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AGT(34-41) [extracellular region]
Stable Identifier
R-HSA-374187
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Angiotensin-2, Angiotensin-(1-8), Angiotensin II, ANGT_HUMAN, AGT, ANG1-8
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Metabolism of Angiotensinogen to Angiotensins (Homo sapiens)
ACE2(18-805):Zn2+ hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Homo sapiens)
AGT(34-41) [extracellular region] (Homo sapiens)
ACE:Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Homo sapiens)
AGT(34-41) [extracellular region] (Homo sapiens)
Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Homo sapiens)
AGT(34-41) [extracellular region] (Homo sapiens)
Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Homo sapiens)
AGT(34-41) [extracellular region] (Homo sapiens)
Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Homo sapiens)
AGT(34-41) [extracellular region] (Homo sapiens)
ENPEP:Zn2+ hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Homo sapiens)
AGT(34-41) [extracellular region] (Homo sapiens)
Secreted ACE:Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Homo sapiens)
AGT(34-41) [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
AGTR2:AGT(34-41) [plasma membrane] (Homo sapiens)
AGT(34-41) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
AGTR2:AGT(34-41) [plasma membrane] (Homo sapiens)
AGT(34-41) [extracellular region] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
AGTR2:AGT(34-41) [plasma membrane] (Homo sapiens)
AGT(34-41) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
AGTR2:AGT(34-41) [plasma membrane] (Homo sapiens)
AGT(34-41) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
AGTR2:AGT(34-41) [plasma membrane] (Homo sapiens)
AGT(34-41) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
AGTR2:AGT(34-41) [plasma membrane] (Homo sapiens)
AGT(34-41) [extracellular region] (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Type 1 angiotensin II receptor:Angiotensin II [plasma membrane] (Homo sapiens)
AGT(34-41) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Type 1 angiotensin II receptor:Angiotensin II [plasma membrane] (Homo sapiens)
AGT(34-41) [extracellular region] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Type 1 angiotensin II receptor:Angiotensin II [plasma membrane] (Homo sapiens)
AGT(34-41) [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Type 1 angiotensin II receptor:Angiotensin II [plasma membrane] (Homo sapiens)
AGT(34-41) [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Type 1 angiotensin II receptor:Angiotensin II [plasma membrane] (Homo sapiens)
AGT(34-41) [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
AGT(34-41) [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
AGT(34-41) binds to AGTR1 (Homo sapiens)
AGT(34-41) [extracellular region] (Homo sapiens)
AGTR1:AGT(34-41) [plasma membrane] (Homo sapiens)
AGT(34-41) [extracellular region] (Homo sapiens)
AGT(34-41) binds to AGTR2 (Homo sapiens)
AGT(34-41) [extracellular region] (Homo sapiens)
AGTR2:AGT(34-41) [plasma membrane] (Homo sapiens)
AGT(34-41) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01019 AGT
Gene Names
AGT, SERPINA8
Chain
signal peptide:1-24, chain:25-476, peptide:25-34, peptide:25-33, peptide:25-32, peptide:25-31, peptide:25-29, peptide:25-28, peptide:26-32, peptide:27-32
Reference Genes
COSMIC (genes):AGT AGT
dbSNP Gene:183 AGT
ENSEMBL:ENSG00000135744 AGT
Participates
as a component of
Type 1 angiotensin II receptor:Angiotensin II [plasma membrane] (Homo sapiens)
AGTR1:AGT(34-41) [plasma membrane] (Homo sapiens)
AGTR2:AGT(34-41) [plasma membrane] (Homo sapiens)
as an input of
ACE2(18-805):Zn2+ hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Homo sapiens)
ENPEP:Zn2+ hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8) (Homo sapiens)
AGT(34-41) binds to AGTR2 (Homo sapiens)
AGT(34-41) binds to AGTR1 (Homo sapiens)
as an output of
Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Homo sapiens)
Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Homo sapiens)
Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Homo sapiens)
ACE:Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Homo sapiens)
