Reactome | YES1 [cytosol]

YES1 [cytosol]

Stable Identifier

R-HSA-373640

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Proto-oncogene tyrosine-protein kinase Yes

Locations in the PathwayBrowser for interactor UniProt:Q8TAK6 OLIG1

Expand all

External Reference Information

External Reference

UniProt:P07947 YES1

Gene Names

YES1, YES

Chain

initiator methionine:, chain:2-543

Reference Genes

BioGPS Gene:7525 YES1

COSMIC (genes):YES1 YES1

CTD Gene:7525 YES1

dbSNP Gene:7525 YES1

ENSEMBL:ENSG00000176105 YES1

HGNC:12841 YES1

KEGG:hsa:7525 YES1

Monarch:7525 YES1

NCBI Gene:7525 YES1

OMIM:164880 YES1

UCSC:P07947 YES1

Reference Transcript

Other Identifiers

11719415_a_at

1674_at

16853445

202932_PM_at

202932_at

202933_PM_s_at

202933_s_at

2521765

3795939

3795941

3795943

3795944

3795945

3795946

3795950

3795952

3795954

3795958

3795959

3795962

3795965

3795966

3795967

3795970

3795971

3795977

3795982

3795990

3795991

3795992

3795993

3795994

3795995

3795996

3940656

3940657

3940661

7525

8021984

A_23_P164507

A_24_P48403

GE62489

GO:0001784

GO:0002376

GO:0002862

GO:0003013

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0005102

GO:0005515

GO:0005524

GO:0005737

GO:0005794

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0005925

GO:0006355

GO:0006468

GO:0007169

GO:0010827

GO:0016740

GO:0019899

GO:0030154

GO:0031295

GO:0036120

GO:0036211

GO:0038096

GO:0043114

GO:0043226

GO:0044325

GO:0045087

GO:0045944

GO:0048013

GO:0048870

GO:0050731

GO:0050900

GO:0070062

GO:0071300

GO:0071560

GO:0098542

GO:0140096

HMNXSV003042499

ILMN_1691466

M15990_at

PH_hs_0035676

TC18000278.hg

g4885660_3p_a_at

Participates

as a component of

CSF1 dimer,IL34 dimer:PolyUb,p-8Y-CSF1R dimer:p-Y-CBL:GRB2:SOS1:p-Y-GAB2:p-Y-GAB3:GRAP2:INPP5D:INPPL1:PI3K:PTPN11:p-Y-SHC1:p-Y-PLCG2 [plasma membrane] (Homo sapiens)

as an input of

PIK3R1:PIK3CA,B,D (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated (Homo sapiens)

as a member of

as a candidate of

FYN-like kinases [cytosol] (Homo sapiens)

Other forms of this molecule

MyrG-p-Y426-YES1 [plasma membrane]

Inferred To

YES1 [cytosol] (Bos taurus)

YES1 [cytosol] (Caenorhabditis elegans)

YES1 [cytosol] (Canis familiaris)

YES1 [cytosol] (Danio rerio)

YES1 [cytosol] (Drosophila melanogaster)

YES1 [cytosol] (Gallus gallus)

YES1 [cytosol] (Mus musculus)

YES1 [cytosol] (Rattus norvegicus)

YES1 [cytosol] (Sus scrofa)

