oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix]

Stable Identifier
R-HSA-372819
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix]
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PCK2 (phosphoenolcarboxykinase), located in the mitochondrial matrix, catalyzes the physiologically irreversible reaction of oxaloacetate and GTP to form phosphoenolpyruvate, GDP, and CO2 (Modaressi et al. 1996, 1998).

Literature References
PubMed ID Title Journal Year
9657976 Human mitochondrial phosphoenolpyruvate carboxykinase 2 gene. Structure, chromosomal localization and tissue-specific expression

Modaressi, S, Brechtel, K, Christ, B, Jungermann, K

Biochem J 1998
8645161 Molecular cloning, sequencing and expression of the cDNA of the mitochondrial form of phosphoenolpyruvate carboxykinase from human liver

Modaressi, S, Christ, B, Bratke, J, Zahn, S, Heise, T, Jungermann, K

Biochem J 1996
Participants
Input
Output
Participates
as an event of
Catalyst Activity

phosphoenolpyruvate carboxykinase (GTP) activity of PCK2 [mitochondrial matrix]

Physical Entity
PCK2 [mitochondrial matrix] (Homo sapiens)
Activity
phosphoenolpyruvate carboxykinase (GTP) activity (GO:0004613)
Orthologous Events
oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix] (Bos taurus)
oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix] (Caenorhabditis elegans)
oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix] (Canis familiaris)
oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix] (Danio rerio)
oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix] (Dictyostelium discoideum)
oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix] (Drosophila melanogaster)
oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix] (Gallus gallus)
oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix] (Mus musculus)
oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix] (Rattus norvegicus)
oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix] (Sus scrofa)
oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix] (Xenopus tropicalis)
Cross References
Rhea
Authored
D'Eustachio, P  (2008-09-13)
Reviewed
Harris, RA  (2008-09-10)
Created
D'Eustachio, P  (2008-07-04)
Cite Us!