Reactome | TGFBR2 K128Sfs*35 [cytosol]

TGFBR2 K128Sfs*35 [cytosol]

Stable Identifier

R-HSA-3642166

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TGFBR2 Lys128Serfs*35

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by TGF-beta Receptor Complex in Cancer (Homo sapiens)
    - Loss of Function of TGFBR2 in Cancer (Homo sapiens)
      - TGFBR2 MSI Frameshift Mutants in Cancer (Homo sapiens)
        
        Dimeric TGFB1 does not bind TGFBR2 MSI frameshift mutants (Homo sapiens)
        
        TGFBR2 MSI frameshift mutants [cytosol] (Homo sapiens)
        
        TGFBR2 K128Sfs*35 [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
7761852	Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability Fan, RS, Sun, L, Vogelstein, B, Myeroff, L, Wang, J, Kinzler, KW, Parsons, R, Markowitz, S, Zborowska, E, Lutterbaugh, J	Science	1995
7665626	Demonstration that mutation of the type II transforming growth factor beta receptor inactivates its tumor suppressor activity in replication error-positive colon carcinoma cells Sun, L, Willson, JK, Myeroff, L, Gentry, LE, Wang, J, Yang, J, Wang, X, Liang, J, Markowitz, S, Zborowska, E	J. Biol. Chem.	1995

