Reactome | TNKS2 [cytosol]

TNKS2 [cytosol]

Stable Identifier

R-HSA-3640824

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ub-specific processing proteases (Homo sapiens)
      - USP34 deubiquitinates AXIN1,AXIN2 (Homo sapiens)
        
        RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
        
        RibC-AXIN:TNKS [cytosol] (Homo sapiens)
        
        TNKS1/2 [cytosol] (Homo sapiens)
        
        TNKS2 [cytosol] (Homo sapiens)
        
        Ub-RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
        
        TNKS1/2 [cytosol] (Homo sapiens)
        
        TNKS2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9H2K2 TNKS2

Gene Names

TNKS2, PARP5B, TANK2, TNKL

Chain

chain:1-1166

Reference Genes

BioGPS Gene:80351 TNKS2

COSMIC (genes):TNKS2 TNKS2

CTD Gene:80351 TNKS2

dbSNP Gene:80351 TNKS2

ENSEMBL:ENSG00000107854 TNKS2

HGNC:15677 TNKS2

KEGG:hsa:80351 TNKS2

Monarch:80351 TNKS2

NCBI Gene:80351 TNKS2

OMIM:607128 TNKS2

UCSC:Q9H2K2 TNKS2

Reference Transcript

RefSeq:NM_025235.3 TNKS2

Other Identifiers

11722461_a_at

11722462_a_at

11722463_a_at

11757893_s_at

16707379

218228_PM_s_at

218228_s_at

222562_PM_s_at

222562_s_at

222563_PM_s_at

222563_s_at

3257851

3257852

3257853

3257854

3257862

3257863

3257865

3257866

3257868

3257869

3257871

3257874

3257875

3257879

3257881

3257883

3257884

3257885

3257887

3257889

3257891

3257896

3257898

3257902

3257903

3257904

3257905

3257908

3257909

3257910

3257911

3257913

3257915

3257916

3257917

3257918

3257919

3257920

54706_at

54708_at

7929168

80351

A_14_P116106

A_14_P139894

A_23_P12620

GE61733

GE79043

GO:0000139

GO:0000209

GO:0000242

GO:0000781

GO:0003824

GO:0003950

GO:0005515

GO:0005634

GO:0005635

GO:0005694

GO:0005737

GO:0005794

GO:0005829

GO:0016020

GO:0016055

GO:0016740

GO:0016757

GO:0016779

GO:0019899

GO:0032212

GO:0043226

GO:0046872

GO:0048471

GO:0070198

GO:0070212

GO:0070213

GO:0090263

GO:0140096

GO:1904355

GO:1904357

GO:1990404

HMNXSV003033311

Hs.280776.0.S2_3p_a_at

PH_hs_0014453

TC10000654.hg

g13161041_3p_a_at

g13376841_3p_a_at

Participates

as a member of

TNKS1/2 [cytosol] (Homo sapiens)

Inferred To

Tnks2 [cytosol] (Rattus norvegicus)

TNKS2 [cytosol] (Bos taurus)

TNKS2 [cytosol] (Canis familiaris)

TNKS2 [cytosol] (Gallus gallus)

TNKS2 [cytosol] (Mus musculus)

Cross References

RefSeq

NP_079511.1

ZINC - World Drugs

TNKS2_HUMAN

Guide to Pharmacology - Targets

3109

OpenTargets

ENSG00000107854

ENSEMBL

ENST00000371627, ENSP00000360689

ZINC - FDA approved

TNKS2_HUMAN

ZINC - Substances

TNKS2_HUMAN

ZINC - Biogenic

TNKS2_HUMAN

ZINC target

Q9H2K2

PRO

Q9H2K2

PDB

4UI5, 4L33, 5FPF, 6TKM, 4L2K, 4TK5, 4UHG, 5FPG, 3KR8, 4BU3, 4J3M, 4UVL, 3TWR, 4HLG, 4BJ9, 4KZU, 4BUU, 4L0T, 3TWU, 4AVU, 5AL5, 4HMH, 5NUT, 4J1Z, 4BUX, 5ADR, 5AL1, 7A1S, 5NSP, 4PNM, 4J22, 4UVX, 4UFU, 4HYF, 6TKS, 3TWW, 4L2F, 4TKG, 4IUE, 3U9Y, 4HKN, 4BUE, 4UI6, 2Y0I, 5DCZ, 4L34, 5C5R, 4HKI, 4BU5, 4BUA, 4PNS, 4UI3, 4HLM, 4AVW, 4UVT, 3TWS, 5AKU, 4BU8, 4UX4, 5AL3, 4BUV, 4L0V, 3U9H, 5ADQ, 4L0B, 4L0I, 4PNQ, 4UVV, 3UA9, 4PNN, 4L09, 4UVY, 4M7B, 3TWV, 5NOB, 6TKP, 4TK0, 3MHK, 4L32, 4L2G, 4Z68, 4BUF, 4UI7, 6TKN, 4BU9, 4BU6, 3KR7, 4PNT, 5BXU, 5AL4, 3TWT, 4HLF, 5OWS, 5ADT, 5JRT, 4HLK, 4BUI, 4UVN, 4UVZ, 4BUS, 5ADS, 4BUY, 4UFY, 4UVO, 4BFP, 8ALY, 5AEH, 3TWX, 3P0P, 4BJB, 3W51, 4PNL, 4HKK, 4TJU, 4TKF, 4TJW, 4HL5, 6TKR, 5C5P, 7R3Z, 4J3L, 4BUD, 4W5I, 4UI4, 5BXO, 4UI8, 4KZQ, 5OWT, 4BU7, 4PNR, 4UVP, 4L0S, 4KZL, 5AL2, 4L10, 4UVS, 3P0Q, 5AKW, 4BUW, 4BUT, 4HLH, 4PML, 7O6X, 3TWQ, 4BS4, 3P0N, 4J21, 4UVW, 7POX, 6TG4, 4TKI, 4TJY, 4BJC, 4UVU, 5C5Q, 3MHJ, 4L31, 6TKQ

ZINC - Metabolites

TNKS2_HUMAN

IntEnz

2.4.2.30

HPA

ENSG00000107854-TNKS2

Pharos - Targets

Q9H2K2

ZINC - Predictions - Purchasable

TNKS2_HUMAN

HMDB Protein

HMDBP00901

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NWV8 BABAM1	2	BABAM1 [cytosol] (R-HSA-5691418) BABAM1 [nucleoplasm] (R-HSA-5682582)	0.757	7
UniProt:P14652 HOXB2	1	HOXB2 [nucleoplasm] (R-HSA-5617487)	0.693	3
UniProt:O60547 GMDS	1	GMDS [cytosol] (R-HSA-6787620)	0.527	2
UniProt:Q07954 LRP1	2	LRP1 [endocytic vesicle membrane] (R-HSA-2230981) LRP1 [plasma membrane] (R-HSA-1454844)	0.527	2
UniProt:O43815 STRN	5	STRN [cytosol] (R-HSA-9037081) STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673902) p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673908) STRN(1-137)-ALK(1058-1620) fusion [cytosol] (R-HSA-9700485) STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9700467)	0.525	2