Reactome | TP53 family members stimulate BAX transcription

TP53 family members stimulate BAX transcription

Stable Identifier

R-HSA-3700984

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 Regulates Transcription of Genes Involved in Cytochrome C Release (Homo sapiens)
        
        TP53 family members stimulate BAX transcription (Homo sapiens)

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TP53 family members stimulate BAX transcription

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BAX is a member of the group of pro-apoptotic proteins possessing the BH3 domain. These proteins undergo conformational activation leading to oligomerization and insertion in the outer mitochondrial membrane. This process is presumed to result in permeabilization of outer mitochondrial membrane and egress of apoptogenic factors, such as cytochrome C, that activate the caspase cascade leading to cellular demise. BAX gene transcription is stimulated by binding of TP53 (p53) (Miyashita and Reed 1995) or p53 family members TP63 (p63) and TP73 (p73) (Bergamaschi et al. 2004) to the p53 response element in the BAX gene promoter. ASSP proteins PPP1R13B (ASPP1) and TP53BP2 (ASPP2) form a complex with p53 family members and enhance transcription of the BAX gene (Samuels-Lev et al. 2001, Bergamaschi et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
11684014	ASPP proteins specifically stimulate the apoptotic function of p53 Hsieh, JK, Trigiante, G, Crook, T, Zhong, S, Bergamaschi, D, O'Connor, DJ, Lu, X, Campargue, I, Naumovski, L, Samuels-Lev, Y	Mol. Cell	2001
14729977	ASPP1 and ASPP2: common activators of p53 family members Samuels, Y, Lu, X, Jin, B, Duraisingham, S, Bergamaschi, D, Crook, T	Mol. Cell. Biol.	2004
7834749	Tumor suppressor p53 is a direct transcriptional activator of the human bax gene Miyashita, T, Reed, JC	Cell	1995