Reactome | CHD4 [nucleoplasm]

CHD4 [nucleoplasm]

Stable Identifier

R-HSA-3702078

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Chromodomain-helicase-DNA-binding protein 4, CHD4_HUMAN

Locations in the PathwayBrowser

Expand all

Chromatin organization (Homo sapiens)

- Chromatin modifying enzymes (Homo sapiens)
  - HDACs deacetylate histones (Homo sapiens)
    - HDAC1:2-containing complex binds HDAC2 Inhibitors (Homo sapiens)
      - HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        Mi-2 [nucleoplasm] (Homo sapiens)
        
        CHD4 [nucleoplasm] (Homo sapiens)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        Mi-2 [nucleoplasm] (Homo sapiens)
        
        CHD4 [nucleoplasm] (Homo sapiens)
    - HDAC1:2-containing complex deacetylate histones (Homo sapiens)
      - HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        Mi-2 [nucleoplasm] (Homo sapiens)
        
        CHD4 [nucleoplasm] (Homo sapiens)
      - HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        Mi-2 [nucleoplasm] (Homo sapiens)
        
        CHD4 [nucleoplasm] (Homo sapiens)

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - Potential therapeutics for SARS (Homo sapiens)
        
        HDAC1:2-containing complex binds HDAC2 Inhibitors (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        Mi-2 [nucleoplasm] (Homo sapiens)
        
        CHD4 [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
        
        HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
        
        NuRD complex [nucleoplasm] (Homo sapiens)
        
        Mi-2 [nucleoplasm] (Homo sapiens)
        
        CHD4 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q14839 CHD4

Gene Names

CHD4

Chain

chain:1-1912

Reference Genes

BioGPS Gene:1108 CHD4

COSMIC (genes):CHD4 CHD4

CTD Gene:1108 CHD4

dbSNP Gene:1108 CHD4

ENSEMBL:ENSG00000111642 CHD4

HGNC:1919 CHD4

KEGG:hsa:1108 CHD4

Monarch:1108 CHD4

NCBI Gene:1108 CHD4

OMIM:603277 CHD4

UCSC:Q14839 CHD4

Reference Transcript

Participates

as an input of

as a component of

as a member of

Mi-2 [nucleoplasm] (Homo sapiens)

Inferred To

Chd3 [nucleoplasm] (Drosophila melanogaster)

CHD4 [nucleoplasm] (Bos taurus)

CHD4 [nucleoplasm] (Canis familiaris)

CHD4 [nucleoplasm] (Gallus gallus)

CHD4 [nucleoplasm] (Sus scrofa)

Mi-2 [nucleoplasm] (Drosophila melanogaster)

chd4b [nucleoplasm] (Danio rerio)

let-418 [nucleoplasm] (Caenorhabditis elegans)

Chd4 [nucleoplasm] (Mus musculus)

Chd4 [nucleoplasm] (Rattus norvegicus)

chd-3 [nucleoplasm] (Caenorhabditis elegans)

mit1 [nucleoplasm] (Schizosaccharomyces pombe)

Homologues of CHD4 [nucleoplasm] (Caenorhabditis elegans)

Homologues of CHD4 [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_001284482.1, XP_006719021.1, NP_001264.2

OpenTargets

ENSG00000111642

ENSEMBL

ENST00000544040, ENSP00000440542, ENSP00000496634, ENSG00000111642, ENST00000645095

HPA

ENSG00000111642-CHD4

GeneCards

CHD4

PRO

Q14839

Pharos - Targets

Q14839

GlyGen

Q14839

Orphanet

CHD4

HMDB Protein

HMDBP11641

PDB

2L75, 2L5U, 8D4Y, 6RYU, 1MM3, 2EE1, 1MM2, 2N5N, 6Q3M, 6RYR, 6BGG, 4O9I

Interactors (28)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.93	16
UniProt:Q09028 RBBP4	1	RBBP4 [nucleoplasm] (R-HSA-212223)	0.837	9
UniProt:Q92769 HDAC2	2	HDAC2 [nucleoplasm] (R-HSA-205135) monoSUMO1-K462-HDAC2 [nucleoplasm] (R-HSA-4615958)	0.788	6
UniProt:P83916 CBX1	1	CBX1 [nucleoplasm] (R-HSA-9653629)	0.788	6
UniProt:Q13185 CBX3	1	CBX3 [nucleoplasm] (R-HSA-427386)	0.788	6
UniProt:O14519 CDKA1			0.725	5
UniProt:Q16576 RBBP7	1	RBBP7 [nucleoplasm] (R-HSA-212227)	0.677	8
UniProt:Q9BTC8 MTA3	1	MTA3 [nucleoplasm] (R-HSA-4657013)	0.643	4
UniProt:P19784 CSNK2A2	2	CSNK2A2 [cytosol] (R-HSA-201721) CSNK2A2 [nucleoplasm] (R-HSA-6805065)	0.643	3
UniProt:O94776 MTA2	1	MTA2 [nucleoplasm] (R-HSA-4657009)	0.63	6
UniProt:P51532 SMARCA4	1	SMARCA4 [nucleoplasm] (R-HSA-201686)	0.615	7
UniProt:O95983 MBD3	1	MBD3 [nucleoplasm] (R-HSA-4657010)	0.597	4
IntAct:EBI-15634422 H3K9-2			0.558	2
IntAct:EBI-15583943 H3(112)			0.558	2
UniProt:P45973 CBX5	2	CBX5 [nucleoplasm] (R-HSA-994093) monoSUMO1-K84,K-CBX5 [nucleoplasm] (R-HSA-4615849)	0.527	2
UniProt:P52294 KPNA1	2	KPNA1 [cytosol] (R-HSA-180612) KPNA1 [nucleoplasm] (R-HSA-188865)	0.527	2
UniProt:Q13330 MTA1	2	MTA1 [nucleoplasm] (R-HSA-3465550) polySUMO2,3-K509-MTA1 [nucleoplasm] (R-HSA-3465537)	0.527	3
UniProt:Q8WXI9 GATAD2B	1	GATAD2B [nucleoplasm] (R-HSA-3702079)	0.527	5
UniProt:Q96PV0 SYNGAP1	1	SYNGAP1 [cytosol] (R-HSA-5658217)	0.527	4
UniProt:Q86YP4 GATAD2A	1	GATAD2A [nucleoplasm] (R-HSA-3702077)	0.527	4
UniProt:Q93045 STMN2	1	STMN2 [cytosol] (R-HSA-9696513)	0.527	2
UniProt:P03129 VE7			0.527	2
UniProt:Q13257 MAD2L1	2	MAD2L1 [cytosol] (R-HSA-141400) Activated MAD2L1 [cytosol] (R-HSA-141447)	0.527	2
UniProt:Q9UHF7 TRPS1			0.527	2
UniProt:P68400 CSNK2A1	2	CSNK2A1 [cytosol] (R-HSA-201713) CSNK2A1 [nucleoplasm] (R-HSA-6805057)	0.527	2
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.499	2
UniProt:P70326 Tbx5	1	Tbx5 [nucleoplasm] (R-MMU-9734338)	0.499	3
UniProt:Q17R98 ZN827			0.499	2