Reactome | Apelin receptor binds to apelin

Apelin receptor binds to apelin

Stable Identifier

R-HSA-374337

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Apelin (Tatemoto K et al, 1998) is an endogenous ligand for the apelin (APJ) receptor (O'Dowd BF et al, 1993) and is widely expressed in the human body including the heart and brain. Apelin is one of the most potent stimulators of cardiac contractility and mediates blood pressure and blood flow. Several active peptides can be produced by proteolytic processing of the peptide precursor (apelin-36, 31, 28 and 13). APJ is related to the angiotensin receptor (40-50% identity) and couples to G proteins that inhibit adenylate cyclase activity. It is an alternative coreceptor with CD4 for HIV-1 infection. Binding of apelin to its receptor inhibits HIV-1 entry in cells coexpressing CD4 and APJ.

Literature References

PubMed ID	Title	Journal	Year
9792798	Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor Zou, MX, Kakegawa, T, Kitada, C, Kawamata, Y, Habata, Y, Onda, H, Tatemoto, K, Hinuma, S, Fujino, M, Fujii, R, Hosoya, M, Kurokawa, T, Fukusumi, S	Biochem Biophys Res Commun	1998
8294032	A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11 Nguyen, T, George, SR, Kennedy, JL, Chan, A, Shi, X, O'Dowd, BF, Heng, HH, Petronis, A, Tsui, LC, Heiber, M	Gene	1993