Reactome | SLC25A12 [mitochondrial inner membrane]

SLC25A12 [mitochondrial inner membrane]

Stable Identifier

R-HSA-372470

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

ARALAR1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O75746 SLC25A12

Gene Names

SLC25A12, AGC1, ARALAR1

Chain

initiator methionine:, chain:2-678

Reference Genes

BioGPS Gene:8604 SLC25A12

COSMIC (genes):SLC25A12 SLC25A12

CTD Gene:8604 SLC25A12

dbSNP Gene:8604 SLC25A12

ENSEMBL:ENSG00000115840 SLC25A12

HGNC:10982 SLC25A12

KEGG:hsa:8604 SLC25A12

Monarch:8604 SLC25A12

NCBI Gene:8604 SLC25A12

OMIM:603667 SLC25A12

UCSC:O75746 SLC25A12

Reference Transcript

RefSeq:NM_003705.4 SLC25A12

Other Identifiers

11733791_at

11733792_a_at

11749348_a_at

16905076

203339_PM_at

203339_at

203340_PM_s_at

203340_s_at

2586842

2586844

2586846

2586847

2586848

2586849

2586850

2586851

2586852

2586855

2586856

2586857

2586858

2586859

2586861

2586862

2586865

2586866

2586868

2586871

2586872

2586873

2586874

2586878

2586880

2586881

2586882

2586883

2586884

2586885

2586886

2586887

2586888

2586891

2586894

2586895

2586901

3240921

33256_at

80142_at

8056766

8604

A_23_P142714

A_24_P405313

GE490134

GE60318

GO:0000514

GO:0000515

GO:0005215

GO:0005313

GO:0005509

GO:0005515

GO:0005739

GO:0005743

GO:0006851

GO:0008514

GO:0015172

GO:0015183

GO:0015297

GO:0015804

GO:0015810

GO:0015813

GO:0016020

GO:0042802

GO:0043226

GO:0043490

GO:0046872

GO:0051592

GO:0055085

GO:0070778

GO:1902600

HMNXSV003027762

Hs.179866.0.S2_3p_at

ILMN_1788053

PH_hs_0023961

TC02002523.hg

g4507006_3p_a_at

Participates

as a component of

SLC25A12:Ca2+ [mitochondrial inner membrane] (Homo sapiens)

Other forms of this molecule

SLC25A12 [mitochondrial intermembrane space]

Inferred To

AGC1 [mitochondrial inner membrane] (Saccharomyces cerevisiae)

SLC25A12 [mitochondrial inner membrane] (Bos taurus)

SLC25A12 [mitochondrial inner membrane] (Caenorhabditis elegans)

SLC25A12 [mitochondrial inner membrane] (Canis familiaris)

SLC25A12 [mitochondrial inner membrane] (Dictyostelium discoideum)

SLC25A12 [mitochondrial inner membrane] (Drosophila melanogaster)

SLC25A12 [mitochondrial inner membrane] (Gallus gallus)

SLC25A12 [mitochondrial inner membrane] (Mus musculus)

SLC25A12 [mitochondrial inner membrane] (Rattus norvegicus)

SLC25A12 [mitochondrial inner membrane] (Sus scrofa)

slc25a12 [mitochondrial inner membrane] (Danio rerio)

slc25a12 [mitochondrial inner membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_003696.2

Guide to Pharmacology - Targets

1054

ENSEMBL

ENST00000709717, ENSP00000388658, ENSP00000517838, ENST00000422440, ENSG00000292099, ENSG00000115840

OpenTargets

ENSG00000115840

GeneCards

SLC25A12

HPA

ENSG00000115840-SLC25A12

PRO

O75746

Pharos - Targets

O75746

GlyGen

O75746

Orphanet

SLC25A12

HMDB Protein

HMDBP03143

PDB

4P60, 4P5X

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.537	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	10

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