Reactome | p-Y-BCAR1 [cytosol]

p-Y-BCAR1 [cytosol]

Stable Identifier

R-HSA-372645

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phosphorylated p130Cas

Locations in the PathwayBrowser

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Hemostasis (Homo sapiens)

- Platelet activation, signaling and aggregation (Homo sapiens)
  - Platelet Aggregation (Plug Formation) (Homo sapiens)
    - Integrin signaling (Homo sapiens)
      - p130Cas linkage to MAPK signaling for integrins (Homo sapiens)
        
        Crk binding to p130cas (Homo sapiens)
        
        CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        p-Y-BCAR1 [cytosol] (Homo sapiens)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        p-Y-BCAR1 [cytosol] (Homo sapiens)
        
        Phosphorylation of BCAR1 by SRC-PTK2 complex (Homo sapiens)
        
        p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)
        
        p-Y-BCAR1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P56945 BCAR1

Gene Names

BCAR1, CAS, CASS1, CRKAS

Chain

chain:1-870

Reference Genes

BioGPS Gene:9564 BCAR1

COSMIC (genes):BCAR1 BCAR1

CTD Gene:9564 BCAR1

dbSNP Gene:9564 BCAR1

ENSEMBL:ENSG00000050820 BCAR1

HGNC:971 BCAR1

KEGG:hsa:9564 BCAR1

Monarch:9564 BCAR1

NCBI Gene:9564 BCAR1

OMIM:602941 BCAR1

UCSC:P56945 BCAR1

Reference Transcript

Other Identifiers

11720126_x_at

11747862_x_at

11748644_x_at

11749654_x_at

11750641_x_at

16828427

223116_PM_at

223116_at

3612289

3612290

3612292

3612923

3612924

3612927

3699423

3699425

3699427

3699428

3699429

3699430

3699433

3699434

3699435

3699436

3699437

3699438

3699439

3699441

3699442

3699443

3699444

3699445

3699446

3699449

3699450

3699451

3699452

3699453

3699462

3699466

3699468

3699469

3699470

3699471

3699488

3699489

3699490

3699491

3699492

3699493

65885_at

8002854

9564

A_23_P66319

A_33_P3369034

GE61124

GE837016

GE861779

GO:0001558

GO:0001726

GO:0002376

GO:0005515

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0005925

GO:0007015

GO:0007155

GO:0007169

GO:0007173

GO:0007186

GO:0007229

GO:0008286

GO:0010595

GO:0015629

GO:0016020

GO:0016477

GO:0017124

GO:0019901

GO:0030027

GO:0030335

GO:0030424

GO:0035729

GO:0042981

GO:0042995

GO:0043226

GO:0048008

GO:0048010

GO:0048011

GO:0048012

GO:0048870

GO:0050851

GO:0050852

GO:0050853

GO:0051301

GO:0060326

GO:0070161

GO:0086100

HMNXSV003008909

ILMN_1672596

PH_hs_0014101

g6740101_3p_at

Participates

as a component of

p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Homo sapiens)

Other forms of this molecule

BCAR1 [cytosol]

p-Y165,Y664-BCAR1 [cytosol]

p-Y12-BCAR1 [cytosol]

Inferred To

phospho-Bcar1 [cytosol] (Mus musculus)

phospho-Bcar1 [cytosol] (Rattus norvegicus)

phospho-BCAR1 [cytosol] (Bos taurus)

phospho-BCAR1 [cytosol] (Canis familiaris)

phospho-BCAR1 [cytosol] (Sus scrofa)

phospho-p-Y-BCAR1 [cytosol] (Gallus gallus)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_055382.2, NP_001164186.1, NP_001164187.1, NP_001164188.1, XP_016879386.1, NP_001164190.1, NP_001164191.1, NP_001164189.1, NP_001164185.1

OpenTargets

ENSG00000050820

ENSEMBL

ENSP00000392708, ENSP00000440370, ENSP00000377072, ENST00000393422, ENSP00000377074, ENST00000393420, ENST00000418647, ENST00000535626, ENST00000162330, ENST00000542031, ENST00000538440, ENSP00000162330, ENSP00000440415, ENST00000420641, ENSP00000443841, ENSP00000391669