External Reference Information

External Reference

UniProt:P37173 TGFBR2

Gene Names

TGFBR2

Chain

signal peptide:1-22, chain:23-567

Reference Genes

BioGPS Gene:7048 TGFBR2

COSMIC (genes):TGFBR2 TGFBR2

CTD Gene:7048 TGFBR2

dbSNP Gene:7048 TGFBR2

ENSEMBL:ENSG00000163513 TGFBR2

HGNC:11773 TGFBR2

KEGG:hsa:7048 TGFBR2

Monarch:7048 TGFBR2

NCBI Gene:7048 TGFBR2

OMIM:190182 TGFBR2

UCSC:P37173 TGFBR2

Reference Transcript

Other Identifiers

11724682_s_at

11750840_s_at

16938562

1814_at

1815_g_at

207334_PM_s_at

207334_s_at

208944_PM_at

208944_at

2615378

2615379

2615380

2615384

2615393

2615395

2615396

2615401

2615402

2615403

2615407

2615410

2615412

2615413

2615414

2615415

2615423

2615425

60761_at

7048

8078350

A_14_P126005

A_23_P211957

A_23_P337242

D50683_at

GE57247

GE578892

GE85008

GO:0001568

GO:0001569

GO:0001570

GO:0001701

GO:0001837

GO:0001947

GO:0002053

GO:0002088

GO:0002376

GO:0002651

GO:0002663

GO:0002666

GO:0003148

GO:0003149

GO:0003151

GO:0003180

GO:0003181

GO:0003186

GO:0003214

GO:0003274

GO:0003417

GO:0003430

GO:0003824

GO:0004672

GO:0004674

GO:0004675

GO:0005024

GO:0005026

GO:0005515

GO:0005524

GO:0005539

GO:0005576

GO:0005829

GO:0005886

GO:0005901

GO:0006468

GO:0006915

GO:0007155

GO:0007178

GO:0007179

GO:0007219

GO:0007224

GO:0007369

GO:0007420

GO:0007507

GO:0008284

GO:0009410

GO:0009893

GO:0009897

GO:0010468

GO:0010634

GO:0010718

GO:0012501

GO:0016020

GO:0016740

GO:0017002

GO:0019209

GO:0030154

GO:0030324

GO:0032147

GO:0032924

GO:0034713

GO:0034714

GO:0035162

GO:0035909

GO:0038023

GO:0042127

GO:0043011

GO:0043235

GO:0045121

GO:0045766

GO:0046332

GO:0046872

GO:0048185

GO:0048701

GO:0048844

GO:0048856

GO:0050431

GO:0051138

GO:0051216

GO:0051239

GO:0060021

GO:0060089

GO:0060090

GO:0060391

GO:0060395

GO:0060412

GO:0060425

GO:0060433

GO:0060434

GO:0060439

GO:0060440

GO:0060443

GO:0060463

GO:0061520

GO:0062009

GO:0070021

GO:0070723

GO:0071363

GO:0072091

GO:0098772

GO:0140096

GO:0141091

GO:1905007

GO:1905317

GO:1990086

GO:1990428

GO:2000379

GO:2000563

GO:2000736

HMNXSV003024864

ILMN_1726245

ILMN_1744862

ILMN_2384241

PH_hs_0004687

TC03000149.hg

TC03002268.hg

g1827474_3p_at

g4507468_3p_a_at

Participates

as a member of

TGFBR2 MSI frameshift mutants [cytosol] (Homo sapiens)

Other forms of this molecule

TGFBR2 [plasma membrane]

NEDD8-K556,K567-TGFBR2 [plasma membrane]

TGFBR2 K128Afs*3 [cytosol]

TGFBR2 R528C [plasma membrane]

TGFBR2 R528H [plasma membrane]

TGFBR2 D522N [plasma membrane]

TGFBR2 E526Q [plasma membrane]

TGFBR2 Y470D [plasma membrane]

Modified Residues

Name

Replacement of residues 128 to 161 by SLVRLSSCVPVALMSAMTTSSSQKNITPAILTCC

Disease

Name	Identifier	Synonyms
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer
large intestine cancer	DOID:5672	malignant Colorectal tumor, malignant neoplasm of large intestine, NOS, malignant tumor of large intestine (disorder), malignant neoplasm of colon with rectum, malignant neoplasm of large intestine NOS

