Reactome | Phosphorylation of BCAR1 by SRC-PTK2 complex

Phosphorylation of BCAR1 by SRC-PTK2 complex

Stable Identifier

R-HSA-372693

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Phosphorylation of BCAR1 by SRC-PTK2 complex

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SH3-mediated binding of BCAR1/p130Cas to PTK2 is linked to enhanced tyrosine phosphorylation of BCAR1 at multiple sites. The Cas substrate domain contains 15 separate YxxP motifs, a main site of tyrosine phosphorylation on the BCAR1 molecule. Once phosphorylated, this domain serves as a docking site for the SH2 domains of CRK or NCK adaptor proteins that affect the downstream MAPK signalling pathway, resulting in cell survival and increased motility.

Literature References

PubMed ID	Title	Journal	Year
8621540	Direct binding of C-terminal region of p130Cas to SH2 and SH3 domains of Src kinase Yazaki, Y, Sakai, R, Ozawa, K, Hirai, H, Nakamoto, T	J. Biol. Chem.	1996
16581250	p130Cas: a versatile scaffold in signaling networks Defilippi, P, Di Stefano, P, Cabodi, S	Trends Cell Biol	2006
12585966	Bidirectional integrin alphaIIbbeta3 signalling regulating platelet adhesion under flow: contribution of protein kinase C Giuliano, S, Jackson, SP, Rooney, M, Nesbitt, WS	Biochem J	2003
12640026	Focal adhesion kinase: the first ten years Parsons, JT	J Cell Sci	2003