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CHD4 [nucleoplasm]
Stable Identifier
R-HSA-3702078
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Chromodomain-helicase-DNA-binding protein 4, CHD4_HUMAN
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
HDACs deacetylate histones (Homo sapiens)
HDAC1:2-containing complex binds HDAC2 Inhibitors (Homo sapiens)
HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
HDAC1:2-containing complex deacetylate histones (Homo sapiens)
HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
Developmental Biology (Homo sapiens)
Adipogenesis (Homo sapiens)
Transcriptional regulation of brown and beige adipocyte differentiation (Homo sapiens)
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 (Homo sapiens)
CIDEA gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 and NuRD (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
DIO2 gene expression is stimulated by EBF2 and repressed by ZNF423 (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
PPARA gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 and NuRD (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:PPARA gene [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
UCP1 gene expression is stimulated by EBF2 and PPARG and repressed by ZNF423 and NuRD (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:UCP1 gene [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
ZNF423 recruits NuRD to EBF2 target genes (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
NuRD:ZNF423:EBF2,EBF2:Blnc1 lncRNA:HNRNPU:PPARA gene, UCP1 gene, (CIDEA gene, DIO2 gene) [nucleoplasm] (Homo sapiens)
NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:CIDEA gene [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:DIO2 gene [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:PPARA gene [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
NuRD:ZNF423:EBF2, EBF2:Blnc1 lncRNA:HNRNPU:UCP1 gene [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
Potential therapeutics for SARS (Homo sapiens)
HDAC1:2-containing complex binds HDAC2 Inhibitors (Homo sapiens)
HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
HDAC1:2-containing complex:HDAC2 inhibitors [nucleoplasm] (Homo sapiens)
HDAC1:2-containing complex [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Positive epigenetic regulation of rRNA expression (Homo sapiens)
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression (Homo sapiens)
Recruitment of ERCC6 (CSB), EHMT2 (G9a), and NuRD to the promoter of rRNA gene (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
TTF1:rRNA promoter:ERCC6:EHMT2 complex dimethylates histone H3 at lysine-9 (Homo sapiens)
TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
Regulation of endogenous retroelements (Homo sapiens)
Regulation of endogenous retroelements by KRAB-ZFP proteins (Homo sapiens)
NuRD complex binds SUMO2-6K-TRIM28:KRAB-ZNF:retroelement (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
NuRD:SUMO2-6K-TRIM28:KRAB-ZNF:retroelement chromatin [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) (Homo sapiens)
DNMT3A:DNMT3L in nascent RNA transcript:MeR-PIWIL4:2'-O-methyl-piRNA:SPOCD1:DNMT3A:DNMT3L methylates cytosine in DNA (Homo sapiens)
nascent LINE-1 RNA transcript:MeR-PIWIL4:2'-O-methyl-piRNA:SPOCD1:DNMT3A:DNMT3L [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
PIWIL4:piRNA binds nascent LINE1 pre-RNA and recruits SPOCD1, C19ORF84, DNMT3A, DNMT3L, the NURD complex, and the BAF complex (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
nascent LINE-1 RNA transcript:MeR-PIWIL4:2'-O-methyl-piRNA:SPOCD1:DNMT3A:DNMT3L [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
RNA Polymerase I Transcription (Homo sapiens)
RNA Polymerase I Promoter Clearance (Homo sapiens)
RNA Polymerase I Transcription Initiation (Homo sapiens)
Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter (Homo sapiens)
TTF-I:Sal Box:CSB:G9a:NuRD [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Acetylation (Homo sapiens)
MTA2-NuRD complex deacetylates TP53 (Homo sapiens)
