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CASK [cytosol]
Stable Identifier
R-HSA-373631
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Peripheral plasma membrane protein CASK
Icon
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Nephrin family interactions (Homo sapiens)
Nephrin binds CASK (Homo sapiens)
CASK [cytosol] (Homo sapiens)
Nephrin dimer:CASK [plasma membrane] (Homo sapiens)
CASK [cytosol] (Homo sapiens)
Extracellular matrix organization (Homo sapiens)
Non-integrin membrane-ECM interactions (Homo sapiens)
Syndecan interactions (Homo sapiens)
Syndecan-2 binds CASK (Homo sapiens)
CASK [cytosol] (Homo sapiens)
Syndecan-2:CASK [plasma membrane] (Homo sapiens)
CASK [cytosol] (Homo sapiens)
Neuronal System (Homo sapiens)
Protein-protein interactions at synapses (Homo sapiens)
Neurexins and neuroligins (Homo sapiens)
NRXNs bind CASK:Protein 4.1 (Homo sapiens)
CASK:Protein 4.1 [cytosol] (Homo sapiens)
CASK [cytosol] (Homo sapiens)
NRXNs:NLGN dimers:CASK:Protein 4.1 [plasma membrane] (Homo sapiens)
CASK:Protein 4.1 [cytosol] (Homo sapiens)
CASK [cytosol] (Homo sapiens)
NRXNs binds CASK tripartite complex (Homo sapiens)
LIN7:CASK:APBA1 [plasma membrane] (Homo sapiens)
CASK [cytosol] (Homo sapiens)
NRXNs:LIN7:CASK:APBA1 [plasma membrane] (Homo sapiens)
LIN7:CASK:APBA1 [plasma membrane] (Homo sapiens)
CASK [cytosol] (Homo sapiens)
Protein 4.1 binds CASK (Homo sapiens)
CASK [cytosol] (Homo sapiens)
CASK:Protein 4.1 [cytosol] (Homo sapiens)
CASK [cytosol] (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Assembly and cell surface presentation of NMDA receptors (Homo sapiens)
GluN1:GluN2B (GRIN1:GRIN2B) di-heterotetramers bind LIN7:CASK:APBA1, DLG1 and KIF17 (Homo sapiens)
GRIN1:GRIN2B di-heterotetramer:LIN7:CASK:APBA1:DLG1:KIF17:Microtubule [transport vesicle membrane] (Homo sapiens)
LIN7:CASK:APBA1 [transport vesicle membrane] (Homo sapiens)
CASK [cytosol] (Homo sapiens)
LIN7:CASK:APBA1 [transport vesicle membrane] (Homo sapiens)
CASK [cytosol] (Homo sapiens)
KIF17 transports GluN1:GluN2B (GRIN1:GRIN2B) NMDA receptors to the plasma membrane (Homo sapiens)
GRIN1:GRIN2B di-heterotetramer:LIN7:CASK:APBA1:DLG1:KIF17:Microtubule [transport vesicle membrane] (Homo sapiens)
LIN7:CASK:APBA1 [transport vesicle membrane] (Homo sapiens)
CASK [cytosol] (Homo sapiens)
LIN7:CASK:APBA1 [transport vesicle membrane] (Homo sapiens)
CASK [cytosol] (Homo sapiens)
Neurotransmitter release cycle (Homo sapiens)
Dopamine Neurotransmitter Release Cycle (Homo sapiens)
Dopamine synaptic vesicle docking and priming (Homo sapiens)
LIN7:CASK:APBA1 [plasma membrane] (Homo sapiens)
CASK [cytosol] (Homo sapiens)
LIN7, CASK and APBA1 bind (Homo sapiens)
CASK [cytosol] (Homo sapiens)
LIN7:CASK:APBA1 [plasma membrane] (Homo sapiens)
CASK [cytosol] (Homo sapiens)
Sensory Perception (Homo sapiens)
Sensory processing of sound (Homo sapiens)
Sensory processing of sound by inner hair cells of the cochlea (Homo sapiens)
