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SUMO1-C173-UBA2 [nucleoplasm]
Stable Identifier
R-HSA-3730628
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
SUMO1 S-glycyl-cys173 UBA2, SUMO-activating enzyme subunit 2, SAE2_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
Processing and activation of SUMO (Homo sapiens)
SUMO is conjugated to E1 (UBA2:SAE1) (Homo sapiens)
Conjugation of SUMO1 to UBA2:SAE1 (Homo sapiens)
SUMO1:UBA2:SAE1 [nucleoplasm] (Homo sapiens)
SUMO1:UBA2 [nucleoplasm] (Homo sapiens)
SUMO1-C173-UBA2 [nucleoplasm] (Homo sapiens)
SUMO is transferred from E1 to E2 (UBE2I, UBC9) (Homo sapiens)
Transfer of SUMO1 from E1 to UBE2I (UBC9) (Homo sapiens)
SUMO1:UBA2:SAE1 [nucleoplasm] (Homo sapiens)
SUMO1:UBA2 [nucleoplasm] (Homo sapiens)
SUMO1-C173-UBA2 [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
11481243
Expression and regulation of the mammalian SUMO-1 E1 enzyme
Cavenagh, MM
,
Azuma, Y
,
Tan, SH
,
Saitoh, H
,
Ainsztein, AM
,
Dasso, M
FASEB J.
2001
External Reference Information
External Reference
UniProt:Q9UBT2 UBA2
Gene Names
UBA2, SAE2, UBLE1B, HRIHFB2115
Chain
chain:1-640
Reference Genes
BioGPS Gene:10054 UBA2
COSMIC (genes):UBA2 UBA2
CTD Gene:10054 UBA2
dbSNP Gene:10054 UBA2
ENSEMBL:ENSG00000126261 UBA2
ENSEMBL_homo_sapiens_GENE:ENSG00000126261.13 UBA2
HGNC:30661 UBA2
KEGG Gene (Homo sapiens):10054 UBA2
Monarch:10054 UBA2
NCBI Gene:10054 UBA2
OMIM:613295 UBA2
UCSC:Q9UBT2 UBA2
Reference Transcript
RefSeq:NM_005499.2 UBA2
Other Identifiers
10054
11717530_a_at
11717531_x_at
11749584_a_at
11758626_s_at
16860746
201177_PM_s_at
201177_s_at
229587_PM_at
229587_at
2345219
2928376
2928377
2928378
2928380
34814_at
3829769
3829770
3829771
3829773
3829774
3829777
3829778
3829780
3829787
3829788
3829790
3829791
3829792
3829793
3829795
3829798
3829800
3829804
3829808
3829809
3829810
3829811
3829812
3829813
3829814
74323_at
8027650
A_24_P376229
A_24_P926935
GE79556
GO:0000166
GO:0000287
GO:0003824
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0008641
GO:0016740
GO:0016874
GO:0016925
GO:0019948
GO:0031510
GO:0032183
GO:0033235
GO:0036211
GO:0043226
GO:0044388
GO:0044390
GO:0046872
GO:0046982
GO:0140096
GO:0140657
HMNXSV003054824
Hs.4311.1.A1_3p_at
ILMN_1742872
PH_hs_0028596
PH_hs_0040878
TC19000444.hg
g4885648_3p_a_at
g4885648_3p_x_at
Participates
as a component of
SUMO1:UBA2 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
SUMO3-C173-UBA2 [nucleoplasm]
SUMO2-C173-UBA2 [nucleoplasm]
UBA2 [nucleoplasm]
Inferred To
UBA2 [nucleoplasm]
(Canis familiaris)
SUMO1-C173-UBA2 [nucleoplasm]
(Bos taurus)
SUMO1-C173-UBA2 [nucleoplasm]
(Caenorhabditis elegans)
SUMO1-C173-UBA2 [nucleoplasm]
(Danio rerio)
SUMO1-C173-UBA2 [nucleoplasm]
(Dictyostelium discoideum)
SUMO1-C173-UBA2 [nucleoplasm]
(Gallus gallus)
SUMO1-C173-UBA2 [nucleoplasm]
(Mus musculus)
SUMO1-C173-UBA2 [nucleoplasm]
(Rattus norvegicus)
SUMO1-C173-UBA2 [nucleoplasm]
(Saccharomyces cerevisiae)
SUMO1-C173-UBA2 [nucleoplasm]
(Schizosaccharomyces pombe)
SUMO1-C173-UBA2 [nucleoplasm]
(Sus scrofa)
SUMO1-C173-UBA2 [nucleoplasm]
(Xenopus tropicalis)
Modified Residues
Name
Inter-chain Crosslink via S-(glycyl)-L-cysteine (Cys-Gly) at 173 and 97
Coordinate
173
PsiMod Name
S-(glycyl)-L-cysteine (Cys-Gly)
PsiMod Definition
A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.
Cross References
RefSeq
NP_005490.1
OpenTargets
ENSG00000126261
GeneCards
Q9UBT2
HPA
ENSG00000126261-UBA2
Ensembl
ENSP00000437484
,
ENST00000246548
,
ENST00000439527
,
ENSP00000246548
,
ENSG00000126261
PRO
Q9UBT2
Pharos - Targets
Q9UBT2
HMDB Protein
HMDBP09256
PDB
6XOH
,
5FQ2
,
4W5V
,
6XOG
,
1Y8Q
,
3KYC
,
3KYD
,
2PX9
,
6CWY
,
6XOI
,
1Y8R
,
6CWZ
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63165 SUMO1
11
lysyl-G97-SUMO1 [plasma membrane]
(R-HSA-9762382)
lysyl-G97-SUMO1 [nucleolus]
(R-HSA-9762385)
lysyl-G97-SUMO1 [viral capsid]
(R-HSA-9762386)
UBE2I-G97-SUMO1 [cytosol]
(R-HSA-4656941)
lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-9762380)
lysyl-G97-SUMO1 [cytosol]
(R-HSA-9762266)
UBE2I-G97-SUMO1 [nucleoplasm]
(R-HSA-3730622)
UBA2-G97-SUMO1 [nucleoplasm]
(R-HSA-3730616)
SUMO1 [nucleoplasm]
(R-HSA-877304)
SUMO1(2-101) [nucleoplasm]
(R-HSA-2990831)
lysyl-G97-SUMO1 [nucleoplasm]
(R-HSA-9761562)
0.85
9
UniProt:P63279 UBE2I
9
monoSUMO1-K14-UBE2I [nucleoplasm]
(R-HSA-4085358)
UBE2I [nuclear envelope]
(R-HSA-4655408)
SUMO2-C93-UBE2I [cytosol]
(R-HSA-4656944)
SUMO3-C93-UBE2I [nucleoplasm]
(R-HSA-3730629)
UBE2I [cytosol]
(R-HSA-4655342)
SUMO1-C93-UBE2I [cytosol]
(R-HSA-4656909)
SUMO2-C93-UBE2I [nucleoplasm]
(R-HSA-3730619)
SUMO1-C93-UBE2I [nucleoplasm]
(R-HSA-3730617)
UBE2I [nucleoplasm]
(R-HSA-912481)
0.85
9
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
6
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