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SIAH2 [cytosol]
Stable Identifier
R-HSA-374566
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase SIAH2, SIAH2_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q7Z6J0 SH3RF1
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Netrin-1 signaling (Homo sapiens)
DCC interaction with SIAH2 (Homo sapiens)
SIAH2 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
USP13 binds SIAH2 (Homo sapiens)
SIAH2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43255 SIAH2
Gene Names
SIAH2
Chain
chain:1-324
Reference Genes
BioGPS Gene:6478 SIAH2
COSMIC (genes):SIAH2 SIAH2
CTD Gene:6478 SIAH2
dbSNP Gene:6478 SIAH2
ENSEMBL:ENSG00000181788 SIAH2
HGNC:10858 SIAH2
KEGG:hsa:6478 SIAH2
Monarch:6478 SIAH2
NCBI Gene:6478 SIAH2
OMIM:602213 SIAH2
UCSC:O43255 SIAH2
Reference Transcript
RefSeq:NM_005067.5 SIAH2
Other Identifiers
11743067_at
11743068_at
16960517
209339_PM_at
209339_at
2700829
2700830
2700831
2700832
2700843
2700844
2700845
2700846
2700847
2700848
2700849
2700850
2700851
33799_at
64001_s_at
6478
8091485
A_23_P69121
A_33_P3358342
GE59403
GO:0003714
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005768
GO:0005769
GO:0005829
GO:0006355
GO:0006511
GO:0006915
GO:0007264
GO:0007275
GO:0008270
GO:0012501
GO:0016567
GO:0016740
GO:0030163
GO:0031396
GO:0031410
GO:0031624
GO:0042752
GO:0043025
GO:0043066
GO:0043154
GO:0043161
GO:0043226
GO:0043231
GO:0045892
GO:0046872
GO:0048511
GO:0048856
GO:0060070
GO:0060090
GO:0061630
GO:0090090
GO:0140096
GO:0140110
GO:1990000
GO:2001237
HMNXSV003010165
ILMN_1801313
TC03001901.hg
g2673967_3p_at
Participates
as a component of
SIAH2:USP13 [cytosol] (Homo sapiens)
NTN1:DCC:SIAH2 [plasma membrane] (Homo sapiens)
as an input of
USP13 binds SIAH2 (Homo sapiens)
DCC interaction with SIAH2 (Homo sapiens)
as a member of
SIAH1, SIAH2 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
Dmel\CG2681 [cytosol]
(Drosophila melanogaster)
SIAH2 [cytosol]
(Bos taurus)
SIAH2 [cytosol]
(Caenorhabditis elegans)
SIAH2 [cytosol]
(Canis familiaris)
SIAH2 [cytosol]
(Danio rerio)
SIAH2 [cytosol]
(Drosophila melanogaster)
SIAH2 [cytosol]
(Gallus gallus)
SIAH2 [cytosol]
(Mus musculus)
SIAH2 [cytosol]
(Rattus norvegicus)
SIAH2 [cytosol]
(Sus scrofa)
Homologues of SIAH2 [cytosol]
(Drosophila melanogaster)
siah2 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_005058.3
ENSEMBL
ENST00000312960
,
ENSP00000322457
OpenTargets
ENSG00000181788
HPA
ENSG00000181788-SIAH2
PRO
O43255
Pharos - Targets
O43255
HMDB Protein
HMDBP09308
PDB
5H9M
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NRM7 LATS2
2
p-S872,T1041-LATS2 [cytosol]
(R-HSA-2028565)
LATS2 [cytosol]
(R-HSA-2028580)
0.632
6
UniProt:Q7Z6J0 SH3RF1
1
SH3RF1 [cytosol]
(R-HSA-5688968)
0.632
3
UniProt:P86478 PR20E
0.527
2
UniProt:O43900 PRIC3
0.527
2
UniProt:P35372 OPRM1
1
OPRM1 [plasma membrane]
(R-HSA-60951)
0.508
3
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