Mechanoelectrical transduction (MET) channel transports cations from the extracellular region into the cytosol of stereocilia of inner hair cell (Homo sapiens)
MET channel:Tip link:USH1C:USH1G:MYO7A:cytoskeleton (IHC) [plasma membrane] (Homo sapiens)
Inner hair cell stereocilium cytoskeleton [cytosol] (Homo sapiens)
Inner hair cell stereocilium tip [cytosol] (Homo sapiens)
CASK [cytosol] (Homo sapiens)
Sensory processing of sound by outer hair cells of the cochlea (Homo sapiens)
Mechanoelectrical transduction (MET) channel transports cations into the cytosol of stereocilia of cochlear outer hair cell (Homo sapiens)
MET channel:Tip link:USH1C:USH1G:MYO7A:cytoskeleton (OHC) [plasma membrane] (Homo sapiens)
Outer hair cell stereocilium cytoskeleton [cytosol] (Homo sapiens)
Outer hair cell stereocilium tip [cytosol] (Homo sapiens)
CASK [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14936 CASK
Gene Names
CASK, LIN2
Chain
chain:1-926
Reference Genes
BioGPS Gene:8573 CASK
COSMIC (genes):CASK CASK
CTD Gene:8573 CASK
dbSNP Gene:8573 CASK
ENSEMBL:ENSG00000147044 CASK
ENSEMBL_homo_sapiens_GENE:ENSG00000147044.23 CASK
HGNC:1497 CASK
KEGG Gene (Homo sapiens):8573 CASK
Monarch:8573 CASK
NCBI Gene:8573 CASK
OMIM:300172 CASK
UCSC:O14936 CASK
Reference Transcript
RefSeq:NM_003688.3 CASK
RefSeq:NM_001126055.2 CASK
RefSeq:NM_001126054.2 CASK
Other Identifiers
11721586_a_at
11729379_s_at
11729380_a_at
11758271_s_at
17110237
207620_PM_s_at
207620_s_at
211208_PM_s_at
211208_s_at
227156_PM_at
227156_at
238699_PM_s_at
238699_s_at
31854_at
36414_s_at
4005868
4005869
4005870
4005871
4005872
4005873
4005874
4005875
4005876
4005877
4005882
4005885
4005886
4005887
4005888
4005891
4005892
4005893
4005897
4005898
4005899
4005902
4005903
4005904
4005908
4005910
4005915
4005919
4005921
4005924
4005933
4005936
4005948
4005956
4005969
4005970
4005971
4005972
4005973
4005974
61707_at
8172158
8573
88441_g_at
A_24_P288722
A_32_P168464
GE87345
GO:0000166
GO:0001953
GO:0003824
GO:0004385
GO:0004672
GO:0004674
GO:0005102
GO:0005515
GO:0005516
GO:0005524
GO:0005604
GO:0005634
GO:0005652
GO:0005730
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0005911
GO:0005925
GO:0005929
GO:0006351
GO:0006355
GO:0006468
GO:0007155
GO:0010839
GO:0015629
GO:0016020
GO:0016192
GO:0016301
GO:0016310
GO:0016323
GO:0016363
GO:0016740
GO:0023052
GO:0030312
GO:0031012
GO:0031982
GO:0036211
GO:0042043
GO:0042060
GO:0042734
GO:0043226
GO:0045202
GO:0045944
GO:0046037
GO:0046710
GO:0046928
GO:0051649
GO:0055086
GO:0060170
GO:0061045
GO:0070509
GO:0090280
GO:0090288
GO:0098685
GO:0106310
GO:0140096
GO:1901135
GO:2000300
HMNXSV003022794
Hs.3327.0.S1_3p_at
ILMN_1654773
PH_hs_0000403
PH_hs_0023503
TC0X000969.hg
TC0X002040.hg
g13359270_3p_a_at
g4502566_3p_a_at
Participates
as a component of
Inner hair cell stereocilium tip [cytosol] (Homo sapiens)
Outer hair cell stereocilium tip [cytosol] (Homo sapiens)
Syndecan-2:CASK [plasma membrane] (Homo sapiens)
Nephrin dimer:CASK [plasma membrane] (Homo sapiens)
LIN7:CASK:APBA1 [plasma membrane] (Homo sapiens)
CASK:Protein 4.1 [cytosol] (Homo sapiens)