Cross References

RefSeq

NP_001020018.1, NP_003233.4

ZINC - World Drugs

TGFR2_HUMAN

Guide to Pharmacology - Targets

1795

OpenTargets

ENSG00000163513

ENSEMBL

ENSP00000351905, ENST00000295754, ENST00000359013, ENSP00000295754

ZINC - FDA approved

TGFR2_HUMAN

ZINC - Substances

TGFR2_HUMAN

ZINC - Biogenic

TGFR2_HUMAN

ZINC target

P37173

PRO

P37173

GlyGen

P37173

PDB

5TX4, 5TY4, 4P7U, 2PJY, 3KFD, 5E8V, 7DV6, 8YGZ, 1M9Z, 1PLO, 1KTZ, 5E8Y, 4XJJ, 5E92, 5E91, 5QIN

ZINC - Investigational

TGFR2_HUMAN

COSMIC

COSV55442522

HPA

ENSG00000163513-TGFBR2

Pharos - Targets

P37173

Orphanet

TGFBR2

ZINC - Predictions - Purchasable

TGFR2_HUMAN

HMDB Protein

HMDBP01237

Interactors (94)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P01137 TGFB1	7	TGFB1 [extracellular region] (R-HSA-170838) TGFB1(30-278) [extracellular region] (R-HSA-2395367) TGFB1(30-278) [Golgi lumen] (R-HSA-9736812) TGFB1 [Golgi lumen] (R-HSA-177108) TGFB1(30-390) [Golgi lumen] (R-HSA-114705) TGFB1 [plasma membrane] (R-HSA-5146781) TGFB1(30-278) [platelet alpha granule lumen] (R-HSA-65936)	0.886	11
UniProt:P10600 TGFB3	3	TGFB3 [platelet alpha granule lumen] (R-HSA-65942) TGFB3(21-300) [extracellular region] (R-HSA-2395290) TGFB3 [extracellular region] (R-HSA-114707)	0.765	8
UniProt:Q9H992 MARH7			0.643	5
UniProt:Q8IX30 SCUBE3	3	SCUBE3(?-993) [plasma membrane] (R-HSA-8943967) SCUBE3(21-?) [plasma membrane] (R-HSA-8943978) SCUBE3 [plasma membrane] (R-HSA-8943884)	0.632	6
UniProt:P09471 GNAO1	1	GNAO1 [plasma membrane] (R-HSA-2997536)	0.556	3
UniProt:P15036 ETS2	2	ETS2 [nucleoplasm] (R-HSA-1629811) p-T72-ETS2 [nucleoplasm] (R-HSA-3132735)	0.556	3
UniProt:Q99435-2 NELL2			0.556	3
UniProt:Q969W3 VCF1			0.556	3
UniProt:Q3SY56 SP6			0.556	3
UniProt:Q8NCS7 SLC44A5	1	SLC44A5 [plasma membrane] (R-HSA-444459)	0.556	3
UniProt:Q96BQ3 TRI43			0.556	3
UniProt:O14531 DPYSL4	3	p-S544-DPYSL4 [cytosol] (R-HSA-399808) p-Y-DPYSL4 [cytosol] (R-HSA-399794) DPYSL4 [cytosol] (R-HSA-398126)	0.556	3
UniProt:P48730-2 CSNK1D			0.556	3
UniProt:Q9UMR2 DD19B			0.556	3
UniProt:Q9UHP3 USP25	1	USP25 [cytosol] (R-HSA-5696900)	0.556	3
UniProt:P46977 STT3A	1	STT3A [endoplasmic reticulum membrane] (R-HSA-265023)	0.556	3
UniProt:P06756 ITGAV	3	ITGAV(31-1048) [plasma membrane] (R-HSA-210013) ITGAV(31-1048) [specific granule membrane] (R-HSA-6806145) ITGAV(31-1048) [phagocytic vesicle] (R-HSA-1236773)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P12830 CDH1	8	CDH1(155-882) [plasma membrane] (R-HSA-198003) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(155-750) [plasma membrane] (R-HSA-202940) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) CDH1(701-882) [extracellular region] (R-HSA-2534158) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(732-882) [plasma membrane] (R-HSA-3827997)	0.556	3
UniProt:Q8TAB5 CA216			0.556	3
UniProt:P49184 DNASE1L1	2	DNASE1L1 [extracellular region] (R-HSA-6806320) DNASE1L1 [specific granule lumen] (R-HSA-6799554)	0.556	3
UniProt:Q6NTF9-3 Q6NTF93			0.556	3
UniProt:Q96NA2 RILP	1	RILP [lysosomal membrane] (R-HSA-2213229)	0.556	3
