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SLC18A2 [plasma membrane]
Stable Identifier
R-HSA-374907
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Vesicular monoamine transporter
Locations in the PathwayBrowser for interactor UniProt:Q16617%20NKG7
Expand all
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter release cycle (Homo sapiens)
Dopamine Neurotransmitter Release Cycle (Homo sapiens)
Release of docked dopamine loaded synaptic vesicle (Homo sapiens)
SLC18A2 [plasma membrane] (Homo sapiens)
Norepinephrine Neurotransmitter Release Cycle (Homo sapiens)
Release of noradrenaline at the synapse (Homo sapiens)
SLC18A2 [plasma membrane] (Homo sapiens)
Serotonin Neurotransmitter Release Cycle (Homo sapiens)
Release of docked serotonin loaded synaptic vesicle (Homo sapiens)
SLC18A2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q05940 SLC18A2
Gene Names
SLC18A2, SVMT, VMAT2
Chain
chain:1-514
Reference Genes
BioGPS Gene:6571 SLC18A2
COSMIC (genes):SLC18A2 SLC18A2
CTD Gene:6571 SLC18A2
dbSNP Gene:6571 SLC18A2
ENSEMBL:ENSG00000165646 SLC18A2
ENSEMBL_homo_sapiens_GENE:ENSG00000165646.14 SLC18A2
HGNC:10935 SLC18A2
KEGG Gene (Homo sapiens):6571 SLC18A2
Monarch:6571 SLC18A2
NCBI Gene:6571 SLC18A2
OMIM:193001 SLC18A2
UCSC:Q05940 SLC18A2
Reference Transcript
RefSeq:NM_003054.4 SLC18A2
Other Identifiers
11734588_a_at
11759609_at
1553328_PM_a_at
1553328_a_at
16709713
205857_PM_at
205857_at
3266285
3266288
3266289
3266292
3266294
3266297
3266299
3266301
3266303
3266305
3266311
3266312
3266314
3266317
3266318
3266322
3266323
3266324
3266326
35854_at
53644_at
6571
7930837
A_23_P52499
A_32_P127599
GO:0001975
GO:0002376
GO:0002552
GO:0002553
GO:0005215
GO:0005335
GO:0005515
GO:0005813
GO:0005815
GO:0005856
GO:0005886
GO:0006836
GO:0006954
GO:0007268
GO:0007626
GO:0008021
GO:0008504
GO:0009636
GO:0009791
GO:0015311
GO:0015842
GO:0015844
GO:0015872
GO:0016020
GO:0016192
GO:0022857
GO:0023052
GO:0030424
GO:0030425
GO:0030658
GO:0030667
GO:0030672
GO:0031410
GO:0042137
GO:0042995
GO:0043195
GO:0043226
GO:0043231
GO:0045202
GO:0048856
GO:0051610
GO:0051615
GO:0055085
GO:0070083
GO:0098691
GO:0098700
GO:0099123
GO:1902600
GO:1903427
HMNXSV003054807
Hs.1813.0.S2_3p_at
Hs2.1813.1.S1_3p_s_at
ILMN_2070003
L14269_at
TC10000850.hg
Participates
as an output of
Release of docked dopamine loaded synaptic vesicle (Homo sapiens)
Release of noradrenaline at the synapse (Homo sapiens)
Release of docked serotonin loaded synaptic vesicle (Homo sapiens)
Other forms of this molecule
SLC18A2 [clathrin-sculpted monoamine transport vesicle membrane]
Inferred To
Homologues of SLC18A2 [plasma membrane]
(Drosophila melanogaster)
Vmat [plasma membrane]
(Drosophila melanogaster)
cat-1 [plasma membrane]
(Caenorhabditis elegans)
prt [plasma membrane]
(Drosophila melanogaster)
LOC101732756 [plasma membrane]
(Xenopus tropicalis)
SLC18A2 [plasma membrane]
(Bos taurus)
SLC18A2 [plasma membrane]
(Canis familiaris)
SLC18A2 [plasma membrane]
(Gallus gallus)
SLC18A2 [plasma membrane]
(Sus scrofa)
Slc18a2 [plasma membrane]
(Mus musculus)
Slc18a2 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_003045.2
Guide to Pharmacology - Targets
1012
OpenTargets
ENSG00000165646
ZINC - Substances
VMAT2_HUMAN
ZINC target
Q05940
ZINC - Biogenic
VMAT2_HUMAN
PRO
Q05940
GeneCards
Q05940
HPA
ENSG00000165646-SLC18A2
Ensembl
ENST00000644641
,
ENSP00000496339
,
ENSG00000165646
Pharos - Targets
Q05940
ZINC - Predictions - Purchasable
VMAT2_HUMAN
Orphanet
22175
HMDB Protein
HMDBP02489
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96DZ9-2 CMTM5
0.556
3
UniProt:Q9BVC6 TM109
0.556
3
UniProt:Q96B49 TOMM6
1
TOMM6 [mitochondrial outer membrane]
(R-HSA-1252171)
0.556
3
UniProt:Q6PL45-2 BRICD5
0.556
3
UniProt:Q6N075 MFSD5
0.556
3
UniProt:Q16617 NKG7
0.556
3
UniProt:Q9BXR6 CFHR5
1
CFHR5 [extracellular region]
(R-HSA-8851419)
0.556
3
UniProt:Q8TDV0 GP151
0.556
3
UniProt:P30825 SLC7A1
1
SLC7A1 [plasma membrane]
(R-HSA-375771)
0.556
3
UniProt:P25025 CXCR2
2
CXCR2 [secretory granule membrane]
(R-HSA-6804771)
CXCR2 [plasma membrane]
(R-HSA-373796)
0.556
3
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