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Class B/2 (Secretin family receptors)
Stable Identifier
R-HSA-373080
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class B/2 (Secretin family receptors) (Homo sapiens)
General
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This family is known as Family B (secretin-receptor family, family 2) G-protein-coupled receptors. Family B GPCRs include secretin, calcitonin, parathyroid hormone/parathyroid hormone-related peptides and vasoactive intestinal peptide receptors; all of which activate adenylyl cyclase and the phosphatidyl-inositol-calcium pathway (Harmar AJ, 2001).
Literature References
PubMed ID
Title
Journal
Year
11790261
Family-B G-protein-coupled receptors
Harmar, AJ
Genome Biol
2001
Participants
Events
Calcitonin-like ligand receptors
(Homo sapiens)
CRHBP binds CRH
(Homo sapiens)
CRHR1,CRHR2-1 binds CRH,UCN
(Homo sapiens)
CRHR2-2 binds CRH,UCN,UCN2,UCN3
(Homo sapiens)
Glucagon-type ligand receptors
(Homo sapiens)
Parathyroid hormone receptor can bind parathyroid hormone
(Homo sapiens)
Patched binds Smoothened
(Homo sapiens)
Frizzled receptors bind Wnts
(Homo sapiens)
EGF-TM7 receptors bind chondroitin sulphate
(Homo sapiens)
CD97 binds CD55
(Homo sapiens)
Participates
as an event of
GPCR ligand binding (Homo sapiens)
Orthologous Events
Class B/2 (Secretin family receptors) (Bos taurus)
Class B/2 (Secretin family receptors) (Caenorhabditis elegans)
Class B/2 (Secretin family receptors) (Canis familiaris)
Class B/2 (Secretin family receptors) (Danio rerio)
Class B/2 (Secretin family receptors) (Drosophila melanogaster)
Class B/2 (Secretin family receptors) (Gallus gallus)
Class B/2 (Secretin family receptors) (Mus musculus)
Class B/2 (Secretin family receptors) (Rattus norvegicus)
Class B/2 (Secretin family receptors) (Sus scrofa)
Class B/2 (Secretin family receptors) (Xenopus tropicalis)
Authored
Jassal, B (2008-07-14)
Reviewed
D'Eustachio, P (2009-05-29)
Created
Jassal, B (2008-07-14)
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