UniProt:P26378-2 P263782			0.556	3
UniProt:Q9BZ95-3 Q9BZ953			0.556	3
UniProt:Q93084-2 Q930842			0.556	3
UniProt:P61966-2 AP1S1			0.556	3
UniProt:Q8NE08 Q8NE08			0.556	3
UniProt:Q4VBR4 Q4VBR4			0.556	3
UniProt:P61513 RPL37A	1	RPL37A [cytosol] (R-HSA-72468)	0.556	3
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.556	3
UniProt:Q16560-2 SNRNP35			0.556	3
UniProt:P54819 AK2	1	AK2 [mitochondrial intermembrane space] (R-HSA-57822)	0.556	3
UniProt:O75874 IDH1	10	IDH1 [cytosol] (R-HSA-389549) IDH1 [peroxisomal matrix] (R-HSA-389546) IDH1 [secretory granule lumen] (R-HSA-6800980) IDH1 [extracellular region] (R-HSA-6806433) IDH1 [tertiary granule lumen] (R-HSA-6800163) IDH1 [ficolin-1-rich granule lumen] (R-HSA-6800977) IDH1 R132C mutant [cytosol] (R-HSA-880031) IDH1 R132S mutant [cytosol] (R-HSA-880048) IDH1 R132L mutant [cytosol] (R-HSA-880000) IDH1 R132H mutant [cytosol] (R-HSA-880015)	0.556	3
UniProt:P19544-6 WT1			0.556	3
UniProt:Q6PI98 INO80C	1	INO80C [nucleoplasm] (R-HSA-5689605)	0.556	3
UniProt:Q8TBE0 BAHD1			0.556	3
UniProt:P23276 KEL	1	KEL [plasma membrane] (R-HSA-5694121)	0.556	3
UniProt:Q9NP61 ARFGAP3	1	ARFGAP3 [cytosol] (R-HSA-6807740)	0.556	3
UniProt:Q8NC51 SERB1			0.556	3
UniProt:P52756 RBM5	1	RBM5 [nucleoplasm] (R-HSA-72049)	0.556	3
UniProt:Q8TAT6 NPLOC4	2	NPLOC4 [nucleoplasm] (R-HSA-5654987) NPLOC4 [cytosol] (R-HSA-9755492)	0.556	3
UniProt:Q9Y228 T3JAM			0.556	3
UniProt:O75143-2 O751432			0.556	3
UniProt:Q14728 MFS10			0.556	3
UniProt:P54253 ATX1			0.556	3
UniProt:Q9ULR0 ISY1	1	ISY1 [nucleoplasm] (R-HSA-6781963)	0.556	3
UniProt:Q96IY1 NSL1	1	NSL1 [cytosol] (R-HSA-375309)	0.556	3
UniProt:Q16549 PCSK7			0.556	3
UniProt:Q99720-4 SIGMAR1			0.556	3
UniProt:Q16586 SGCA	3	SGCA [endoplasmic reticulum membrane] (R-HSA-9913191) SGCA [Golgi membrane] (R-HSA-9913182) SGCA [plasma membrane] (R-HSA-9630720)	0.556	3
UniProt:P40227 CCT6A	1	CCT6A [cytosol] (R-HSA-390454)	0.556	3
UniProt:Q07869 PPARA	2	PPARA [nucleoplasm] (R-HSA-400186) monoSUMO1-K185-PPARA [nucleoplasm] (R-HSA-4341099)	0.556	3
UniProt:O43463 SUV39H1	1	SUV39H1 [nucleoplasm] (R-HSA-427517)	0.556	3
UniProt:P54252 ATXN3	2	ATXN3 [nucleoplasm] (R-HSA-6783285) ATXN3 [cytosol] (R-HSA-5625607)	0.556	3
UniProt:Q13200 PSMD2	5	PSMD2 [cytosol] (R-HSA-68796) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [secretory granule lumen] (R-HSA-6800919) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435)	0.556	3
UniProt:Q96E93 KLRG1	1	KLRG1 [plasma membrane] (R-HSA-198006)	0.556	3
UniProt:P21246 PTN	1	PTN [extracellular region] (R-HSA-201500)	0.556	3
UniProt:Q9NUD9 PIGV	1	PIGV [endoplasmic reticulum membrane] (R-HSA-162739)	0.556	3
UniProt:O60259 KLK8	3	proKLK8 [extracellular region] (R-HSA-8850832) KLK8 [extracellular region] (R-HSA-8850833) KLK8 propeptide [extracellular region] (R-HSA-8850829)	0.556	3
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.556	3
UniProt:Q8N448 LNX2			0.556	3
UniProt:Q9NPC7 MYNN			0.556	3
UniProt:P51674 GPM6A			0.556	3
UniProt:P25490 YY1	1	YY1 [nucleoplasm] (R-HSA-4086091)	0.556	3
IntAct:EBI-25833683 CCSB			0.556	3
UniProt:Q8TBJ4 PLPPR1	1	LPPR1 [plasma membrane] (R-HSA-6797625)	0.556	3
