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p130Cas linkage to MAPK signaling for integrins
Stable Identifier
R-HSA-372708
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Platelet Aggregation (Plug Formation) (Homo sapiens)
Integrin signaling (Homo sapiens)
p130Cas linkage to MAPK signaling for integrins (Homo sapiens)
Signal Transduction (Homo sapiens)
Integrin signaling (Homo sapiens)
p130Cas linkage to MAPK signaling for integrins (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
|
PDF
SVG
|
PNG
Low
Medium
High
|
PPTX
|
SBGN
Click the image above or
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Integrin signaling is linked to the MAP kinase pathway by recruiting p130cas and Crk to the FAK/Src activation complex.
Literature References
PubMed ID
Title
Journal
Year
16581250
p130Cas: a versatile scaffold in signaling networks
Defilippi, P
,
Di Stefano, P
,
Cabodi, S
Trends Cell Biol
2006
Participants
Events
Recruitment of BCAR1 to PTK2 complex
(Homo sapiens)
Phosphorylation of BCAR1 by SRC-PTK2 complex
(Homo sapiens)
Crk binding to p130cas
(Homo sapiens)
Participates
as an event of
Integrin signaling (Homo sapiens)
Orthologous Events
p130Cas linkage to MAPK signaling for integrins (Bos taurus)
p130Cas linkage to MAPK signaling for integrins (Canis familiaris)
p130Cas linkage to MAPK signaling for integrins (Gallus gallus)
p130Cas linkage to MAPK signaling for integrins (Mus musculus)
p130Cas linkage to MAPK signaling for integrins (Rattus norvegicus)
p130Cas linkage to MAPK signaling for integrins (Sus scrofa)
Cross References
BioModels Database
BIOMD0000000466
,
BIOMD0000000340
,
BIOMD0000000468
,
BIOMD0000000339
,
BIOMD0000000338
Authored
Garapati, P V (2008-06-16)
Reviewed
Shattil, SJ (2008-09-16)
Created
Garapati, P V (2008-06-27)
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