BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region

Stable Identifier
R-HSA-373875
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
lactate + H+ [cytosol] <=> lactate + H+ [extracellular]
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The membrane-associated MCT:basigin complex mediates the reversible export of cytosolic lactate and H+ (Wilson et al. 2005).
Literature References
PubMed ID Title Journal Year
15917240 Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70)

Meredith, D, Davies, AJ, Halestrap, AP, Fox, JE, Wilson, MC, Manoharan, C

J Biol Chem 2005
Participants
Participates
Catalyst Activity

lactate transmembrane transporter activity of BSG:MCTs [plasma membrane]

Orthologous Events
Cross References
RHEA
Rhea
Authored
Created
Cite Us!