Reactome | ERBB3-1 [plasma membrane]

ERBB3-1 [plasma membrane]

Stable Identifier

R-HSA-372885

Type

Genes and Transcripts [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

ErbB3 isoform-1

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by ERBB2 in Cancer (Homo sapiens)
    - Signaling by ERBB2 KD Mutants (Homo sapiens)
      - ERBB2 KD mutants heterodimerize (Homo sapiens)
        
        Heterodimers of ERBB2 KD mutants [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants:Ligand-Activated EGFR,(ERBB3,ERBB4) [plasma membrane] (Homo sapiens)
        
        Ligand-Activated EGFR,(ERBB3,ERBB4) [plasma membrane] (Homo sapiens)
        
        NRG1/2:ERBB3 [plasma membrane] (Homo sapiens)
        
        ERBB3-1 [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants:Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
        
        Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
        
        NRG1/2:ERBB3 [plasma membrane] (Homo sapiens)
        
        ERBB3-1 [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants:Ligand-Activated ERBB3,(EGFR,ERBB4) [plasma membrane] (Homo sapiens)
        
        Ligand-Activated ERBB3,(EGFR,ERBB4) [plasma membrane] (Homo sapiens)
        
        NRG1/2:ERBB3 [plasma membrane] (Homo sapiens)
        
        ERBB3-1 [plasma membrane] (Homo sapiens)
        
        Ligand-Activated (EGFR,ERBB3,ERBB4) [plasma membrane] (Homo sapiens)
        
        Ligand-Activated EGFR,(ERBB3,ERBB4) [plasma membrane] (Homo sapiens)
        
        NRG1/2:ERBB3 [plasma membrane] (Homo sapiens)
        
        ERBB3-1 [plasma membrane] (Homo sapiens)
        
        Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
        
        NRG1/2:ERBB3 [plasma membrane] (Homo sapiens)
        
        ERBB3-1 [plasma membrane] (Homo sapiens)
        
        Ligand-Activated ERBB3,(EGFR,ERBB4) [plasma membrane] (Homo sapiens)
        
        NRG1/2:ERBB3 [plasma membrane] (Homo sapiens)
        
        ERBB3-1 [plasma membrane] (Homo sapiens)
      - ERBB2 KD mutants trans-autophosphorylate (Homo sapiens)
        
        Heterodimers of ERBB2 KD mutants [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants:Ligand-Activated EGFR,(ERBB3,ERBB4) [plasma membrane] (Homo sapiens)
        
        Ligand-Activated EGFR,(ERBB3,ERBB4) [plasma membrane] (Homo sapiens)
        
        NRG1/2:ERBB3 [plasma membrane] (Homo sapiens)
        
        ERBB3-1 [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants:Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
        
        Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
        
        NRG1/2:ERBB3 [plasma membrane] (Homo sapiens)
        
        ERBB3-1 [plasma membrane] (Homo sapiens)
        
        ERBB2 KD mutants:Ligand-Activated ERBB3,(EGFR,ERBB4) [plasma membrane] (Homo sapiens)
        
        Ligand-Activated ERBB3,(EGFR,ERBB4) [plasma membrane] (Homo sapiens)
        
        NRG1/2:ERBB3 [plasma membrane] (Homo sapiens)
        
        ERBB3-1 [plasma membrane] (Homo sapiens)
    - Signaling by ERBB2 TMD/JMD mutants (Homo sapiens)
      - ERBB2 TMD/JMD heterodimers trans-autophosphorylate (Homo sapiens)
        
        ERBB2 TMD/JMD mutants:Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
        
        Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
        
        NRG1/2:ERBB3 [plasma membrane] (Homo sapiens)
        
        ERBB3-1 [plasma membrane] (Homo sapiens)
      - ERBB2 TMD/JMD mutants hetrodimerize (Homo sapiens)
        
        ERBB2 TMD/JMD mutants:Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
        
        Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
        
        NRG1/2:ERBB3 [plasma membrane] (Homo sapiens)
        
        ERBB3-1 [plasma membrane] (Homo sapiens)
        