MTA2-NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN gene transcription (Homo sapiens)
PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN (Homo sapiens)
SALL4:NuRD [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
SALL4:NuRD:PTEN gene [nucleoplasm] (Homo sapiens)
SALL4:NuRD [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
SALL4 recruits NuRD to PTEN gene (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
SALL4:NuRD:PTEN gene [nucleoplasm] (Homo sapiens)
SALL4:NuRD [nucleoplasm] (Homo sapiens)
NuRD complex [nucleoplasm] (Homo sapiens)
Mi-2 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
NGF-stimulated transcription (Homo sapiens)
EGR2:NAB2 and CHD4 bind the ID2 and ID4 promoter regions (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
ID2,ID4 gene:EGR2:NAB2:CHD4 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
Expression of ID2 and ID4 is repressed by EGR2:NAB (Homo sapiens)
ID2,ID4 gene:EGR2:NAB2:CHD4 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
RRAD gene:EGR2:NAB2:CHD4 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
RRAD gene expression (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
RRAD gene:EGR2:NAB2:CHD4 [nucleoplasm] (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14839 CHD4
Gene Names
CHD4
Chain
chain:1-1912
Reference Genes
COSMIC (genes):CHD4 CHD4
dbSNP Gene:1108 CHD4
ENSEMBL:ENSG00000111642 CHD4
Participates
as an input of
EGR2:NAB2 and CHD4 bind the ID2 and ID4 promoter regions (Homo sapiens)
NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Homo sapiens)
as a component of
ID2,ID4 gene:EGR2:NAB2:CHD4 [nucleoplasm] (Homo sapiens)
RRAD gene:EGR2:NAB2:CHD4 [nucleoplasm] (Homo sapiens)
as a member of
Mi-2 [nucleoplasm] (Homo sapiens)
Inferred To
CHD4 [nucleoplasm]
(Bos taurus)
CHD4 [nucleoplasm]
(Caenorhabditis elegans)
CHD4 [nucleoplasm]
(Canis familiaris)
CHD4 [nucleoplasm]
(Drosophila melanogaster)
CHD4 [nucleoplasm]
(Gallus gallus)
CHD4 [nucleoplasm]
(Mus musculus)
CHD4 [nucleoplasm]
(Schizosaccharomyces pombe)
CHD4 [nucleoplasm]
(Sus scrofa)
chd4b [nucleoplasm]
(Danio rerio)
Chd4 [nucleoplasm]
(Rattus norvegicus)
Homologues of CHD4 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of CHD4 [nucleoplasm]
(Drosophila melanogaster)
Interactors (24)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.924
15
UniProt:Q13185 CBX3
1
CBX3 [nucleoplasm]
(R-HSA-427386)
0.788
6
UniProt:Q92769 HDAC2
2
HDAC2 [nucleoplasm]
(R-HSA-205135)
monoSUMO1-K462-HDAC2 [nucleoplasm]
(R-HSA-4615958)
0.788
6
UniProt:Q09028 RBBP4
1
RBBP4 [nucleoplasm]
(R-HSA-212223)
0.788
8
UniProt:P83916 CBX1
1
CBX1 [nucleoplasm]
(R-HSA-9653629)
0.788
6
UniProt:Q9BTC8 MTA3
1
MTA3 [nucleoplasm]
(R-HSA-4657013)
0.643
4
UniProt:O14519 CDKA1
0.643
4
UniProt:O94776 MTA2
1
MTA2 [nucleoplasm]
(R-HSA-4657009)
0.63
6
UniProt:O95983 MBD3
1
MBD3 [nucleoplasm]
(R-HSA-4657010)
0.597
4
UniProt:Q16576 RBBP7
1
RBBP7 [nucleoplasm]
(R-HSA-212227)
0.577
7
IntAct:EBI-15583943 H3(112)
0.558
2
IntAct:EBI-15634422 H3K9-2
0.558
2
UniProt:P68400 CSNK2A1
2
CSNK2A1 [cytosol]
(R-HSA-201713)
CSNK2A1 [nucleoplasm]
(R-HSA-6805057)
0.527
2
UniProt:Q86YP4 GATAD2A
1
GATAD2A [nucleoplasm]
(R-HSA-3702077)
0.527
4
UniProt:Q96PV0 SYNGAP1
1
SYNGAP1 [cytosol]
(R-HSA-5658217)
0.527
4
UniProt:Q8WXI9 GATAD2B
1
GATAD2B [nucleoplasm]
(R-HSA-3702079)
0.527
5
UniProt:P51532 SMARCA4
1
SMARCA4 [nucleoplasm]
(R-HSA-201686)
0.527
3
UniProt:P19784 CSNK2A2
2
CSNK2A2 [cytosol]
(R-HSA-201721)
CSNK2A2 [nucleoplasm]
(R-HSA-6805065)
0.527
2
UniProt:Q13330 MTA1
2
MTA1 [nucleoplasm]
(R-HSA-3465550)
polySUMO2,3-K509-MTA1 [nucleoplasm]
(R-HSA-3465537)
0.527
3
UniProt:P03129 VE7
0.527
2
UniProt:P45973 CBX5
2
CBX5 [nucleoplasm]
(R-HSA-994093)
monoSUMO1-K84,K-CBX5 [nucleoplasm]
(R-HSA-4615849)
0.527
2
UniProt:Q17R98 ZN827
0.499
2
UniProt:P01106 MYC
2
MYC [nucleoplasm]
(R-HSA-188379)
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
0.499
2
UniProt:P70326 Tbx5
1
Tbx5 [nucleoplasm]
(R-MMU-9734338)
0.499
3
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