-1236835) CD36 [platelet alpha granule membrane] (R-HSA-114687)	0.499	3
UniProt:Q6UWF3 SCIMP			0.499	3
UniProt:Q08857 Cd36	6	Cd36 [plasma membrane] (R-MMU-51645) Cd36 [plasma membrane] (R-MMU-2187219) Cd36 [specific granule membrane] (R-MMU-6806151) Cd36 [endocytic vesicle membrane] (R-MMU-2239449) Cd36 [phagocytic vesicle] (R-MMU-1236835) Cd36 [platelet alpha granule membrane] (R-MMU-114687)	0.499	2
UniProt:P11049 CD37			0.499	5
UniProt:P14317 HCLS1			0.499	2
UniProt:P20273 CD22	3	p-Y762,807,822-CD22 [plasma membrane] (R-HSA-5690726) CD22 [plasma membrane] (R-HSA-197703) NAc-CD22 [plasma membrane] (R-HSA-5690736)	0.499	2
UniProt:P33993 MCM7	1	MCM7 [nucleoplasm] (R-HSA-68555)	0.499	4
UniProt:P25063 CD24	1	CD24(29-534) [plasma membrane] (R-HSA-430062)	0.499	6
UniProt:P61980	2	Hnrnpk [nucleoplasm] (R-RNO-4570532) Hnrnpk [nucleoplasm] (R-RNO-71945)	0.469	2

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