HPA

ENSG00000050820-BCAR1

PRO

P56945

Pharos - Targets

P56945

PDB

1WYX, 3T6G, 5O2M, 5O2P, 5O2Q

Interactors (34)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.816	7
UniProt:P18031 PTPN1	2	PTPN1 [endosome membrane] (R-HSA-9815895) PTPN1 [cytosol] (R-HSA-210625)	0.786	5
UniProt:P06241 FYN	6	FYN [cytosol] (R-HSA-200917) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y531-FYN [cytosol] (R-HSA-391819) p-S21,Y420-FYN [cytosol] (R-HSA-5218745)	0.716	4
UniProt:Q8N5H7-2 SH2D3C			0.693	8
UniProt:Q05209 PTPN12	2	PTPN12 [cytosol] (R-HSA-432933) PTPN12 [nucleoplasm] (R-HSA-9008905)	0.691	5
UniProt:P12931 SRC	6	MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-SRC [plasma membrane] (R-HSA-8876922) p-Y419-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690)	0.688	3
UniProt:O75815 BCAR3			0.643	4
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.615	4
UniProt:O75815-1 BCAR3			0.611	3
UniProt:Q05397 PTK2	11	p-6Y-PTK2 [cytosol] (R-HSA-354128) p-Y397-PTK2 [cytosol] (R-HSA-354068) PTK2 [cytosol] (R-HSA-201621) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2(773-1052) [cytosol] (R-HSA-202829) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) pY-PTK2 [cytosol] (R-HSA-9632393) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613)	0.589	2
UniProt:P46940 IQGAP1	3	IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [plasma membrane] (R-HSA-381681)	0.576	4
UniProt:O75604 USP2	2	USP2 [cytosol] (R-HSA-5212661) USP2 [nucleoplasm] (R-HSA-5689946)	0.556	3
UniProt:Q9BZE0 GLIS2			0.556	3
UniProt:P06241-3 FYN			0.556	3
UniProt:P53618 COPB1	8	COPB1 [endoplasmic reticulum membrane] (R-HSA-6810955) COPB1 [Golgi membrane] (R-HSA-6808735) COPB1 [transport vesicle] (R-HSA-6808736) COPB1 [cytosol] (R-HSA-199995) COPB1 [tertiary granule membrane] (R-HSA-6800175) COPB1 [secretory granule membrane] (R-HSA-6800914) COPB1 [plasma membrane] (R-HSA-6806431) COPB1 [ficolin-1-rich granule membrane] (R-HSA-6800972)	0.556	3
UniProt:Q86YD7 F90A1			0.556	3
UniProt:Q96QH2 PRAM			0.556	3
UniProt:Q49AR9 Q49AR9			0.556	3
UniProt:P07947 YES1	2	MyrG-p-Y426-YES1 [plasma membrane] (R-HSA-1810411) YES1 [cytosol] (R-HSA-373640)	0.556	3
UniProt:Q5T9C2-3 EEIG1			0.556	3
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.556	3
UniProt:P18206-2 VCL			0.556	3
UniProt:Q68CZ2 TNS3	1	TNS3 [cytosol] (R-HSA-8875524)	0.556	8
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.536	2
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.527	5
UniProt:Q07912 TNK2	1	TNK2 [cytosol] (R-HSA-9842568)	0.524	5
UniProt:Q04205 TENS1			0.524	2
UniProt:Q9H792 PEAK1	1	PEAK1 [cytosol] (R-HSA-9715162)	0.499	3
UniProt:Q9QWI6 SRCN1			0.499	3
UniProt:Q8N5H7 SH2D3			0.499	2
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.483	3
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.483	3
UniProt:Q9C0H9 SRCN1			0.463	3
UniProt:P50281 MMP14	4	MMP14 [plasma membrane] (R-HSA-1442472) MMP14(21-582) [Golgi lumen] (R-HSA-1604689) MMP14 [Golgi lumen] (R-HSA-1604724) MMP14 [Golgi membrane] (R-HSA-9858808)	0.463	3

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