Reactome | Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta

Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta

Stable Identifier

R-HSA-373339

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Chemokine receptors bind chemokines (Homo sapiens)
        
        Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Homo sapiens)

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Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta

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Single C motif-1 (SCM-1; lymphotactin, CXC1) is a member of the chemokine receptor family (Yoshida T et al, 1995). CXC differs from the CC chemokines by one amino acid separating two of the four conserved cysteine residues (to give the motif CXC) whereas two adjacent cysteines denote CC. In humans, there are two highly conserved SCM-1 genes, SCYC1 and 2, which encode two SCM-1 proteins, SCM1-alpha and beta (Yoshida T et al, 1996). These proteins act as specific ligands for the CXC1 receptor. This receptor is highly expressed in placenta but lowly in spleen and thymus.

Literature References

PubMed ID	Title	Journal	Year
8849694	Structure and expression of two highly related genes encoding SCM-1/human lymphotactin Ishikawa, I, Yoshie, O, Nishimura, M, Takagi, S, Yoshida, T, Yaoi, T, Imai, T	FEBS Lett	1996
7875320	Molecular cloning of a novel C or gamma type chemokine, SCM-1 Yoshie, O, Nishimura, M, Yoshida, T, Kakizaki, M, Imai, T	FEBS Lett	1995
7602097	Molecular cloning and functional characterization of human lymphotactin Kelner, GS, Zlotnik, A, Yssel, H, Kleyensteuber, S, Bacon, KB, Schall, TJ, Weiss, MC, Kennedy, J, Schneider, PV, Cocks, BG	J Immunol	1995