Reactome | SSTR3 [plasma membrane]

SSTR3 [plasma membrane]

Stable Identifier

R-HSA-374732

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Somatostatin receptor type 3, SSR3_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR3 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR3 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR3 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR3 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR3 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR3 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Somatostatin receptors bind somatostatin and cortistatin (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR3 [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR3 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P32745 SSTR3

Gene Names

SSTR3

Chain

chain:1-418

Reference Genes

BioGPS Gene:6753 SSTR3

COSMIC (genes):SSTR3 SSTR3

CTD Gene:6753 SSTR3

dbSNP Gene:6753 SSTR3

ENSEMBL:ENSG00000278195 SSTR3

HGNC:11332 SSTR3

KEGG:hsa:6753 SSTR3

Monarch:6753 SSTR3

NCBI Gene:6753 SSTR3

OMIM:182453 SSTR3

UCSC:P32745 SSTR3

Reference Transcript

Other Identifiers

11740397_at

1553178_PM_a_at

1553178_a_at

16934743

214491_PM_at

214491_at

3960043

3960044

3960045

3960046

3960047

3960048

3960049

3960050

3960051

3960052

3960053

3960054

3960055

3960056

3960058

557_s_at

6753

8075906

A_23_P68910

GE848571

GO:0004930

GO:0004994

GO:0005102

GO:0005515

GO:0005886

GO:0005929

GO:0007186

GO:0007187

GO:0007218

GO:0007267

GO:0007283

GO:0008285

GO:0008628

GO:0016020

GO:0021549

GO:0022414

GO:0023052

GO:0030900

GO:0038170

GO:0042594

GO:0042923

GO:0043005

GO:0043226

GO:0048856

GO:0060089

GO:0060170

GO:0071385

GO:0071392

GO:0097730

HMNXSV003047328

Hs.225995.0.S1_3p_at

Hs2.225995.1.S1_3p_s_at

ILMN_1774749

ILMN_1872864

M96738_s_at

PH_hs_0026822

TC22000724.hg

TC22001334.hg

Z86000_at

Participates

as a member of

Other forms of this molecule

SSTR3 [ciliary membrane]

Inferred To

npr-16 [plasma membrane] (Caenorhabditis elegans)

npr-26 [plasma membrane] (Caenorhabditis elegans)

npr-24 [plasma membrane] (Caenorhabditis elegans)

Homologues of SSTR3 [plasma membrane] (Caenorhabditis elegans)

Sstr3 [plasma membrane] (Mus musculus)

Sstr3 [plasma membrane] (Rattus norvegicus)

npr-28 [plasma membrane] (Caenorhabditis elegans)

SS3R [plasma membrane] (Gallus gallus)

npr-18 [plasma membrane] (Caenorhabditis elegans)

sstr3 [plasma membrane] (Xenopus tropicalis)

SSTR3 [plasma membrane] (Bos taurus)

SSTR3 [plasma membrane] (Caenorhabditis elegans)

SSTR3 [plasma membrane] (Canis familiaris)

SSTR3 [plasma membrane] (Sus scrofa)

npr-23 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

XP_011528651.1, XP_006724374.1, NP_001042.1, XP_005261778.1, NP_001265616.1, XP_016884413.1, XP_016884412.1

ZINC - Investigational

SSR3_HUMAN

Guide to Pharmacology - Targets

357

ENSEMBL

ENST00000610913, ENSP00000481325, ENSP00000480971, ENST00000617123

OpenTargets

ENSG00000278195

HPA

ENSG00000278195-SSTR3

ZINC - Substances

SSR3_HUMAN

ZINC target

P32745

PRO

P32745

Pharos - Targets

P32745

GlyGen

P32745

ZINC - Predictions - Purchasable

SSR3_HUMAN

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3