Receptors CCR3, 4 and 5 bind CCL5 ligand

Stable Identifier
R-HSA-373061
Type
Reaction [binding]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Three receptors have a common CC chemokine CCL5 that can signal through them. CCR3 (Combadiere C et al, 1995) is highly expressed in eosinophils and basophils and also found in airway epithelial cells, thus implicating this receptor in allergic reactions. CCR4 (Power CA et al, 1995) is expressed in Th2 T lymphocytes and upregulated by T-cell receptor activation. CCR5 (Samson M et al, 1996) mediates the recruitment of cells involved in immune and inflammatory processes.
Literature References
PubMed ID Title Journal Year
8639485 Molecular cloning and functional expression of a new human CC-chemokine receptor gene

Samson, M, Mollereau, C, Parmentier, M, Vassart, G, Labbe, O

Biochemistry 1996
7622448 Cloning and functional expression of a human eosinophil CC chemokine receptor

Murphy, PM, Combadiere, C, Ahuja, SK

J Biol Chem 1995
7642634 Molecular cloning and functional expression of a novel CC chemokine receptor cDNA from a human basophilic cell line

Power, CA, Proudfoot, AE, Wells, TN, Meyer, A, Hoogewerf, AJ, Bacon, KB, Nemeth, K

J Biol Chem 1995
Participants
Participates
Orthologous Events
Authored
Reviewed
Created
Cite Us!