Reactome | Somatostatin receptors bind somatostatin and cortistatin

Somatostatin receptors bind somatostatin and cortistatin

Stable Identifier

R-HSA-374758

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Somatostatin receptors bind somatostatin and cortistatin

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Somatostatin (growth hormone inhibiting hormone, GHIH; somatotropin release-inhibiting factor, SRIF) (Shen LP et al, 1992) is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with somatostatin receptors 1-5 (Hoyer D et al, 1995). Somatostatin has two active forms produced by alternative cleavage of the single preproprotein and named according to the number of amino acids in the chain; Somatostatin-28 and somatostatin-14. The 5 receptors known to date all couple with pertussis toxin-sensitive G proteins to inhibit adenylate cyclase after ligand binding. They were classified according to the dates they were discovered; SSTR1 and 2 (Yamada Y et al, Jan. 1992), SSTR3 (Yamada Y et al, Dec. 1992) and SSTR4 and SSTR5 (Yamada Y et al, Sep. 1993).

Literature References

PubMed ID	Title	Journal	Year
8373420	Cloning, functional expression and pharmacological characterization of a fourth (hSSTR4) and a fifth (hSSTR5) human somatostatin receptor subtype Li, Q, Ihara, Y, Yamada, Y, Kagimoto, S, Masuda, K, Yasuda, K, Seino, S, Someya, Y, Kubota, A, Imura, H	Biochem Biophys Res Commun	1993
1337145	Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase Ihara, Y, Seino, M, Yamada, Y, Kagimoto, S, Reisine, T, Bell, GI, Seino, S, Law, SF, Seino, Y, Kubota, A	Mol Endocrinol	1992
1346068	Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney Yamada, Y, Post, SR, Bell, GI, Wang, K, Seino, S, Tager, HS	Proc Natl Acad Sci U S A	1992