phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix]

Stable Identifier
Reaction [transition]
Homo sapiens
Exchange of cytosolic citrate for mitochondrial phosphoenolpyruvate
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SLC25A1, in the inner mitochondrial membrane, mediates the exchange of cytosolic citrate for mitochondrial phosphoenolpyruvate. The exchange is physiologically irreversible because of the potential of the inner mitochondrial membrane. The gene encoding human SLC25A1 has been cloned and its expression pattern has been characterized (Heisterkamp et al. 1995; Iacobazzi et al. 1997), but the biochemical details of the transport process are inferred from those worked out for the well-characterized rat system (Robinson 1971; Soling et al. 1971; Kleineke et al. 1973).

Literature References
PubMed ID Title Journal Year
8666394 Localization of the human mitochondrial citrate transporter protein gene to chromosome 22Q11 in the DiGeorge syndrome critical region

Heisterkamp, N, Mulder, MP, Langeveld, A, ten Hoeve, J, Wang, Z, Roe, BA, Groffen, J

Genomics 1995
9254007 Organization and sequence of the human gene for the mitochondrial citrate transport protein

Iacobazzi, V, Lauria, G, Palmieri, F

DNA Seq 1997
Catalyst Activity

tricarboxylic acid transmembrane transporter activity of SLC25A1 [mitochondrial inner membrane]

Orthologous Events
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