Ezrin Radixin Moesin (ERM) are the members of the FERM domain (F for Band 4.1 protein, E for ezrin, R for radixin and M for moesin) containing proteins involved in localizing proteins to the plasma membrane. L1 is coupled to the tread milling actin cytoskeleton through interaction with ERM proteins. The motif KxxKYxV in the juxtamembrane region and the YRSLE sequence in L1CD are important for the ERM binding. This interaction provides a link between L1 and the actin cytoskeleton and plays a critical role in the traction force generation and regulation of neurite branching.