Reactome | SLC25A12 [mitochondrial inner membrane]

SLC25A12 [mitochondrial inner membrane]

Stable Identifier

R-HSA-372470

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

ARALAR1

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- Aerobic respiration and respiratory electron transport (Homo sapiens)
  - Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Homo sapiens)
    - Respiratory electron transport (Homo sapiens)
      - Malate-aspartate shuttle (Homo sapiens)
        
        SLC25A12,13 exchange L-Glu and L-Asp (Homo sapiens)
        
        SLC25A12,13 [mitochondrial inner membrane] (Homo sapiens)
        
        SLC25A12:Ca2+ [mitochondrial inner membrane] (Homo sapiens)
        
        SLC25A12 [mitochondrial inner membrane] (Homo sapiens)
- Metabolism of amino acids and derivatives (Homo sapiens)
  - Aspartate and asparagine metabolism (Homo sapiens)
    - SLC25A12,13 exchange L-Glu and L-Asp (Homo sapiens)
      - SLC25A12,13 [mitochondrial inner membrane] (Homo sapiens)
        
        SLC25A12:Ca2+ [mitochondrial inner membrane] (Homo sapiens)
        
        SLC25A12 [mitochondrial inner membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O75746 SLC25A12

Gene Names

SLC25A12, AGC1, ARALAR1

Chain

initiator methionine:, chain:2-678

Reference Genes

BioGPS Gene:8604 SLC25A12

COSMIC (genes):SLC25A12 SLC25A12

CTD Gene:8604 SLC25A12

dbSNP Gene:8604 SLC25A12

ENSEMBL:ENSG00000115840 SLC25A12

ENSEMBL_homo_sapiens_GENE:ENSG00000115840.14 SLC25A12

ENSEMBL_homo_sapiens_GENE:ENSG00000292099.1 SLC25A12

HGNC:10982 SLC25A12

KEGG Gene (Homo sapiens):8604 SLC25A12

Monarch:8604 SLC25A12

NCBI Gene:8604 SLC25A12

OMIM:603667 SLC25A12

UCSC:O75746 SLC25A12

Reference Transcript

RefSeq:NM_003705.4 SLC25A12

Other Identifiers

11733791_at

11733792_a_at

11749348_a_at

16905076

203339_PM_at

203339_at

203340_PM_s_at

203340_s_at

2586842

2586844

2586846

2586847

2586848

2586849

2586850

2586851

2586852

2586855

2586856

2586861

2586862

2586866

2586868

2586871

2586873

2586874

2586878

2586880

2586884

2586885

2586886

2586888

2586894

2586895

2586901

3240921

33256_at

80142_at

8056766

8604

A_23_P142714

A_24_P405313

GE490134

GE60318

GO:0000514

GO:0000515

GO:0005215

GO:0005313

GO:0005509

GO:0005515

GO:0005739

GO:0005743

GO:0005975

GO:0006091

GO:0006094

GO:0006520

GO:0008514

GO:0009066

GO:0015172

GO:0015183

GO:0015297

GO:0015804

GO:0015810

GO:0015813

GO:0016020

GO:0042802

GO:0043226

GO:0043490

GO:0046872

GO:0051592

GO:0055085

GO:0070778

GO:0071705

GO:0072337

GO:1902600

HMNXSV003027762

Hs.179866.0.S2_3p_at

ILMN_1788053

PH_hs_0023961

TC02002523.hg

g4507006_3p_a_at

Participates

as a component of

SLC25A12:Ca2+ [mitochondrial inner membrane] (Homo sapiens)

Other forms of this molecule

SLC25A12 [mitochondrial intermembrane space]

Inferred To

AGC1 [mitochondrial inner membrane] (Saccharomyces cerevisiae)

cb1094 [mitochondrial inner membrane] (Danio rerio)

SLC25A12 [mitochondrial inner membrane] (Bos taurus)

SLC25A12 [mitochondrial inner membrane] (Caenorhabditis elegans)

SLC25A12 [mitochondrial inner membrane] (Canis familiaris)

SLC25A12 [mitochondrial inner membrane] (Dictyostelium discoideum)

SLC25A12 [mitochondrial inner membrane] (Drosophila melanogaster)

SLC25A12 [mitochondrial inner membrane] (Gallus gallus)

SLC25A12 [mitochondrial inner membrane] (Mus musculus)

SLC25A12 [mitochondrial inner membrane] (Rattus norvegicus)

SLC25A12 [mitochondrial inner membrane] (Sus scrofa)

slc25a12 [mitochondrial inner membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_003696.2

Guide to Pharmacology - Targets

1054

OpenTargets

ENSG00000115840

GeneCards

O75746

HPA

ENSG00000115840-SLC25A12

Ensembl

ENSG00000115840, ENSP00000388658, ENST00000422440

PRO

O75746

Pharos - Targets

O75746

Orphanet

22182

HMDB Protein

HMDBP03143

PDB

4P60, 4P5X

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.537	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	10

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