Translocation of Ezrin to plasma membrane

Stable Identifier
R-HSA-374662
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Translocation of Ezrin to plasma membrane
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Ezrin is a member of the ezrin/radixin/moesin (ERM) family that acts as a linker between the plasma membrane and the actin cytoskeleton. Ezrin exists in a dormant, monomeric form in which its FERM/NERMAD and C-ERMAD domains are associated, masking membrane and F-actin binding regions. On production of PIP2, ezrin binds it, is recruited to the plasma membrane, and undergoes conformational changes unmasking the two binding sites.
Literature References
PubMed ID Title Journal Year
12154370 ERM proteins and merlin: integrators at the cell cortex

Bretscher, A, Edwards, K, Fehon, RG

Nat Rev Mol Cell Biol 2002
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Orthologous Events
Translocation of Ezrin to plasma membrane (Bos taurus)
Translocation of Ezrin to plasma membrane (Caenorhabditis elegans)
Translocation of Ezrin to plasma membrane (Canis familiaris)
Translocation of Ezrin to plasma membrane (Danio rerio)
Translocation of Ezrin to plasma membrane (Drosophila melanogaster)
Translocation of Ezrin to plasma membrane (Gallus gallus)
Translocation of Ezrin to plasma membrane (Mus musculus)
Translocation of Ezrin to plasma membrane (Rattus norvegicus)
Translocation of Ezrin to plasma membrane (Sus scrofa)
Translocation of Ezrin to plasma membrane (Xenopus tropicalis)
Authored
Garapati, P V  (2008-07-16)
Reviewed
Cooper, HM  (2010-02-16)
Created
Garapati, P V  (2008-07-30)
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