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ANK3 [cytosol]
Stable Identifier
R-HSA-374562
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Ankyrin-R, ANK3_HUMAN, Ankyrin-3
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
L1CAM interactions (Homo sapiens)
Interaction between L1 and Ankyrins (Homo sapiens)
Ankyrins link voltage-gated sodium and potassium channels to spectrin and L1 (Homo sapiens)
NFASC:NRCAM:ANK1-3:SPTA:SPTB:F-actin [plasma membrane] (Homo sapiens)
ANK1-3 [cytosol] (Homo sapiens)
ANK3 [cytosol] (Homo sapiens)
NFASC:NRCAM:ANK1-3:SPTA:SPTB:F-actin:KCNQ2,3, SCNAs:SCNBs [plasma membrane] (Homo sapiens)
NFASC:NRCAM:ANK1-3:SPTA:SPTB:F-actin [plasma membrane] (Homo sapiens)
ANK1-3 [cytosol] (Homo sapiens)
ANK3 [cytosol] (Homo sapiens)
L1 dimer binds Ankyrin (Homo sapiens)
ANK1-3 [cytosol] (Homo sapiens)
ANK3 [cytosol] (Homo sapiens)
L1 trans-homodimer:Ankyrin [plasma membrane] (Homo sapiens)
ANK1-3 [cytosol] (Homo sapiens)
ANK3 [cytosol] (Homo sapiens)
L1 linked to actin cytoskeleton by ankyrin (Homo sapiens)
L1 dimer:Ankyrin:Spectrin:F-actin [plasma membrane] (Homo sapiens)
L1 trans-homodimer:Ankyrin [plasma membrane] (Homo sapiens)
ANK1-3 [cytosol] (Homo sapiens)
ANK3 [cytosol] (Homo sapiens)
L1 trans-homodimer:Ankyrin [plasma membrane] (Homo sapiens)
ANK1-3 [cytosol] (Homo sapiens)
ANK3 [cytosol] (Homo sapiens)
Phosphorylation of Y1229 in L1 (Homo sapiens)
ANK1-3 [cytosol] (Homo sapiens)
ANK3 [cytosol] (Homo sapiens)
L1 trans-homodimer:Ankyrin [plasma membrane] (Homo sapiens)
ANK1-3 [cytosol] (Homo sapiens)
ANK3 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK3 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK3 [cytosol] (Homo sapiens)
ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK3 [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK3 [cytosol] (Homo sapiens)
COPI vesicle uncoating (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK3 [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK3 [cytosol] (Homo sapiens)
ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK3 [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK3 [cytosol] (Homo sapiens)
Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK3 [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK3 [cytosol] (Homo sapiens)
cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK3 [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK3 [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK3 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK3 [cytosol] (Homo sapiens)
ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK3 [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK3 [cytosol] (Homo sapiens)
COPI vesicle uncoating (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK3 [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK3 [cytosol] (Homo sapiens)
ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK3 [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK3 [cytosol] (Homo sapiens)
Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK3 [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK3 [cytosol] (Homo sapiens)
cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK3 [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q12955 ANK3
Gene Names
ANK3
Chain
chain:1-4377
Reference Genes
BioGPS Gene:288 ANK3
COSMIC (genes):ANK3 ANK3
CTD Gene:288 ANK3
dbSNP Gene:288 ANK3
ENSEMBL:ENSG00000151150 ANK3
ENSEMBL_homo_sapiens_GENE:ENSG00000151150.22 ANK3
HGNC:494 ANK3
KEGG Gene (Homo sapiens):288 ANK3
Monarch:288 ANK3
NCBI Gene:288 ANK3
OMIM:600465 ANK3
UCSC:Q12955 ANK3
Reference Transcript
RefSeq:NM_020987.4 ANK3
RefSeq:NM_001204403.1 ANK3
RefSeq:NM_001204404.1 ANK3
