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SLC22A2 [plasma membrane]
Stable Identifier
R-HSA-374914
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
OCT2, Organic cation transporter 2, Noradrenaline uptake transporter
Locations in the PathwayBrowser
Expand all
Drug ADME (Homo sapiens)
Abacavir ADME (Homo sapiens)
Abacavir transmembrane transport (Homo sapiens)
abacavir [extracellular] => abacavir [cytosol] (Homo sapiens)
SLC22A1,2,3 [plasma membrane] (Homo sapiens)
SLC22A2 [plasma membrane] (Homo sapiens)
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter clearance (Homo sapiens)
Noradrenaline clearance from the synaptic cleft (Homo sapiens)
SLC22A1,SLC22A2 [plasma membrane] (Homo sapiens)
SLC22A2 [plasma membrane] (Homo sapiens)
Neurotransmitter release cycle (Homo sapiens)
Norepinephrine Neurotransmitter Release Cycle (Homo sapiens)
Uptake of Noradrenaline (Homo sapiens)
SLC22A1,SLC22A2 [plasma membrane] (Homo sapiens)
SLC22A2 [plasma membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
Na+/Cl- dependent neurotransmitter transporters (Homo sapiens)
Uptake of Noradrenaline (Homo sapiens)
SLC22A1,SLC22A2 [plasma membrane] (Homo sapiens)
SLC22A2 [plasma membrane] (Homo sapiens)
Organic cation/anion/zwitterion transport (Homo sapiens)
Organic cation transport (Homo sapiens)
OCT1 transports organic cations into hepatic cells (Homo sapiens)
OCT1 [plasma membrane] (Homo sapiens)
SLC22A2 [plasma membrane] (Homo sapiens)
OCT1 transports organic cations out of hepatic cells (Homo sapiens)
OCT1 [plasma membrane] (Homo sapiens)
SLC22A2 [plasma membrane] (Homo sapiens)
OCT2 mediates tubular secretion of organic cations in the kidney (Homo sapiens)
SLC22A1,SLC22A2 [plasma membrane] (Homo sapiens)
SLC22A2 [plasma membrane] (Homo sapiens)
OCT2 mediates tubular uptake of organic cations in the kidney (Homo sapiens)
SLC22A1,SLC22A2 [plasma membrane] (Homo sapiens)
SLC22A2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15244 SLC22A2
Gene Names
SLC22A2, OCT2
Chain
chain:1-555
Reference Genes
BioGPS Gene:6582 SLC22A2
COSMIC (genes):SLC22A2 SLC22A2
CTD Gene:6582 SLC22A2
dbSNP Gene:6582 SLC22A2
ENSEMBL:ENSG00000112499 SLC22A2
ENSEMBL_homo_sapiens_GENE:ENSG00000112499.13 SLC22A2
HGNC:10966 SLC22A2
KEGG Gene (Homo sapiens):6582 SLC22A2
Monarch:6582 SLC22A2
NCBI Gene:6582 SLC22A2
OMIM:602608 SLC22A2
UCSC:O15244 SLC22A2
Reference Transcript
RefSeq:NM_003058.3 SLC22A2
Other Identifiers
11744845_a_at
11744951_a_at
11752257_a_at
11756364_a_at
17025323
207429_PM_at
207429_at
2982533
2982534
2982535
2982539
2982542
2982543
2982547
2982548
2982552
2982553
2982554
2982555
2982556
2982559
2982560
2982562
2982563
2982564
2982565
2982566
35867_at
6582
8130582
A_23_P111395
GE60209
GO:0003013
GO:0005215
GO:0005275
GO:0005277
GO:0005326
GO:0005576
GO:0005615
GO:0005886
GO:0006811
GO:0006812
GO:0006836
GO:0006837
GO:0006919
GO:0007589
GO:0008504
GO:0008514
GO:0009925
GO:0010628
GO:0015101
GO:0015132
GO:0015179
GO:0015214
GO:0015220
GO:0015234
GO:0015489
GO:0015562
GO:0015606
GO:0015651
GO:0015695
GO:0015732
GO:0015837
GO:0015847
GO:0015848
GO:0015870
GO:0015871
GO:0015872
GO:0015874
GO:0016020
GO:0016323
GO:0016324
GO:0019534
GO:0022857
GO:0042908
GO:0042910
GO:0043226
GO:0048241
GO:0051608
GO:0051610
GO:0051615
