Reactome | PCK2 [mitochondrial matrix]

PCK2 [mitochondrial matrix]

Stable Identifier

R-HSA-372815

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Phosphoenolpyruvate carboxykinase (GTP), mitochondrial

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q16822 PCK2

Gene Names

PCK2, PEPCK2

Chain

transit peptide:1-32, chain:33-640

Reference Genes

BioGPS Gene:5106 PCK2

COSMIC (genes):PCK2 PCK2

CTD Gene:5106 PCK2

dbSNP Gene:5106 PCK2

ENSEMBL:ENSG00000100889 PCK2

ENSEMBL_homo_sapiens_GENE:ENSG00000100889.12 PCK2

ENSEMBL_homo_sapiens_GENE:ENSG00000285241.2 PCK2

HGNC:8725 PCK2

KEGG Gene (Homo sapiens):5106 PCK2

Monarch:5106 PCK2

NCBI Gene:5106 PCK2

OMIM:614095 PCK2

UCSC:Q16822 PCK2

Reference Transcript

Other Identifiers

11719089_a_at

11728867_a_at

16782548

202847_PM_at

202847_at

3529509

3529510

3529511

3529512

3529513

3529514

3529515

3529517

3529518

3529519

3529520

3529521

3529522

3529525

3529528

3529531

3529532

3529537

3529539

3529541

3529542

3529543

3529544

3529545

37188_at

5106

7973530

86118_at

A_23_P140207

A_33_P3268532

GE60154

GO:0000166

GO:0003824

GO:0004611

GO:0004613

GO:0005515

GO:0005525

GO:0005739

GO:0005759

GO:0005829

GO:0005975

GO:0006090

GO:0006094

GO:0006107

GO:0006116

GO:0006629

GO:0016301

GO:0016310

GO:0016740

GO:0016829

GO:0016831

GO:0017076

GO:0019543

GO:0023052

GO:0030145

GO:0030154

GO:0032024

GO:0032496

GO:0032869

GO:0042594

GO:0043226

GO:0046327

GO:0046872

GO:0048856

GO:0070365

GO:0071333

GO:0071356

GO:0071548

GO:0071549

HMNXSV003014613

HMNXSV003043724

ILMN_1671791

ILMN_1760649

ILMN_1802699

PH_hs_0004373

TC14000157.hg

X92720_at

g4758885_3p_at

Inferred To

pck-2 [mitochondrial matrix] (Caenorhabditis elegans)

PCK2 [mitochondrial matrix] (Bos taurus)

PCK2 [mitochondrial matrix] (Canis familiaris)

PCK2 [mitochondrial matrix] (Dictyostelium discoideum)

PCK2 [mitochondrial matrix] (Drosophila melanogaster)

PCK2 [mitochondrial matrix] (Gallus gallus)

PCK2 [mitochondrial matrix] (Mus musculus)

PCK2 [mitochondrial matrix] (Sus scrofa)

pck2 [mitochondrial matrix] (Danio rerio)

Pck2 [mitochondrial matrix] (Rattus norvegicus)

Cross References

RefSeq

NP_001018083.2, NP_004554.3, NP_001278485.1, NP_001294983.1

OpenTargets

ENSG00000100889

IntEnz

4.1.1.32

HPA

ENSG00000100889-PCK2

GeneCards

Q16822

Ensembl

ENSP00000496343, ENSP00000496102, ENST00000644679, ENSP00000454011, ENST00000645709, ENSP00000380171, ENSG00000100889, ENSP00000441826, ENST00000216780, ENSP00000216780, ENST00000545054, ENST00000396973, ENST00000645217, ENST00000645536, ENST00000561286, ENSP00000494029, ENSG00000285241, ENSP00000494919

