Reactome | CXCR2 [plasma membrane]

CXCR2 [plasma membrane]

Stable Identifier

R-HSA-373796

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

High affinity interleukin-8 receptor B, IL8RB

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P25025 CXCR2

Gene Names

CXCR2, IL8RB

Chain

chain:1-360

Reference Genes

BioGPS Gene:3579 CXCR2

COSMIC (genes):CXCR2 CXCR2

CTD Gene:3579 CXCR2

dbSNP Gene:3579 CXCR2

ENSEMBL:ENSG00000180871 CXCR2

HGNC:6027 CXCR2

KEGG:hsa:3579 CXCR2

Monarch:3579 CXCR2

NCBI Gene:3579 CXCR2

OMIM:146928 CXCR2

UCSC:P25025 CXCR2

Reference Transcript

Other Identifiers

1032_at

1033_g_at

11731423_at

11731424_x_at

11731425_at

11731426_s_at

16890752

207008_PM_at

207008_at

2527581

2527582

2527583

2527584

2527585

2527586

2527587

2527588

2527589

2527590

2527591

2527592

2527593

2599306

2599309

3579

664_at

8048227

A_14_P111718

A_14_P112492

A_23_P135755

A_24_P933228

A_33_P3214550

GE57658

GO:0002376

GO:0002407

GO:0004918

GO:0004930

GO:0005515

GO:0005654

GO:0005764

GO:0005773

GO:0005856

GO:0005886

GO:0006935

GO:0006954

GO:0006955

GO:0006968

GO:0007165

GO:0007166

GO:0007186

GO:0007200

GO:0007204

GO:0008284

GO:0009897

GO:0009986

GO:0015630

GO:0016020

GO:0016192

GO:0016493

GO:0016494

GO:0019722

GO:0019957

GO:0019959

GO:0030593

GO:0030667

GO:0031623

GO:0038112

GO:0042119

GO:0042629

GO:0043226

GO:0048870

GO:0060089

GO:0070098

GO:0072686

HMNXSV003009552

ILMN_1680397

L19593_at

PH_hs_0000102

TC02001292.hg

TC02003831.hg

TC02003832.hg

U11872_at

U11875_s_at

U11877_at

g4504682_3p_at

p33872

Participates

as a member of

Secretory granule membrane proteins [plasma membrane] (Homo sapiens)

as an input of

Receptor CXCR2 binds ligands CXCL1 to 7 (Homo sapiens)

as a component of

CXCR2:CXCR2 ligands [plasma membrane] (Homo sapiens)

Other forms of this molecule

CXCR2 [secretory granule membrane]

Inferred To

npr-32 [plasma membrane] (Caenorhabditis elegans)

Homologues of CXCR2 [plasma membrane] (Sus scrofa)

CXCR1 [plasma membrane] (Bos taurus)

CXCR1 [plasma membrane] (Gallus gallus)

cxcr2 [plasma membrane] (Xenopus tropicalis)

Cxcr2 [plasma membrane] (Mus musculus)

Cxcr2 [plasma membrane] (Rattus norvegicus)

CXCR2 [plasma membrane] (Canis familiaris)

CXCR2 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

XP_005246587.1, NP_001548.1, XP_016859480.1, NP_001161770.1, XP_016859479.1, XP_016859481.1

ZINC - World Drugs

CXCR2_HUMAN

Guide to Pharmacology - Targets

OpenTargets

ENSG00000180871

ENSEMBL

ENSP00000319635, ENST00000318507

ZINC - FDA approved

CXCR2_HUMAN

ZINC - Substances

CXCR2_HUMAN

ZINC target

P25025

PRO

P25025

GlyGen

P25025

PDB

6LFM, 6LFO, 6KVA, 4Q3H, 6KVF, 5TYT

ZINC - Investigational

CXCR2_HUMAN

HPA

ENSG00000180871-CXCR2

Pharos - Targets

P25025

Orphanet

CXCR2

ZINC - Predictions - Purchasable

CXCR2_HUMAN

HMDB Protein

HMDBP07642

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P46940 IQGAP1	3	IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [plasma membrane] (R-HSA-381681)	0.685	12
UniProt:P10145 CXCL8	1	IL8 [extracellular region] (R-HSA-447095)	0.609	3
UniProt:Q8N7P3 CLDN22	2	CLDN22 [plasma membrane] (R-HSA-432976) CLDN22 [cell junction] (R-HSA-434612)	0.556	3
UniProt:Q9BVK8 TM147			0.556	3
UniProt:Q96HE8 TMM80			0.556	3
UniProt:A5PKU2 A5PKU2			0.556	3
UniProt:Q14318 FKBP8	2	PolyUb-FKBP8 [mitochondrial outer membrane] (R-HSA-6783001) FKBP8 [mitochondrial outer membrane] (R-HSA-5696928)	0.556	3
UniProt:Q9NP94 SLC39A2	1	SLC39A2 [plasma membrane] (R-HSA-442395)	0.556	3
UniProt:P54849 EMP1			0.556	3
UniProt:Q05940 SLC18A2	2	SLC18A2 [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-372544) SLC18A2 [plasma membrane] (R-HSA-374907)	0.556	3
UniProt:Q8WVX3-2 C4ORF3			0.556	3
UniProt:Q9NRQ5 SMCO4			0.556	3
UniProt:Q9HD20-3 ATP13A1			0.556	3
UniProt:P04233 CD74	13	CD74(81-104) [lysosomal lumen] (R-HSA-2213220) CD74(81-104) [lysosomal membrane] (R-HSA-2130446) CD74(1-117) [lysosomal membrane] (R-HSA-2130632) CD74 [lumenal side of endoplasmic reticulum membrane] (R-HSA-1181241) CD74 [ER to Golgi transport vesicle membrane] (R-HSA-2130456) CD74 [Golgi membrane] (R-HSA-2214388) CD74 [trans-Golgi network membrane] (R-HSA-2130493) CD74 [transport vesicle membrane] (R-HSA-2130624) CD74 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130522) CD74 [endocytic vesicle membrane] (R-HSA-2130460) CD74(1-176) [lysosomal membrane] (R-HSA-2130602) CD74 [lysosomal membrane] (R-HSA-2130320) CD74 [plasma membrane] (R-HSA-2130666)	0.524	2
UniProt:Q13304-2 GPR17			0.524	3
UniProt:P04441	13	Cd74 [lysosomal lumen] (R-MMU-2213220) Cd74 [lysosomal membrane] (R-MMU-2130446) Cd74 [lysosomal membrane] (R-MMU-2130632) Cd74 [lumenal side of endoplasmic reticulum membrane] (R-MMU-1181241) Cd74 [ER to Golgi transport vesicle membrane] (R-MMU-2130456) Cd74 [Golgi membrane] (R-MMU-2214388) Cd74 [trans-Golgi network membrane] (R-MMU-2130493) Cd74 [transport vesicle membrane] (R-MMU-2130624) Cd74 [clathrin-coated endocytic vesicle membrane] (R-MMU-2130522) Cd74 [endocytic vesicle membrane] (R-MMU-2130460) Cd74 [lysosomal membrane] (R-MMU-2130602) Cd74 [lysosomal membrane] (R-MMU-2130320) Cd74 [plasma membrane] (R-MMU-2130666)	0.463	2

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