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Phosphorylation of L1 by p90rsk
Stable Identifier
R-HSA-374696
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
L1CAM interactions (Homo sapiens)
Recycling pathway of L1 (Homo sapiens)
Phosphorylation of L1 by p90rsk (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
p90rsk associates with the internalized L1 in the endosomes and phosphorylates it at Ser1152. This phosphorylation may regulate the interactions of L1 and intracellular signaling cascades or cytoskeletal elements involved in neurite outgrowth on specific substrates.
Participants
Input
ATP [cytosol]
L1:AP-2 Clathrin complex [endosome]
(Homo sapiens)
p90rsk [cytosol]
(Homo sapiens)
Output
ADP [cytosol]
pL1 (S1152):p90rsk:clathrin-dynamin complex [endosome]
(Homo sapiens)
Participates
as an event of
Recycling pathway of L1 (Homo sapiens)
Catalyst Activity
protein serine/threonine kinase activity of p90rsk [cytosol]
Physical Entity
p90rsk [cytosol]
(Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
Phosphorylation of L1 by p90rsk (Homo sapiens)
Authored
Garapati, P V (2008-07-30)
Reviewed
Maness, PF (2010-02-16)
Created
Garapati, P V (2008-07-30)
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