YES1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

XP_016881449.1, NP_005424.1

ZINC - World Drugs

YES_HUMAN

Guide to Pharmacology - Targets

2284

OpenTargets

ENSG00000176105

ENSEMBL

ENSP00000462468, ENST00000314574, ENSP00000324740, ENST00000584307

ZINC - FDA approved

YES_HUMAN

ZINC - Substances

YES_HUMAN

ZINC - Biogenic

YES_HUMAN

ZINC target

P07947

PRO

P07947

GlyGen

P07947

PDB

2HDA

ZINC - Investigational

YES_HUMAN

HPA

ENSG00000176105-YES1

Pharos - Targets

P07947

ZINC - Predictions - Purchasable

YES_HUMAN

HMDB Protein

HMDBP01230

Interactors (71)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.744	6
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.718	6
UniProt:Q9Y4K3 TRAF6	8	TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233)	0.718	6
UniProt:O14543 SOCS3	1	SOCS3 [cytosol] (R-HSA-873794)	0.718	6
UniProt:P51116 FXR2			0.718	6
UniProt:I6L996 I6L996			0.718	6
UniProt:Q96BR9 ZBT8A			0.718	6
UniProt:Q9NVV9 THAP1			0.718	6
UniProt:Q9BWW4 SSBP3			0.718	6
UniProt:Q8IVP5 FUNDC1	4	p-S17-FUNDC1 [mitochondrial outer membrane] (R-HSA-8948140) p-S13,Y18-FUNDC1 [mitochondrial outer membrane] (R-HSA-8934915) FUNDC1 [mitochondrial outer membrane] (R-HSA-8934922) p-S13-FUNDC1 [mitochondrial outer membrane] (R-HSA-8934910)	0.666	4
UniProt:P09769 FGR	3	FGR [cytosol] (R-HSA-432116) FGR [secretory granule lumen] (R-HSA-6804974) FGR [extracellular region] (R-HSA-6806524)	0.643	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	12
UniProt:Q8TAK6 OLIG1			0.57	3
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.564	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.564	3
UniProt:Q9H5V8 CDCP1			0.564	2
UniProt:Q9NR46 SHLB2			0.556	3
UniProt:P51114-2 FXR1			0.556	3
UniProt:Q96D03 DDT4L			0.556	3
UniProt:P17661 DES	1	DES [cytosol] (R-HSA-390570)	0.556	3
UniProt:Q9H257-2 CARD9			0.556	3
UniProt:Q92569 PIK3R3	2	PIK3R3 [cytosol] (R-HSA-205223) K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574)	0.556	3
UniProt:Q9NUP9 LIN7C	2	LIN7C [plasma membrane] (R-HSA-5216165) LIN7C [transport vesicle membrane] (R-HSA-9610411)	0.556	3
UniProt:Q13191 CBLB	1	CBLB [cytosol] (R-HSA-976009)	0.556	3
UniProt:P49023-2 PXN			0.556	3
UniProt:Q9Y2J4 AMOTL2	1	AMOTL2 [cytosol] (R-HSA-2028606)	0.556	3
IntAct:EBI-16439879 CCSB ORF ID			0.556	3
UniProt:Q68D51-2 DENND2C			0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:Q96N16 JKIP1			0.556	3
UniProt:Q14847-2 LASP1			0.556	3
UniProt:Q6P1W5 CA094			0.556	3
UniProt:Q8N9I9 DTX3			0.556	3
UniProt:Q96Q35-2 FLACC1			0.556	3
UniProt:Q9HD42 CHMP1A	1	CHMP1A [cytosol] (R-HSA-917721)	0.556	3
UniProt:P46109 CRKL	2	CRKL [cytosol] (R-HSA-354384) p-CRKL [cytosol] (R-HSA-9024730)	0.556	3
UniProt:Q9UGK3 STAP2	2	STAP2 [cytosol] (R-HSA-8848028) p-Y250-STAP2 [plasma membrane] (R-HSA-8848079)	0.556	3
UniProt:P56945 BCAR1	4	BCAR1 [cytosol] (R-HSA-201625) p-Y165,Y664-BCAR1 [cytosol] (R-HSA-8848723) p-Y12-BCAR1 [cytosol] (R-HSA-5218739) p-Y-BCAR1 [cytosol] (R-HSA-372645)	0.556	3
UniProt:P14136 GFAP	3	p-GFAP [lysosomal membrane] (R-HSA-9626054) GFAP [lysosomal membrane] (R-HSA-9625195) GFAP [cytosol] (R-HSA-1253311)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:O60496 DOK2	1	DOK2 [cytosol] (R-HSA-204823)	0.556	3
UniProt:O14508 SOCS2	1	SOCS2 [cytosol] (R-HSA-1169204)	0.556	3
UniProt:Q7Z4V0 ZN438			0.556	3
UniProt:Q9GZT8 NIF3L			0.556	3
UniProt:Q15428 SF3A2	1	SF3A2 [nucleoplasm] (R-HSA-71964)	0.556	3
UniProt:Q8TD16-2 BICD2			0.556	3
UniProt:Q16630-2 CPSF6	1	CPSF6-2 [nucleoplasm] (R-HSA-72014)	0.556	3
UniProt:O95995 GAS8	1	GAS8 [cytosol] (R-HSA-5633057)	0.556	3
UniProt:Q3SY00 T10IP			0.556	3
UniProt:Q9C035-3 TRIM5			0.556	3
UniProt:Q9ULV8 CBLC			0.556	3
UniProt:Q96GY0 ZC21A			0.556	3
UniProt:Q8IYX8 CE57L			0.556	3
UniProt:Q9UKT9 IKZF3			0.556	5
UniProt:O14512 SOCS7			0.556	3
UniProt:O43281-2 EFS			0.556	5
UniProt:Q9Y592-2 CEP83			0.556	3
UniProt:Q7Z3E2 CC186			0.527	2
UniProt:Q13503 MED21	1	MED21 [nucleoplasm] (R-HSA-212456)	0.527	2
UniProt:Q8NFB2 T185A			0.527	2
UniProt:Q58FG1 HS904			0.527	2
UniProt:Q58FG0 HS905			0.527	2
UniProt:Q58FF6 H90B4			0.527	2
UniProt:Q58FF7 H90B3			0.527	3
UniProt:P09067 HXB5			0.527	2
UniProt:P06239 LCK	4	LCK [cytosol] (R-HSA-167609) p-Y394-LCK [cytosol] (R-HSA-202308) p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [plasma membrane] (R-HSA-8857940)	0.527	3
UniProt:P05120 SERPINB2	2	SERPINB2 [plasma membrane] (R-HSA-159004) SERPINB2 [extracellular region] (R-HSA-158997)	0.527	2
UniProt:Q9H204 MED28	1	MED28 [nucleoplasm] (R-HSA-6804546)	0.524	2
UniProt:P25445-1 FAS			0.499	2
UniProt:Q14457 BECN1	4	BECN1 [cytosol] (R-HSA-1632841) p-S15-BECN1 [cytosol] (R-HSA-5682391) ISG15-K-BECN1 [cytosol] (R-HSA-9853030) K63polyUb-BECN1 [cytosol] (R-HSA-6782989)	0.488	2
UniProt:Q08345-1 DDR1			0.462	7

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