BCAR1 (breast cancer anti-estrogen resistance protein1, also known as Crk-associated substrate (Cas) or p130Cas) is an adaptor protein that promotes protein-protein interactions, leading to the multiprotein complexes. The interaction of ?BCAR1/p130Cas with other proteins modulates cell motility, survial and proliferation. BCAR1/P130Cas is one of the main phosphorylation targets of the PTK2/SRC complex. The BCAR1 SH3 domain binds to PR1 and PR2 (‘PxxP’) domains in the PTK2 C-terminal domain.
Vuori, K, Hirai, H, Aizawa, S, Ruoslahti, E
Defilippi, P, Di Stefano, P, Cabodi, S
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