Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
RNF146 [cytosol]
Stable Identifier
R-HSA-3640827
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
USP34 deubiquitinates AXIN1,AXIN2 (Homo sapiens)
RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
RNF146 [cytosol] (Homo sapiens)
Ub-RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
RNF146 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN stability and activity (Homo sapiens)
RNF146 polyubiquitinates PARylated PTEN (Homo sapiens)
RNF146 [cytosol] (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Degradation of AXIN (Homo sapiens)
RNF146 binds RibC-AXIN:TNKS complex (Homo sapiens)
RNF146 [cytosol] (Homo sapiens)
RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
RNF146 [cytosol] (Homo sapiens)
RNF146 ubiquitinates ADP-ribosylated AXIN (Homo sapiens)
RNF146 [cytosol] (Homo sapiens)
RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
RNF146 [cytosol] (Homo sapiens)
Ub-RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
RNF146 [cytosol] (Homo sapiens)
Ub-RibC-AXIN is degraded by the proteasome (Homo sapiens)
RNF146 [cytosol] (Homo sapiens)
Ub-RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
RNF146 [cytosol] (Homo sapiens)
USP34 deubiquitinates AXIN1,AXIN2 (Homo sapiens)
RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
RNF146 [cytosol] (Homo sapiens)
Ub-RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
RNF146 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9NTX7 RNF146
Gene Names
RNF146
Chain
chain:1-359
Reference Genes
BioGPS Gene:81847 RNF146
COSMIC (genes):RNF146 RNF146
CTD Gene:81847 RNF146
dbSNP Gene:81847 RNF146
ENSEMBL:ENSG00000118518 RNF146
ENSEMBL_homo_sapiens_GENE:ENSG00000118518.17 RNF146
HGNC:21336 RNF146
KEGG Gene (Homo sapiens):81847 RNF146
Monarch:81847 RNF146
NCBI Gene:81847 RNF146
OMIM:612137 RNF146
UCSC:Q9NTX7 RNF146
Reference Transcript
RefSeq:NM_001242848.1 RNF146
RefSeq:XM_011536161.2 RNF146
RefSeq:XM_011536162.2 RNF146
RefSeq:XM_017011338.1 RNF146
RefSeq:NM_001242847.1 RNF146
RefSeq:XM_006715571.3 RNF146
RefSeq:XM_017011343.1 RNF146
RefSeq:XM_017011337.1 RNF146
RefSeq:XM_017011342.1 RNF146
RefSeq:NM_001242846.1 RNF146
RefSeq:NM_030963.3 RNF146
RefSeq:XM_017011336.1 RNF146
RefSeq:XM_017011341.1 RNF146
RefSeq:NM_001242845.1 RNF146
RefSeq:NM_001242852.1 RNF146
RefSeq:XM_011536164.2 RNF146
RefSeq:NM_001242851.1 RNF146
RefSeq:XM_017011340.1 RNF146
RefSeq:XM_011536163.2 RNF146
RefSeq:NM_001242850.1 RNF146
RefSeq:NM_001242844.1 RNF146
RefSeq:NM_001242849.1 RNF146
RefSeq:XM_017011339.1 RNF146
Other Identifiers
11754525_s_at
17012404
221430_PM_s_at
221430_s_at
223886_PM_s_at
223886_s_at
2924902
2924903
2924904
2924905
2924906
2924918
2924919
2924925
2924926
2924927
2924928
2924929
44839_s_at
48707_at
8121927
81847
A_23_P257201
GE83205
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0006511
GO:0008270
GO:0016055
GO:0016567
GO:0016740
GO:0023052
GO:0030163
GO:0036211
GO:0043226
GO:0046872
GO:0051865
GO:0061630
GO:0070936
GO:0072572
GO:0090263
GO:0140096
HMNXSV003033726
ILMN_1682626
ILMN_1685679
PH_hs_0013703
TC06000969.hg
TC06003040.hg
g12053166_3p_a_at
g13624336_3p_s_at
Participates
as an output of
Ub-RibC-AXIN is degraded by the proteasome (Homo sapiens)
as an input of
RNF146 binds RibC-AXIN:TNKS complex (Homo sapiens)
as a component of
Ub-RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
Inferred To
Rnf146 [cytosol]
(Drosophila melanogaster)
RNF146B [cytosol]
(Bos taurus)
RNF146 [cytosol]
(Caenorhabditis elegans)
RNF146 [cytosol]
(Canis familiaris)
RNF146 [cytosol]
(Danio rerio)
RNF146 [cytosol]
(Gallus gallus)
RNF146 [cytosol]
(Mus musculus)
RNF146 [cytosol]
(Rattus norvegicus)
RNF146 [cytosol]
(Sus scrofa)
RNF146 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001229781.1
,
XP_011534464.1
,
XP_011534465.1
,
NP_001229778.1
,
NP_001229780.1
,
XP_016866831.1
,
NP_001229777.1
,
XP_011534463.1
,
XP_016866825.1
,
XP_016866832.1
,
NP_001229776.1
,
XP_016866827.1
,
NP_001229775.1
,
NP_001229774.1
,
XP_016866826.1
,
NP_112225.2
,
XP_016866829.1
,
XP_016866830.1
,
NP_001229773.1
,
XP_011534466.1
,
XP_006715634.1
,
NP_001229779.1
,
XP_016866828.1
OpenTargets
ENSG00000118518
GeneCards
Q9NTX7
HPA
ENSG00000118518-RNF146
Ensembl
ENSG00000118518
,
ENST00000610153
,
ENST00000608991
,
ENSP00000477168
,
ENST00000368314
,
ENSP00000476814
,
ENSP00000357297
PRO
Q9NTX7
Pharos - Targets
Q9NTX7
PDB
3V3L
,
6CF6
,
2D8T
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O95271 TNKS
1
TNKS [cytosol]
(R-HSA-3640825)
0.734
6
UniProt:P09874 PARP1
4
polySUMO2,3-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551617)
monoSUMO1-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551686)
PAR-PARP1 [nucleoplasm]
(R-HSA-5651713)
PARP1 [nucleoplasm]
(R-HSA-201568)
0.558
4
UniProt:Q9UGJ1 TUBGCP4
1
TUBGCP4 [cytosol]
(R-HSA-379268)
0.556
3
UniProt:Q8N6L0 KASH5
0.556
3
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.556
3
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text