Secreted ACE:Zn2+ hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8) (Homo sapiens)
as a member of
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
Other forms of this molecule
AGT(36-41) [extracellular region]
AGT(35-41) [extracellular region]
AGT(34-40) [extracellular region]
AGT(34-42) [extracellular region]
AGT [extracellular region]
AGT(34-43) [extracellular region]
Inferred To
Spn42Da [extracellular region]
(Drosophila melanogaster)
Agt [extracellular region]
(Mus musculus)
Agt [extracellular region]
(Rattus norvegicus)
srp-6 [extracellular region]
(Caenorhabditis elegans)
Spn28Da [extracellular region]
(Drosophila melanogaster)
AGT [extracellular region]
(Bos taurus)
AGT [extracellular region]
(Canis familiaris)
AGT [extracellular region]
(Sus scrofa)
Spn88Eb [extracellular region]
(Drosophila melanogaster)
Spn27A [extracellular region]
(Drosophila melanogaster)
Homologues of AGT(34-41) [extracellular region]
(Caenorhabditis elegans)
Homologues of AGT(34-41) [extracellular region]
(Drosophila melanogaster)
srp-2 [extracellular region]
(Caenorhabditis elegans)
Acp76A [extracellular region]
(Drosophila melanogaster)
Spn100A [extracellular region]
(Drosophila melanogaster)
Spn42Dd [extracellular region]
(Drosophila melanogaster)
srp-8 [extracellular region]
(Caenorhabditis elegans)
Spn43Aa [extracellular region]
(Drosophila melanogaster)
Spn47C [extracellular region]
(Drosophila melanogaster)
AGT(34-41) [extracellular region]
(Caenorhabditis elegans)
AGT(34-41) [extracellular region]
(Gallus gallus)
Dmel\CG43366 [extracellular region]
(Drosophila melanogaster)
srp-7 [extracellular region]
(Caenorhabditis elegans)
Spn42Db [extracellular region]
(Drosophila melanogaster)
Spn75F [extracellular region]
(Drosophila melanogaster)
Spn28Db [extracellular region]
(Drosophila melanogaster)
Spn55B [extracellular region]
(Drosophila melanogaster)
nec [extracellular region]
(Drosophila melanogaster)
Spn31A [extracellular region]
(Drosophila melanogaster)
Spn43Ab [extracellular region]
(Drosophila melanogaster)
Spn53F [extracellular region]
(Drosophila melanogaster)
Spn88Ea [extracellular region]
(Drosophila melanogaster)
srp-1 [extracellular region]
(Caenorhabditis elegans)
Spn38F [extracellular region]
(Drosophila melanogaster)
agt [extracellular region]
(Danio rerio)
agt [extracellular region]
(Xenopus tropicalis)
srp-3 [extracellular region]
(Caenorhabditis elegans)
Spn42Dc [extracellular region]
(Drosophila melanogaster)
Spn42De [extracellular region]
(Drosophila melanogaster)
Spn28B [extracellular region]
(Drosophila melanogaster)
Spn85F [extracellular region]
(Drosophila melanogaster)
Spn28F [extracellular region]
(Drosophila melanogaster)
Spn43Ad [extracellular region]
(Drosophila melanogaster)
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q10714
2
ACE(30-1232) [extracellular region]
(R-DME-2065414-2)
ACE(30-1306) [plasma membrane]
(R-DME-508496-2)
0.558
2
UniProt:P00797 REN
3
REN [extracellular region]
(R-HSA-2022343)
REN(24-406) [plasma membrane]
(R-HSA-2065391)
REN [plasma membrane]
(R-HSA-2022352)
0.558
2
UniProt:Q9UI10 EIF2B4
1
EIF2B4 [cytosol]
(R-HSA-72521)
0.556
3
UniProt:Q9UMY4 SNX12
0.556
3
UniProt:O43493-5 O434935
0.556
3
UniProt:C9J082 C9J082
0.556
3
UniProt:O00746 NME4
1
NME4 [mitochondrial inner membrane]
(R-HSA-60026)
0.556
3
UniProt:Q8IYM2 SLN12
0.556
3
UniProt:CCDC26 A0A024R9H7
0.556
3
UniProt:Q8NFB2 T185A
0.556
3
UniProt:Q8TAS3 Q8TAS3
0.556
3
UniProt:Q8N0U8 VKORC1L1
1
VKORC1L1 [endoplasmic reticulum membrane]
(R-HSA-2980944)
0.556
3
UniProt:O14744 PRMT5
3
PRMT5 [cytosol]
(R-HSA-191876)
PRMT5 [nucleoplasm]
(R-HSA-5205609)
p-Y297,304,307-PRMT5 [nucleoplasm]
(R-HSA-5211300)
0.556
3
UniProt:O95167 NDUFA3
1
NDUFA3 [mitochondrial inner membrane]
(R-HSA-60180)
0.527
2
UniProt:P11021 HSPA5
6
HSPA5 [lumenal side of endoplasmic reticulum membrane]
(R-HSA-985498)
HSPA5 [nucleoplasm]
(R-HSA-5252042)
HSPA5 [cytosol]
(R-HSA-5252115)
HSPA5 [endoplasmic reticulum membrane]
(R-HSA-351315)
HSPA5 [endoplasmic reticulum lumen]
(R-HSA-387190)
HSPA5 [extracellular region]
(R-HSA-351322)
0.527
2
UniProt:P27824 CANX
2
CANX [endoplasmic reticulum lumen]
(R-HSA-195906)
CANX [lumenal side of endoplasmic reticulum membrane]
(R-HSA-983091)
0.527
2
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