PRO

Q16822

Pharos - Targets

Q16822

Orphanet

16622

HMDB Protein

HMDBP00890

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UBW7 ZMYM2	6	ZMYM2(1-913)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1839016) ZMYM2(1-913)-FGFR1(429-822) fusion [cytosol] (R-HSA-1604544) ZMYM2(1-1059)-p-4Y-FLT3(594-993) fusion [cytosol] (R-HSA-9703309) ZMYM2(1-1057)-p-5Y-FLT3(586-993) fusion [cytosol] (R-HSA-9703319) ZMYM2(1-1059)-FLT3(594-993) fusion [cytosol] (R-HSA-9703310) ZMYM2(1-1057)-FLT3(586-993) fusion [cytosol] (R-HSA-9703311)	0.527	3
UniProt:P17677 GAP43	2	PALM-C3,4-GAP43 [plasma membrane] (R-HSA-8933482) GAP43 [plasma membrane] (R-HSA-452888)	0.527	2
UniProt:Q96DA0 PAUF			0.527	2
UniProt:Q9UMX1 SUFU	3	SUFU [ciliary base] (R-HSA-5610424) SUFU [cytosol] (R-HSA-445455) SUFU [ciliary tip] (R-HSA-5610426)	0.527	3
UniProt:O75380 NDUFS6	1	NDUFS6 [mitochondrial inner membrane] (R-HSA-163922)	0.527	2
UniProt:Q9GZZ8 LACRT			0.527	2
UniProt:P35558 PCK1	1	PCK1 [cytosol] (R-HSA-70495)	0.527	2
UniProt:Q8TDL5 BPIFB1	1	BPIFB1 [extracellular region] (R-HSA-6809282)	0.527	2
UniProt:Q9NP55 BPIFA1	1	BPIFA1 [extracellular region] (R-HSA-6809280)	0.527	2
UniProt:Q9HC84 MUC5B	18	Core 8 (MUC5B) [Golgi lumen] (R-HSA-1462102) Core 2S (MUC5B) [Golgi lumen] (R-HSA-6786324) Core 5 (MUC5B) [Golgi lumen] (R-HSA-1462075) Core 4 (MUC5B) [Golgi lumen] (R-HSA-1462291) Core 3 (MUC5B) [Golgi lumen] (R-HSA-1462201) Core 7 (MUC5B) [Golgi lumen] (R-HSA-1462327) GalNAc-MUC5B(26-5703) [plasma membrane] (R-HSA-8858460) Core 2 (MUC5B) [Golgi lumen] (R-HSA-1462273) Core 2a (MUC5B) [Golgi lumen] (R-HSA-6784272) GalNAc-MUC5B(26-5703) [Golgi lumen] (R-HSA-1463435) Sialyl Tn antigen (MUC5B) [Golgi lumen] (R-HSA-1463478) T-antigen (MUC5B) [Golgi lumen] (R-HSA-1462213) Sialyl-2,3 T-antigen (MUC5B) [Golgi lumen] (R-HSA-1463597) Sialyl T-antigen (MUC5B) [Golgi lumen] (R-HSA-1463481) Disialyl T-antigen (MUC5B) [Golgi lumen] (R-HSA-1463459) MUC5B(26-5703) [Golgi lumen] (R-HSA-913676) Core 6 (MUC5B) [Golgi lumen] (R-HSA-1462242) extended Core 6 (MUC5B) [Golgi lumen] (R-HSA-1967031)	0.527	2
UniProt:P13196 ALAS1	2	PXLP-ALAS1 [mitochondrial matrix] (R-HSA-1022086) ALAS1 [mitochondrial matrix] (R-HSA-189438)	0.527	2
UniProt:P01877 IGHA2	1	IGHA2 [extracellular region] (R-HSA-1478812)	0.527	2
UniProt:P01876 IGHA1	1	IGHA1 [extracellular region] (R-HSA-1478809)	0.527	2
UniProt:P84022 SMAD3	20	Ub-SMAD3 [cytosol] (R-HSA-6782830) p-S423,S425-SMAD3 D258N [cytosol] (R-HSA-3315470) p-S423,S425-SMAD3 R268C [cytosol] (R-HSA-3315075) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080) SMAD3 Q316* [cytosol] (R-HSA-9668765) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 S425C [cytosol] (R-HSA-3308499) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 [nucleoplasm] (R-HSA-206150) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471)	0.508	2
UniProt:Q9BXC9 BBS2	1	BBS2 [cytosol] (R-HSA-5617637)	0.508	2
UniProt:P10809 HSPD1	6	HSPD1 [mitochondrial matrix] (R-HSA-1299448) HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171)	0.483	2

Cite Us!