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CHD4 [nucleoplasm]
Stable Identifier
R-HSA-3702078
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Chromodomain-helicase-DNA-binding protein 4, CHD4_HUMAN
Locations in the PathwayBrowser for interactor UniProt:P83916 CBX1
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
NGF-stimulated transcription (Homo sapiens)
EGR2:NAB2 and CHD4 bind the ID2 and ID4 promoter regions (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Homo sapiens)
CHD4 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14839 CHD4
Gene Names
CHD4
Chain
chain:1-1912
Reference Genes
BioGPS Gene:1108 CHD4
COSMIC (genes):CHD4 CHD4
CTD Gene:1108 CHD4
dbSNP Gene:1108 CHD4
ENSEMBL:ENSG00000111642 CHD4
HGNC:1919 CHD4
KEGG Gene (Homo sapiens):1108 CHD4
Monarch:1108 CHD4
NCBI Gene:1108 CHD4
OMIM:603277 CHD4
UCSC:Q14839 CHD4
Reference Transcript
RefSeq:NM_001297553.1 CHD4
RefSeq:NM_001273.3 CHD4
RefSeq:XM_006718958.1 CHD4
Other Identifiers
0002260161
1108
11743463_a_at
11743464_a_at
11748943_a_at
16760465
201182_PM_s_at
201182_s_at
201183_PM_s_at
201183_s_at
201184_PM_s_at
201184_s_at
2394535
2394544
3442053
3442055
3442056
3442059
3442062
3442064
3442066
3442068
3442071
3442072
3442074
3442076
3442077
3442078
3442079
3442080
3442081
3442082
3442085
3442087
3442088
3442090
3442091
3442092
3442094
3442095
3442096
3442097
3442098
3442099
3442100
3442101
3442102
3442103
3442104
3442106
3442108
3442109
3442110
3442112
3442113
3442114
3442115
3442116
3442117
3442118
3442120
3442121
3442122
3442123
3442125
36137_at
7960594
A_23_P53541
GE60108
GO:0000166
GO:0000781
GO:0000785
GO:0001221
GO:0003674
GO:0003677
GO:0003678
GO:0004386
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005813
GO:0005815
GO:0005856
GO:0006325
GO:0006338
GO:0006464
GO:0008134
GO:0008150
GO:0008270
GO:0009058
GO:0010629
GO:0016020
GO:0016575
GO:0016581
GO:0016787
GO:0016887
GO:0019899
GO:0030154
GO:0031492
GO:0032508
GO:0032991
GO:0034641
GO:0042659
GO:0042826
GO:0043167
GO:0043226
GO:0045892
GO:0045893
GO:0046872
GO:0051276
GO:0061629
GO:0090575
GO:0140657
GO:0140658
GO:2000736
HMNXSV003055362
Hs.74441.0.S1_3p_a_at
Hs.74441.0.S2_3p_a_at
ILMN_1658411
ILMN_1685551
PH_hs_0004247
PH_hs_0031309
TC12001143.hg
X86691_at
g4557452_3p_a_at
Participates
as an input of
EGR2:NAB2 and CHD4 bind the ID2 and ID4 promoter regions (Homo sapiens)
NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (Homo sapiens)
as a component of
ID2,ID4 gene:EGR2:NAB2:CHD4 [nucleoplasm] (Homo sapiens)
RRAD gene:EGR2:NAB2:CHD4 [nucleoplasm] (Homo sapiens)
as a member of
Mi-2 [nucleoplasm] (Homo sapiens)
Inferred To
Chd3 [nucleoplasm]
(Drosophila melanogaster)
CHD4 [nucleoplasm]
(Bos taurus)
CHD4 [nucleoplasm]
(Canis familiaris)
CHD4 [nucleoplasm]
(Gallus gallus)
CHD4 [nucleoplasm]
(Sus scrofa)
chd4a [nucleoplasm]
(Danio rerio)
Mi-2 [nucleoplasm]
(Drosophila melanogaster)
chd4 [nucleoplasm]
(Xenopus tropicalis)
chd4b [nucleoplasm]
(Danio rerio)
let-418 [nucleoplasm]
(Caenorhabditis elegans)
Chd4 [nucleoplasm]
(Mus musculus)
Chd4 [nucleoplasm]
(Rattus norvegicus)
chd-3 [nucleoplasm]
(Caenorhabditis elegans)
mit1 [nucleoplasm]
(Schizosaccharomyces pombe)
Homologues of CHD4 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of CHD4 [nucleoplasm]
(Danio rerio)
Homologues of CHD4 [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001284482.1
,
NP_001264.2
,
XP_006719021.1
OpenTargets
ENSG00000111642
IntEnz
3.6.4.12
HPA
ENSG00000111642-CHD4
GeneCards
Q14839
Ensembl
ENST00000645095
,
ENSG00000111642
,
ENSP00000440542
,
ENSP00000496634
,
ENST00000544040
PRO
Q14839
Pharos - Targets
Q14839
Orphanet
24413
HMDB Protein
HMDBP11641
PDB
2EE1
,
6Q3M
,
6RYU
,
1MM3
,
2L75
,
1MM2
,
2N5N
,
6BGG
,
2L5U
,
6RYR
,
4O9I
Interactors (17)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.885
11
UniProt:Q92769 HDAC2
2
monoSUMO1-K462-HDAC2 [nucleoplasm]
(R-HSA-4615958)
HDAC2 [nucleoplasm]
(R-HSA-205135)
0.725
5
UniProt:P83916 CBX1
1
CBX1 [nucleoplasm]
(R-HSA-9653629)
0.725
5
UniProt:Q13185 CBX3
1
CBX3 [nucleoplasm]
(R-HSA-427386)
0.725
5
UniProt:Q9BTC8 MTA3
1
MTA3 [nucleoplasm]
(R-HSA-4657013)
0.643
4
UniProt:Q09028 RBBP4
1
RBBP4 [nucleoplasm]
(R-HSA-212223)
0.643
4
UniProt:O94776 MTA2
1
MTA2 [nucleoplasm]
(R-HSA-4657009)
0.63
6
UniProt:O95983 MBD3
1
MBD3 [nucleoplasm]
(R-HSA-4657010)
0.597
4
IntAct:EBI-15583943 H3(112)
0.558
2
IntAct:EBI-15634422 H3K9-2
0.558
2
UniProt:P45973 CBX5
2
CBX5 [nucleoplasm]
(R-HSA-994093)
monoSUMO1-K84,K-CBX5 [nucleoplasm]
(R-HSA-4615849)
0.527
2
UniProt:Q13330 MTA1
2
MTA1 [nucleoplasm]
(R-HSA-3465550)
polySUMO2,3-K509-MTA1 [nucleoplasm]
(R-HSA-3465537)
0.527
3
UniProt:P03129 VE7
0.527
2
UniProt:O14519 CDKA1
0.527
2
UniProt:Q17R98 ZN827
0.499
2
UniProt:P70326
1
Tbx5 [nucleoplasm]
(R-MMU-2032786)
0.499
3
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.499
2
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