        Ligand-Activated EGFR,ERBB3,(ERBB4) [plasma membrane] (Homo sapiens)
        
        NRG1/2:ERBB3 [plasma membrane] (Homo sapiens)
        
        ERBB3-1 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P21860-1 ERBB3

Gene Names

ERBB3, HER3

Other Identifiers

11721445_x_at

11734393_at

11747025_a_at

1563253_3p_s_at

1563253_PM_s_at

1563253_s_at

1585_at

16752397

1723_g_at

1742_at

202454_PM_s_at

202454_s_at

2065

2089_s_at

226213_PM_at

226213_at

3170522

32787_at

33639_g_at

3417250

3417251

3417252

3417253

3417254

3417255

3417256

3417257

3417259

3417260

3417262

3417264

3417266

3417267

3417268

3417270

3417272

3417275

3417276

3417279

3417281

3417283

3417284

3417285

3417286

3417287

3417289

3417292

3417294

3417295

3417296

3417298

3417299

3417300

3417301

3417302

3417303

3417304

3417310

3417311

3417312

3417313

3417314

48563_at

70142_at

7956120

A_14_P135292

A_14_P135669

A_23_P349416

A_33_P3211569

A_33_P3280471

GE59520

GO:0000166

GO:0003197

GO:0003824

GO:0004672

GO:0004713

GO:0004888

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005886

GO:0006468

GO:0007155

GO:0007162

GO:0007165

GO:0007166

GO:0007169

GO:0007422

GO:0007507

GO:0008284

GO:0009925

GO:0009968

GO:0010628

GO:0012501

GO:0014037

GO:0014044

GO:0016020

GO:0016301

GO:0016310

GO:0016323

GO:0016324

GO:0016328

GO:0016740

GO:0019838

GO:0021545

GO:0022008

GO:0023052

GO:0030154

GO:0030296

GO:0031625

GO:0036211

GO:0038023

GO:0038131

GO:0038132

GO:0038133

GO:0038143

GO:0042060

GO:0042127

GO:0042552

GO:0042802

GO:0043066

GO:0043125

GO:0043235

GO:0043491

GO:0043524

GO:0046982

GO:0048856

GO:0051048

GO:0051402

GO:0051897

GO:0055025

GO:0060089

GO:0070886

GO:0097049

GO:0097192

GO:0098590

GO:0098772

GO:0140096

GO:2000672

HMNXSV003022334

HMNXSV003033668

Hs.199067.2.A1_3p_at

Hs2.430933.1.S1_3p_s_at

ILMN_1737993

ILMN_1751346

ILMN_2397602

M34309_at

PH_hs_0032594

S61953_at

TC12002388.hg

TC12003243.hg

g4503596_3p_a_at

Participates

as an input of

as a component of

Other forms of this molecule

p-10Y-ERBB3-1 [plasma membrane]

Inferred To

ERBB3-1 [plasma membrane] (Bos taurus)

ERBB3-1 [plasma membrane] (Caenorhabditis elegans)

ERBB3-1 [plasma membrane] (Canis familiaris)

ERBB3-1 [plasma membrane] (Danio rerio)

ERBB3-1 [plasma membrane] (Drosophila melanogaster)

ERBB3-1 [plasma membrane] (Gallus gallus)

ERBB3-1 [plasma membrane] (Mus musculus)

ERBB3-1 [plasma membrane] (Rattus norvegicus)

ERBB3-1 [plasma membrane] (Sus scrofa)

ERBB3-1 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001005915.1, NP_001973.2

ZINC - World Drugs

ERBB3_HUMAN

Guide to Pharmacology - Targets

1798

OpenTargets

ENSG00000065361

ZINC - FDA approved

ERBB3_HUMAN

ZINC - Substances

ERBB3_HUMAN

ZINC - Biogenic

ERBB3_HUMAN

ZINC target

P21860

PRO

P21860

PDB

7D85, 7MN5, 3KEX, 4RIY, 7BHE, 1M6B, 4RIX, 5O4O, 7MN6, 2L9U, 6OP9, 3LMG, 7BHF, 4P59, 3P11, 5CUS, 6KBI, 5O7P, 4RIW, 4LEO, 7MN8

