Reactome | SSTR4 [plasma membrane]

SSTR4 [plasma membrane]

Stable Identifier

R-HSA-374745

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Somatostatin receptor type 4, SSR4_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR4 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR4 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR4 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR4 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR4 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR4 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Somatostatin receptors bind somatostatin and cortistatin (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR4 [plasma membrane] (Homo sapiens)
        
        Somatostatin receptors [plasma membrane] (Homo sapiens)
        
        SSTR4 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P31391 SSTR4

Gene Names

SSTR4

Chain

chain:1-388

Reference Genes

BioGPS Gene:6754 SSTR4

COSMIC (genes):SSTR4 SSTR4

CTD Gene:6754 SSTR4

dbSNP Gene:6754 SSTR4

ENSEMBL:ENSG00000132671 SSTR4

ENSEMBL_homo_sapiens_GENE:ENSG00000132671.6 SSTR4

HGNC:11333 SSTR4

KEGG Gene (Homo sapiens):6754 SSTR4

Monarch:6754 SSTR4

NCBI Gene:6754 SSTR4

OMIM:182454 SSTR4

UCSC:P31391 SSTR4

Reference Transcript

RefSeq:NM_001052.2 SSTR4

Other Identifiers

11735951_at

16912036

16912041

214556_PM_at

214556_at

34139_at

3880081

3880082

3880083

3880085

3880086

3880087

3880088

3880089

3880090

3880091

6754

8061366

ADDON002869.hg

A_14_P138292

A_33_P3414267

GE531856

GO:0004930

GO:0004994

GO:0005515

GO:0005886

GO:0007165

GO:0007186

GO:0007187

GO:0007218

GO:0008285

GO:0016020

GO:0016477

GO:0023052

GO:0030900

GO:0038170

GO:0042923

GO:0043005

GO:0048856

GO:0048870

GO:0060089

GO:0070374

GO:0071385

GO:0090238

GO:0106072

HMNXSV003031216

HMNXSV003048211

Hs.226015.0.S1_3p_at

L14856_at

TC20000150.hg

TC20000151.hg

Participates

as a member of

Somatostatin receptors [plasma membrane] (Homo sapiens)

Inferred To

sstr4 [plasma membrane] (Xenopus tropicalis)

Sstr4 [plasma membrane] (Mus musculus)

Sstr4 [plasma membrane] (Rattus norvegicus)

SSTR4 [plasma membrane] (Danio rerio)

SSTR4 [plasma membrane] (Gallus gallus)

Cross References

RefSeq

NP_001043.2

Guide to Pharmacology - Targets

358

OpenTargets

ENSG00000132671

ZINC - Substances

SSR4_HUMAN

ZINC target

P31391

PRO

P31391

PDB

7XMT, 7XMS

ZINC - Investigational

SSR4_HUMAN

GeneCards

P31391

HPA

ENSG00000132671-SSTR4

Ensembl

ENSP00000255008, ENSG00000132671, ENST00000255008

Pharos - Targets

P31391

ZINC - Predictions - Purchasable

SSR4_HUMAN