Reactome | DARC is a non-specific receptor for many chemokines

DARC is a non-specific receptor for many chemokines

Stable Identifier

R-HSA-374251

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

DARC is a non-specific receptor for many chemokines

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The Duffy blood group system consists of two antigens defining four phenotypes (Marsh WL, 1975). Duffy antigen/receptor for chemokines (DARC) (Chaudhuri A et al, 1993) carries the Duffy (Fy) blood group and acts as a widely expressed promiscuous chemokine receptor. The chemokine interleukin-8 is one example shown here.

Literature References

PubMed ID	Title	Journal	Year
8248172	Cloning of glycoprotein D cDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the Plasmodium vivax malaria parasite Polyakova, J, Pogo, AO, Gulati, S, Chaudhuri, A, Zbrzezna, V, Williams, K	Proc Natl Acad Sci U S A	1993
12956774	Structure-function analysis of the extracellular domains of the Duffy antigen/receptor for chemokines: characterization of antibody and chemokine binding sites Filipe, A, Tournamille, C, Lisowska, E, Cartron, JP, Gane, P, Le Van Kim, C, Colin, Y, Wasniowska, K	Br J Haematol	2003