ZINC - Investigational

ERBB3_HUMAN

HPA

ENSG00000065361-ERBB3

GeneCards

P21860

Ensembl

ENSP00000408340, ENST00000415288, ENST00000683059, ENSG00000065361, ENST00000683164, ENST00000683018, ENST00000551242, ENST00000267101, ENSP00000508051, ENSP00000506822, ENSP00000415753, ENSP00000507402, ENST00000411731, ENSP00000447510, ENSP00000267101

Pharos - Targets

P21860

Orphanet

17461

ZINC - Predictions - Purchasable

ERBB3_HUMAN

HMDB Protein

HMDBP01167

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.973	30
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.921	41
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.919	14
UniProt:P29353 SHC1	5	p-Y427-SHC1 [cytosol] (R-HSA-74684) p-Y349,Y350-SHC1 [cytosol] (R-HSA-180276) p-Y349,Y350,Y427-SHC1 [cytosol] (R-HSA-912321) SHC1 [cytosol] (R-HSA-74680) p-Y-SHC1 [cytosol] (R-HSA-162568)	0.762	7
UniProt:P42336 PIK3CA	20	PIK3CA H1047L [cytosol] (R-HSA-1500714) PIK3CA H1047R [cytosol] (R-HSA-1500716) PIK3CA M1043I [cytosol] (R-HSA-1500719) PIK3CA M1043T [cytosol] (R-HSA-2395934) PIK3CA M1043V [cytosol] (R-HSA-2395932) PIK3CA H1047Y [cytosol] (R-HSA-1500720) PIK3CA E542K [cytosol] (R-HSA-1500701) PIK3CA Q546K [cytosol] (R-HSA-1500705) PIK3CA E545A [cytosol] (R-HSA-2362355) PIK3CA E545K [cytosol] (R-HSA-1500706) PIK3CA E545Q [cytosol] (R-HSA-2362362) PIK3CA Q546E [cytosol] (R-HSA-2362383) PIK3CA E545V [cytosol] (R-HSA-2362365) PIK3CA E542V [cytosol] (R-HSA-2328074) PIK3CA Q546L [cytosol] (R-HSA-2362375) PIK3CA E545G [cytosol] (R-HSA-1500709) PIK3CA Q546H [cytosol] (R-HSA-2362374) PIK3CA Q546R [cytosol] (R-HSA-2362373) PIK3CA Q546P [cytosol] (R-HSA-1500695) PIK3CA E542Q [cytosol] (R-HSA-2328003)	0.723	18
UniProt:Q14451 GRB7	1	GRB7 [cytosol] (R-HSA-204819)	0.688	7
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.678	5
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.564	3
UniProt:P04271 S100B	1	S100B [extracellular region] (R-HSA-879433)	0.556	3
UniProt:P25098 GRK2	4	p-S29-ADRBK1 [cytosol] (R-HSA-9645318) ADRBK1 [cilium] (R-HSA-5632504) p-S29-ADRBK1 [plasma membrane] (R-HSA-111969) GRK2 [plasma membrane] (R-HSA-50270)	0.556	3
UniProt:O75688 PPM1B	3	PPM1B [cytosol] (R-HSA-1169375) PPM1B(2-282)-ALK(1058-1620) fusion [cytosol] (R-HSA-9713477) PPM1B(2-282)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9713479)	0.553	2
UniProt:Q9UBN7 HDAC6	4	HDAC6 [nucleoplasm] (R-HSA-351589) HDAC6 [late endosome lumen] (R-HSA-9659980) HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [lysosomal lumen] (R-HSA-9660002)	0.553	2
UniProt:O15431 SLC31A1	1	SLC31A1 [plasma membrane] (R-HSA-437299)	0.527	2
UniProt:P27824 CANX	2	CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.483	3
UniProt:Q9UBS4 DNAJB11	1	DNAJB11 [endoplasmic reticulum lumen] (R-HSA-381040)	0.483	2

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