UniProt:Q13702-2 Q137022			0.556	3
UniProt:Q13428-5 TCOF1			0.556	3
UniProt:Q7Z614-3 SNX20			0.556	3
IntAct:EBI-25836632 CCSB			0.556	3
UniProt:P36894 BMPR1A	2	p-4S-BMPR1A [plasma membrane] (R-HSA-201448) BMPR1A [plasma membrane] (R-HSA-201480)	0.527	4
UniProt:P42338 PIK3CB	1	PIK3CB [cytosol] (R-HSA-74788)	0.527	3
UniProt:Q96S97 MYADM			0.527	4
UniProt:O00459 PIK3R2	3	PIK3R2 [cytosol] (R-HSA-74791) K63polyUb-PIK3R2 [cytosol] (R-HSA-3080554) p-Y464-PIK3R2 [cytosol] (R-HSA-9860512)	0.527	3
UniProt:Q7Z4F1 LRP10	1	LRP10 [plasma membrane] (R-HSA-2424275)	0.527	3
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.527	3
UniProt:Q9NZ56 FMN2			0.527	3
UniProt:Q8IWF6 DENND6A	1	DENND6A [cytosol] (R-HSA-8876587)	0.527	3
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.527	3
UniProt:Q13705 ACVR2B	1	ACVR2B [plasma membrane] (R-HSA-201656)	0.527	3
UniProt:Q9NRW1 RAB6B	6	RAB6B [endoplasmic reticulum membrane] (R-HSA-8849252) RAB6B [trans-Golgi network membrane] (R-HSA-6810985) RAB6B [Golgi membrane] (R-HSA-8849249) GGC-RAB6B [trans-Golgi network membrane] (R-HSA-8876081) GGC-RAB6B [cytosol] (R-HSA-8874055) RAB6B [cytosol] (R-HSA-6810983)	0.527	2
UniProt:P55082 MFAP3	1	MFAP3 [extracellular region] (R-HSA-2161382)	0.527	2
UniProt:Q969Z4 TR19L			0.527	2
UniProt:Q99741 CDC6	4	CDC6 [cytosol] (R-HSA-113566) p-CDC6 [cytosol] (R-HSA-68583) p-CDC6 [nucleoplasm] (R-HSA-5661317) CDC6 [nucleoplasm] (R-HSA-68542)	0.527	2
UniProt:Q6P5Z2 PKN3	2	p-T718-PKN3 [cytosol] (R-HSA-5623654) PKN3 [cytosol] (R-HSA-5623611)	0.527	3
UniProt:Q6PJF5 RHBDF2	2	iRHOM2 [Golgi lumen] (R-HSA-9673787) iRHOM2 [endoplasmic reticulum membrane] (R-HSA-9662859)	0.527	2
UniProt:P23458 JAK1	6	p-Y-JAK1 [cytosol] (R-HSA-451921) JAK1 [cytosol] (R-HSA-451898) p-Y1034-JAK1 [cytosol] (R-HSA-1112543) p-JAK1 [cytosol] (R-HSA-8950711) JAK1 [endosome] (R-HSA-8983168) p-Y1034,Y1035-JAK1 [cytosol] (R-HSA-9005335)	0.527	3
UniProt:Q16513 PKN2	2	PKN2 [cytosol] (R-HSA-5623612) p-T816-PKN2 [cytosol] (R-HSA-5623652)	0.527	3
UniProt:P07200	7	TGFB1 [platelet alpha granule lumen] (R-SSC-65936) TGFB1 [plasma membrane] (R-SSC-5146781) TGFB1 [Golgi lumen] (R-SSC-114705) TGFB1 [Golgi lumen] (R-SSC-177108) TGFB1 [Golgi lumen] (R-SSC-9736812) TGFB1 [extracellular region] (R-SSC-2395367) TGFB1 [extracellular region] (R-SSC-170838)	0.525	2
UniProt:Q93074 MED12	1	MED12 [nucleoplasm] (R-HSA-212343)	0.524	3
UniProt:Q9UER7 DAXX	13	DAXX [nucleoplasm] (R-HSA-3222068) DAXX A36Qfs108 [nucleoplasm] (R-HSA-9673105) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX S138 [nucleoplasm] (R-HSA-9673081) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.508	2
UniProt:A2AGH6 Med12	2	Med12 [nucleoplasm] (R-MMU-556777) Med12 [nucleoplasm] (R-MMU-212343)	0.471	3
UniProt:Q9BYF1 ACE2	5	glycosylated-ACE2 [plasma membrane] (R-HSA-9683480) ACE2 [endocytic vesicle membrane] (R-HSA-9698958) glycosylated-ACE2 [endocytic vesicle membrane] (R-HSA-9686721) ACE2 [endoplasmic reticulum lumen] (R-HSA-9683474) ACE2(18-805) [plasma membrane] (R-HSA-2022344)	0.463	2

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