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SSTR2 [plasma membrane]
Stable Identifier
R-HSA-374757
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Somatostatin receptor type 2, SSR2_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
Somatostatin receptors [plasma membrane] (Homo sapiens)
SSTR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
Somatostatin receptors [plasma membrane] (Homo sapiens)
SSTR2 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
Somatostatin receptors [plasma membrane] (Homo sapiens)
SSTR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
Somatostatin receptors [plasma membrane] (Homo sapiens)
SSTR2 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
Somatostatin receptors [plasma membrane] (Homo sapiens)
SSTR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
Somatostatin receptors [plasma membrane] (Homo sapiens)
SSTR2 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Somatostatin receptors bind somatostatin and cortistatin (Homo sapiens)
Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
Somatostatin receptors [plasma membrane] (Homo sapiens)
SSTR2 [plasma membrane] (Homo sapiens)
Somatostatin receptors [plasma membrane] (Homo sapiens)
SSTR2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P30874 SSTR2
Gene Names
SSTR2
Chain
chain:1-369
Reference Genes
BioGPS Gene:6752 SSTR2
COSMIC (genes):SSTR2 SSTR2
CTD Gene:6752 SSTR2
dbSNP Gene:6752 SSTR2
ENSEMBL:ENSG00000180616 SSTR2
ENSEMBL_homo_sapiens_GENE:ENSG00000180616.9 SSTR2
HGNC:11331 SSTR2
KEGG Gene (Homo sapiens):6752 SSTR2
Monarch:6752 SSTR2
NCBI Gene:6752 SSTR2
OMIM:182452 SSTR2
UCSC:P30874 SSTR2
Reference Transcript
RefSeq:NM_001050.2 SSTR2
Other Identifiers
11739332_at
11739333_at
16837426
214597_3p_at
214597_PM_at
214597_at
217455_PM_s_at
217455_s_at
233310_3p_at
233310_PM_at
233310_at
239031_PM_at
239031_at
3733915
3733916
3733917
3733920
3733921
3733922
3733923
3733924
3733925
3733926
3733927
3733928
3733929
3733930
3733931
3733932
3733933
40919_at
54346_at
6752
8009526
84962_f_at
A_14_P133564
A_14_P136026
A_23_P318800
A_23_P38630
A_32_P6575
A_33_P3329013
A_33_P3352467
GE62630
GO:0003012
GO:0004930
GO:0004994
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0007165
GO:0007186
GO:0007187
GO:0007193
GO:0007218
GO:0007283
GO:0008285
GO:0016020
GO:0021549
GO:0022414
GO:0023052
GO:0030165
GO:0030432
GO:0030900
GO:0038170
GO:0042594
GO:0042923
GO:0043005
GO:0048856
GO:0060089
GO:0071385
GO:0071392
HMNXSV003012109
HMNXSV003027471
Hs.184841.0.S2_3p_x_at
Hs.184841.1.S1_3p_a_at
Hs.306358.0.S1_3p_at
Hs.306358.0.S1_3p_x_at
Hs.45177.0.A1_3p_at
ILMN_2152257
M81830_at
PH_hs_0026924
PH_hs_0029376
TC17000821.hg
TC17002346.hg
p7500
Participates
as a member of
Somatostatin receptors [plasma membrane] (Homo sapiens)
Inferred To
Sstr2 [plasma membrane]
(Mus musculus)
Sstr2 [plasma membrane]
(Rattus norvegicus)
SS2R [plasma membrane]
(Gallus gallus)
SSTR2 [plasma membrane]
(Bos taurus)
SSTR2 [plasma membrane]
(Canis familiaris)
SSTR2 [plasma membrane]
(Sus scrofa)
sstr2 [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001041.1
Guide to Pharmacology - Targets
356
OpenTargets
ENSG00000180616
ZINC - Substances
SSR2_HUMAN
ZINC target
P30874
PRO
P30874
PDB
7T11
,
7WJ5
,
7XAV
,
7Y26
,
7T10
,
7Y24
,
7XAU
,
7YAE
,
7UL5
,
7XAT
,
7XMR
,
7WIG
,
7YAC
,
7WIC
,
7Y27
ZINC - Investigational
SSR2_HUMAN
GeneCards
P30874
HPA
ENSG00000180616-SSTR2
Ensembl
ENSG00000180616
,
ENSP00000350198
,
ENST00000357585
Pharos - Targets
P30874
ZINC - Predictions - Purchasable
SSR2_HUMAN
HMDB Protein
HMDBP08008
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P27986 PIK3R1
16
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [cytosol]
(R-HSA-74789)
PIK3R1 [plasma membrane]
(R-HSA-198365)
0.639
5
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