Interaction of L1 with Neurocan

Stable Identifier
R-HSA-374683
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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Interaction of L1 with Neurocan
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L1CAM binds with high affinity to the proteoglycan neurocan. Neurocan binds to the first Ig domain of L1CAM through its sushi module and a chondroitin sulphate chain. This interaction interferes with the homophilic interaction of L1CAM and inhibits neuronal adhesion and neurite extension mediated by L1CAM.
Participants
Input
Output
Entity On Other Cell
Participates
as an event of
Inferred From
Interaction of L1 with Neurocan (Mus musculus)
Authored
Garapati, P V  (2008-07-30)
Reviewed
Maness, PF  (2010-02-16)
Created
Garapati, P V  (2008-07-30)
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