RefSeq:NM_001149.3 ANK3
Other Identifiers
11721204_a_at
11721205_a_at
11721206_x_at
11739926_a_at
16714618
206385_PM_s_at
206385_s_at
207950_PM_s_at
207950_s_at
209442_PM_x_at
209442_x_at
238786_PM_at
238786_at
288
3290874
3290876
3290877
3290878
3290879
3290880
3290881
3290882
3290903
3290906
3290908
3290909
3290916
3290917
3290919
3290920
3290921
3290922
3290923
3290924
3290925
3290926
3290927
3290928
3290929
3290932
3290933
3290934
3290936
3290937
3290938
3290939
3290943
3290944
3290951
3290954
3290955
3290957
3290960
3290965
3290968
3290977
3290978
3290980
3290981
3290982
3290983
3290984
3290988
3290991
3290995
3290997
3290998
3290999
3291000
3291001
3291002
3291003
3291004
3291005
3291006
3291009
3291016
3291019
3291023
3291024
3291025
3291026
3291027
3291028
3291050
3291051
3291088
3291095
3291106
3291107
36965_at
36967_g_at
50126_at
54588_at
71824_at
7933772
A_23_P202269
A_24_P162173
A_32_P33304
A_33_P3218783
GE58941
GO:0000278
GO:0000281
GO:0000910
GO:0005198
GO:0005200
GO:0005515
GO:0005737
GO:0005764
GO:0005773
GO:0005783
GO:0005794
GO:0005829
GO:0005856
GO:0005886
GO:0005923
GO:0006886
GO:0007009
GO:0007010
GO:0007155
GO:0007165
GO:0007409
GO:0007528
GO:0008092
GO:0008093
GO:0009925
GO:0009986
GO:0010628
GO:0010650
GO:0010765
GO:0010960
GO:0014704
GO:0014731
GO:0016020
GO:0016192
GO:0016323
GO:0016328
GO:0016529
GO:0019228
GO:0023052
GO:0030018
GO:0030154
GO:0030315
GO:0030424
GO:0030425
GO:0030507
GO:0030674
GO:0031594
GO:0033268
GO:0034112
GO:0034330
GO:0042383
GO:0042995
GO:0043001
GO:0043005
GO:0043034
GO:0043194
GO:0043226
GO:0043266
GO:0044325
GO:0045184
GO:0045202
GO:0045211
GO:0045296
GO:0045838
GO:0048856
GO:0050877
GO:0051179
GO:0055065
GO:0055085
GO:0060090
GO:0061024
GO:0071286
GO:0071709
GO:0072659
GO:0072660
GO:0090314
GO:0099612
GO:1900827
GO:1902260
GO:2000651
GO:2001259
HMNXSV003020542
HMNXSV003048043
Hs.28137.0.A1_3p_at
ILMN_1651943
ILMN_1661875
ILMN_2390609
PH_hs_0025787
TC10001319.hg
U13616_at
g10947055_3p_a_at
g12052939_3p_a_at
g4502092_3p_a_at
Participates
as a candidate of
ANK1-3 [cytosol] (Homo sapiens)
as a member of
Ankyrin [cytosol] (Homo sapiens)
Inferred To
Ank [cytosol]
(Drosophila melanogaster)
ANK3 [cytosol]
(Dictyostelium discoideum)
Homologues of ANK3 [cytosol]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_066267.2
,
NP_001140.2
,
NP_001191332.1
,
NP_001191333.1
OpenTargets
ENSG00000151150
GeneCards
Q12955
HPA
ENSG00000151150-ANK3
Ensembl
ENST00000280772
,
ENST00000373827
,
ENSG00000151150
,
ENST00000503366
,
ENSP00000347436
,
ENST00000355288
,
ENSP00000280772
,
ENSP00000362933
,
ENSP00000425236
PRO
Q12955
Pharos - Targets
Q12955
Orphanet
22237
PDB
4O6X
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15796 SMAD2
20
Ub-SMAD2 [cytosol]
(R-HSA-6782774)
p-S465,S467-SMAD2 P305L [cytosol]
(R-HSA-3315471)
p-S465,S467-SMAD2 D300A [cytosol]
(R-HSA-3315064)
p-S465,S467-SMAD2 D300N [cytosol]
(R-HSA-3315066)
p-S465,S467-SMAD2 A354T [cytosol]
(R-HSA-3315474)
p-S465,S467-SMAD2 P305Q [cytosol]
(R-HSA-3315070)
p-S465,S467-SMAD2 D300V [cytosol]
(R-HSA-3315067)
SMAD2 S464* [cytosol]
(R-HSA-3304362)
SMAD2 W422* [cytosol]
(R-HSA-9668736)
SMAD2 S308* [cytosol]
(R-HSA-9668732)
SMAD2 R427* [cytosol]
(R-HSA-9668733)
SMAD2 W448* [cytosol]
(R-HSA-9668734)
SMAD2 S464L [cytosol]
(R-HSA-3304383)
SMAD2 C463* [cytosol]
(R-HSA-9668735)
SMAD2 R321* [cytosol]
(R-HSA-9668728)
SMAD2 S296* [cytosol]
(R-HSA-9668729)
SMAD2 S306* [cytosol]
(R-HSA-9668730)
SMAD2 Q455* [cytosol]
(R-HSA-9668731)
SMAD2 E439* [cytosol]
(R-HSA-9668724)
SMAD2 L315* [cytosol]
(R-HSA-9668725)
0.573
2
UniProt:O00533 CHL1
1
CHL1 [plasma membrane]
(R-HSA-443615)
0.527
2
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