LIN7:CASK:APBA1 [plasma membrane] (Homo sapiens)
LIN7:CASK:APBA1 [transport vesicle membrane] (Homo sapiens)
as an input of
Syndecan-2 binds CASK (Homo sapiens)
Nephrin binds CASK (Homo sapiens)
Protein 4.1 binds CASK (Homo sapiens)
LIN7, CASK and APBA1 bind (Homo sapiens)
Inferred To
cask [cytosol]
(Xenopus tropicalis)
wu:fd08c05 [cytosol]
(Danio rerio)
lin-2 [cytosol]
(Caenorhabditis elegans)
CASK [cytosol]
(Bos taurus)
CASK [cytosol]
(Canis familiaris)
CASK [cytosol]
(Drosophila melanogaster)
CASK [cytosol]
(Gallus gallus)
CASK [cytosol]
(Rattus norvegicus)
CASK [cytosol]
(Sus scrofa)
Cask [cytosol]
(Mus musculus)
Cross References
RefSeq
NP_001119527.1
,
NP_001119526.1
,
NP_003679.2
ZINC - World Drugs
CSKP_HUMAN
Guide to Pharmacology - Targets
1959
OpenTargets
ENSG00000147044
ZINC - FDA approved
CSKP_HUMAN
ZINC - Substances
CSKP_HUMAN
ZINC - Biogenic
CSKP_HUMAN
ZINC target
O14936
PRO
O14936
PDB
7OAK
,
3C0I
,
6KMH
,
1ZL8
,
3MFR
,
3MFS
,
1KWA
,
7OAL
,
3MFT
,
3MFU
,
3TAC
,
1KGD
,
7OAJ
,
3C0G
,
3C0H
,
7OAI
ZINC - Investigational
CSKP_HUMAN
GeneCards
O14936
HPA
ENSG00000147044-CASK
Ensembl
ENSP00000367396
,
ENSP00000495291
,
ENST00000646120
,
ENST00000644347
,
ENST00000645566
,
ENSG00000147044
,
ENST00000378154
,
ENST00000378163
,
ENSP00000494788
,
ENSP00000494183
,
ENSP00000367405
Pharos - Targets
O14936
Orphanet
17592
ZINC - Predictions - Purchasable
CSKP_HUMAN
HMDB Protein
HMDBP08709
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O14910 LIN7A
2
LIN7A [plasma membrane]
(R-HSA-5216076)
LIN7A [transport vesicle membrane]
(R-HSA-9610413)
0.825
7
UniProt:Q13009 TIAM1
2
p-Y829-TIAM1 [cytosol]
(R-HSA-3928461)
TIAM1 [cytosol]
(R-HSA-195013)
0.678
3
UniProt:Q9H788 SH24A
0.666
4
UniProt:Q8WXD9 CSKI1
0.639
4
UniProt:Q63373 NRX1B
0.582
3
UniProt:Q9Y2J0 RP3A
0.581
3
UniProt:Q13425 SNTB2
0.564
3
UniProt:Q8VHK2 CSKI1
0.544
2
UniProt:Q96DR7 ARHGEF26
1
ARHGEF26 [cytosol]
(R-HSA-8873912)
0.527
2
UniProt:P34741 SDC2
20
SDC2 [plasma membrane]
(R-HSA-2090052)
p-Y179,Y191-SDC2 [plasma membrane]
(R-HSA-4093306)
SDC2 [lysosomal lumen]
(R-HSA-2090083)
HS(6)-SDC2 [lysosomal lumen]
(R-HSA-2090064)
HS(6)-SDC2 [Golgi lumen]
(R-HSA-2076588)
HS(5)-SDC2 [Golgi lumen]
(R-HSA-2076320)
Heparan-SDC2 [Golgi lumen]
(R-HSA-2076608)
Heparan(1)-SDC2 [Golgi lumen]
(R-HSA-2076536)
Heparan(2)-SDC2 [Golgi lumen]
(R-HSA-2076397)
Heparan(3)-SDC2 [Golgi lumen]
(R-HSA-2076361)
Heparan(4)-SDC2 [Golgi lumen]
(R-HSA-2076576)
HS(1)-SDC2 [Golgi lumen]
(R-HSA-2076607)
HS(2)-SDC2 [Golgi lumen]
(R-HSA-2076603)
HS(4)-SDC2 [Golgi lumen]
(R-HSA-2076356)
HS(3)-SDC2 [Golgi lumen]
(R-HSA-2076443)
GlcA-Gal-Gal-Xyl-SDC2 [Golgi lumen]
(R-HSA-2063997)
HS(4)-SDC2 [plasma membrane]
(R-HSA-2076683)
HS(6)-SDC2 [plasma membrane]
(R-HSA-2076661)
HS(2)-SDC2 [plasma membrane]
(R-HSA-2076644)
HS(1)-SDC2 [plasma membrane]
(R-HSA-2076643)
0.527
2
UniProt:Q12929 EPS8
1
EPS8 [cytosol]
(R-HSA-9662382)
0.524
3
UniProt:P41134 ID1
1
ID1 [nucleoplasm]
(R-HSA-2534101)
0.508
3
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