GO:0051620
GO:0055085
GO:0061459
GO:0070062
GO:0071934
GO:0072530
GO:0089718
GO:0090494
GO:0097638
GO:0098793
GO:0140115
GO:0150104
GO:1901998
GO:1902475
GO:1903711
GO:1903826
GO:1990962
HMNXSV003004150
ILMN_1762410
ILMN_2334193
PH_hs_0020525
TC06002279.hg
g4507000_3p_at
Participates
as a member of
SLC22A1,2,3 [plasma membrane] (Homo sapiens)
SLC22A1,SLC22A2 [plasma membrane] (Homo sapiens)
as a candidate of
OCT1 [plasma membrane] (Homo sapiens)
Inferred To
Orct [plasma membrane]
(Drosophila melanogaster)
Dmel\CG16727 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG14855 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG4630 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG7342 [plasma membrane]
(Drosophila melanogaster)
pes-23 [plasma membrane]
(Caenorhabditis elegans)
Dmel\CG10486 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG6356 [plasma membrane]
(Drosophila melanogaster)
slc22a2 [plasma membrane]
(Xenopus tropicalis)
Dmel\CG5592 [plasma membrane]
(Drosophila melanogaster)
CG6596 [plasma membrane]
(Drosophila melanogaster)
CT19169 [plasma membrane]
(Drosophila melanogaster)
zgc:64076 [plasma membrane]
(Danio rerio)
CarT [plasma membrane]
(Drosophila melanogaster)
Homologues of SLC22A2 [plasma membrane]
(Caenorhabditis elegans)
Homologues of SLC22A2 [plasma membrane]
(Drosophila melanogaster)
oct-2 [plasma membrane]
(Caenorhabditis elegans)
suex-2 [plasma membrane]
(Caenorhabditis elegans)
CG31530-RA [plasma membrane]
(Drosophila melanogaster)
CG8654-RA [plasma membrane]
(Drosophila melanogaster)
Dmel\CG17752 [plasma membrane]
(Drosophila melanogaster)
SLC22A2 [plasma membrane]
(Bos taurus)
SLC22A2 [plasma membrane]
(Caenorhabditis elegans)
SLC22A2 [plasma membrane]
(Canis familiaris)
SLC22A2 [plasma membrane]
(Gallus gallus)
SLC22A2 [plasma membrane]
(Sus scrofa)
Slc22a2 [plasma membrane]
(Mus musculus)
Slc22a2 [plasma membrane]
(Rattus norvegicus)
Dmel\CG7333 [plasma membrane]
(Drosophila melanogaster)
Orct2 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG4465 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG14857 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG4462 [plasma membrane]
(Drosophila melanogaster)
oct-1 [plasma membrane]
(Caenorhabditis elegans)
Dmel\CG7084 [plasma membrane]
(Drosophila melanogaster)
Balat [plasma membrane]
(Drosophila melanogaster)
Dmel\CG14856 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG6231 [plasma membrane]
(Drosophila melanogaster)
SLC22A [plasma membrane]
(Drosophila melanogaster)
Dmel\CG17751 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG7458 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG4459 [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_003049.2
ZINC - World Drugs
S22A2_HUMAN
Guide to Pharmacology - Targets
1020
OpenTargets
ENSG00000112499
ZINC - FDA approved
S22A2_HUMAN
ZINC - Substances
S22A2_HUMAN
ZINC - Biogenic
S22A2_HUMAN
ZINC target
O15244
PRO
O15244
ZINC - Investigational
S22A2_HUMAN
ZINC - Metabolites
S22A2_HUMAN
GeneCards
O15244
HPA
ENSG00000112499-SLC22A2
Ensembl
ENSG00000112499
,
ENSP00000355920
,
ENST00000366953
Pharos - Targets
O15244
Orphanet
24908
ZINC - Predictions - Purchasable
S22A2_HUMAN
HMDB Protein
HMDBP04308
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