Reactome | Transcriptional Regulation by TP53

Transcriptional Regulation by TP53

Stable Identifier

R-HSA-3700989

DOI

10.3180/r-hsa-3700989.4

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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The tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many genes involved in a variety of cellular processes, such as cellular metabolism, survival, senescence, apoptosis and DNA damage response. Because of its critical function, p53 is frequently mutated in around 50% of all malignant tumors. For a recent review, please refer to Vousden and Prives 2009 and Kruiswijk et al. 2015.

Literature References

PubMed ID	Title	Journal	Year
26122615	p53 in survival, death and metabolic health: a lifeguard with a licence to kill Kruiswijk, F, Labuschagne, CF, Vousden, KH	Nat. Rev. Mol. Cell Biol.	2015
19410540	Blinded by the Light: The Growing Complexity of p53 Prives, C, Vousden, KH	Cell	2009